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The characterization of individual nanoparticles in a liquid constitutes a critical challenge for environmental, material, and biological sciences. To detect nanoparticles, electronic approaches are especially desirable owing to their…

Nanopore-based sensing platforms have transformed single-molecule detection and analysis. The foundation of nanopore translocation experiments lies in conductance measurements, yet existing models, which are largely phenomenological, are…

生物物理 · 物理学 2023-12-19 Arjav Shah , Shakul Pathak , Slaven Garaj , Martin Z. Bazant , Ankur Gupta , Patrick S. Doyle

The resistive-pulse technique provides a fast and label-free method for nanoparticle detection. In order to achieve a higher sensitivity, thin nanopores, such as silicon nitride pores, are usually considered. In this paper, nanoparticle…

化学物理 · 物理学 2018-09-25 Yinghua Qiu

With the resistive-pulse technique (RPT), nanopores serve as the nanofluidic sensors of various analytes for their many physical and chemical properties. Here, we focus on the size measurement and its theoretical prediction for sub-200 nm…

化学物理 · 物理学 2024-03-08 Zihao Gao , Long Ma , Zhe Liu , Jun Huang , Hanlian Liu , Chuanzhen Huang , Yinghua Qiu

Nanopore sensing is a key technology for single-molecule detection and analysis. Solid-state nanopores have emerged as a versatile platform, since their fabrication allows to engineer their properties by controlling size, shape, and…

Resistive Pulse Sensing (RPS) is a key label-free technology to measure particles and single-cell size distribution. As a growing corpus of evidence supports that cancer cells exhibit distinct mechanical phenotypes from healthy cells,…

生物物理 · 物理学 2020-04-01 Antoine Riaud , Anh L. P. Thai , Wei Wang , Valerie Taly

Tunable nanopores in elastomeric membranes have been used to study the dependence of ionic current blockade rate on the concentration and electrophoretic mobility of particles in aqueous suspensions. A range of nanoparticle sizes, materials…

软凝聚态物质 · 物理学 2010-05-25 G R Willmott , R Vogel , S S C Yu , L G Groenewegen , G S Roberts , D Kozak , W Anderson , M Trau

Resizable elastomeric nanopores have been used to measure pulses of ionic current caused by carboxylated polystyrene spheres of diameter 200 nm and 800 nm. The nanopores represent a novel technology which enables nanoscale resizing of a…

介观与纳米尺度物理 · 物理学 2010-02-04 Geoff R. Willmott , Lara H. Bauerfeind

Nanopore resistive pulse techniques are based on analysis of current or voltage spikes in the recorded signal. These spikes result from translocation of nanometer sized analytes through a nanopore. The most important information that needs…

数据分析、统计与概率 · 物理学 2015-03-13 Nima Arjmandi , Willem Van Roy , Liesbet Lagae , Gustaaf Borghs

Solid-state nanopore and nanopipette sensors are powerful devices for the detection, quantification and structural analysis of biopolymers such as DNA and proteins, especially in carrier-enhanced resistive-pulse sensing. However, hundreds…

介观与纳米尺度物理 · 物理学 2025-10-14 Cengiz J. Khan , Oliver J. Irving , Rand A. Al-Waqfi , Giorgio Ferrari , Tim Albrecht

Throughout our history, we, humans, have sought to better control and understand our environment. To this end, we have extended our natural senses with a host of sensors-tools that enable us to detect both the very large, such as the…

生物物理 · 物理学 2023-06-09 Kherim Willems

Adsorption processes play a fundamental role in molecular transport through nanofluidic systems, but their signatures in measured signals are often hard to distinguish from other processes like diffusion. In this paper, we derive an…

软凝聚态物质 · 物理学 2025-11-07 Anna Drummond Young , Alice L. Thorneywork , Sophie Marbach

A microscopic physical analysis of the various resistive effects involved in the electronic detection of single biomolecules in a nanopore of a MoS2 nanoribbon is presented. The analysis relies on a combined experimental-theoretical…

介观与纳米尺度物理 · 物理学 2020-04-23 Mingye Xiong , Michael Graf , Nagendra Athreya , Aleksandra Radenovic , Jean-Pierre Leburton

Diffusion pore imaging is an extension of diffusion-weighted nuclear magnetic resonance imaging enabling the direct measurement of the shape of arbitrarily formed, closed pores by probing diffusion restrictions using the motion of…

Being motivated by recent progress in nanopore sensing, we develop a theory of the effect of large analytes, or blockers, trapped within the nanopore confines, on diffusion flow of small solutes. The focus is on the nanopore diffusion…

定量方法 · 定量生物学 2022-07-20 Leonardo Dagdug , Alexei T. Skvortsov , Alexander M. Berezhkovskii , Sergey M. Bezrukov

Networks of nanowires and nanosheets are important for many applications in printed electronics. However, the network conductivity and mobility are usually limited by the inter-particle junction resistance, a property that is challenging to…

Solid-state nanopores offer a powerful platform for nanoscale analysis of individual analytes, including biomolecules and functionalized nanoparticles, by confining them within a precisely defined sensing region. However, their inherently…

Biosensing with ferromagnet-based magnetoresistive devices has been dominated by electrical detection of particle-induced changes to the devices' static magnetic configuration. There are however potential advantages to be gained from using…

Significant progress has been made for assessing the influence of porosity on the performance metrics for cast components through various modeling techniques. However, a computationally efficient framework to account for porosity with…

计算工程、金融与科学 · 计算机科学 2022-04-05 Shiguang Deng , Carl Soderhjelm , Diran Apelian , Krishnan Suresh

We describe two different modes for electronically detecting an adsorbed molecule using a nanoscale transistor. The attachment of an ionic molecular target shifts the threshold voltage through modulation of the depletion layer…

介观与纳米尺度物理 · 物理学 2008-08-19 S. Vasudevan , K. Walczak , N. Kapur , M. Neurock , A. W. Ghosh
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