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Creating high quality treatment plans is crucial for a successful radiotherapy treatment. However, it demands substantial effort and special training for dosimetrists. Existing automated treatment planning systems typically require either…

Modern external beam cancer radiotherapy applies prescribed radiation doses to tumor targets while minimally affecting nearby vulnerable organs-at-risk (OARs). Creating a treatment plan is difficult and time-consuming with no guarantee of…

医学物理 · 物理学 2021-07-07 Lyndon Hibbard

Electric vertical-takeoff and landing (eVTOL) aircraft, recognized for their maneuverability and flexibility, offer a promising alternative to our transportation system. However, the operational effectiveness of these aircraft faces many…

机器人学 · 计算机科学 2024-03-25 Songyang Liu , Shuai Li , Haochen Li , Weizi Li , Jindong Tan

Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. There has been a sharp uptake of proton beam therapy in recent years as improved delivery techniques and patient…

The study of protection techniques, such as pre-provisioning (off-line) and provisioning (on-line), has been explored in several ways in the optical network literature. In the new Elastic Optical Network (EON) paradigm, the pre-provisioning…

网络与互联网体系结构 · 计算机科学 2022-02-08 Paulo José S. Júnior , Lucas R. Costa , André C. Drummond

We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy. Our theoretical model consists of a system of Markov chains…

医学物理 · 物理学 2019-05-01 Ramin Abolfath , Yusuf Helo , Lawrence Bronk , Alejandro Carabe , David Grosshans , Radhe Mohan

Strong multiple scattering of the probe in scanning transmission electron microscopy (STEM) means image simulations are usually required for quantitative interpretation and analysis of elemental maps produced by electron energy-loss…

材料科学 · 物理学 2019-12-25 Hamish G. Brown , Jim Ciston , Colin Ophus

FLASH is a new treatment modality that requires optimization of dose, dose rate, and LET. Here we validate these three quantities under FLASH conditions, which includes the quantum uncertainty in the time-dependent instantaneous dose rate…

Large-scale generative models like DeepSeek-R1 and OpenAI-O1 benefit substantially from chain-of-thought (CoT) reasoning, yet pushing their performance typically requires vast data, large model sizes, and full-parameter fine-tuning. While…

机器学习 · 计算机科学 2025-09-17 Yining Huang , Bin Li , Keke Tang , Meilian Chen

In the last few decades, several novel algorithms have been designed for finding critical points on PES and the minimum energy paths connecting them. This has led to considerably improve our understanding of reaction mechanisms and kinetics…

计算工程、金融与科学 · 计算机科学 2024-10-30 Sandra Liz Simon , Nitin Kaistha , Vishal Agarwal

We present a new and more efficient technique for computing the route that maximizes the probability of on-time arrival in stochastic networks, also known as the path-based stochastic on-time arrival (SOTA) problem. Our primary contribution…

数据结构与算法 · 计算机科学 2016-10-07 Mehrdad Niknami , Samitha Samaranayake

Evolution Strategy (ES) algorithms have shown promising results in training complex robotic control policies due to their massive parallelism capability, simple implementation, effective parameter-space exploration, and fast training time.…

机器人学 · 计算机科学 2022-07-28 Kuang-Huei Lee , Ofir Nachum , Tingnan Zhang , Sergio Guadarrama , Jie Tan , Wenhao Yu

In vitro fertilization-embryo transfer (IVF-ET) stands as one of the most prevalent treatments for infertility. During an IVF-ET cycle, the time interval between trigger shot and oocyte pickup (OPU) is a pivotal period for follicular…

Many evolutionary algorithms (EAs) take advantage of parallel evaluation of candidates. However, if evaluation times vary significantly, many worker nodes (i.e.,\ compute clients) are idle much of the time, waiting for the next generation…

神经与进化计算 · 计算机科学 2024-01-02 Jason Liang , Hormoz Shahrzad , Risto Miikkulainen

This paper presents a comparative study of the applicability and accuracy of optimal control methods and neural network-based estimators in the context of porkchop plots for preliminary asteroid rendezvous mission design. The scenario…

最优化与控制 · 数学 2026-02-19 Zhong Zhang , Niccolò Michelotti , Gonçalo Oliveira Pinho , Yilin Zou , Francesco Topputo

Radiation therapy treatment planning can be viewed as an iterative hyperparameter tuning process to balance conflicting clinical goals. In this work, we investigated the performance of modern Bayesian Optimization (BO) methods on automated…

医学物理 · 物理学 2023-02-15 Qingying Wang , Ruoxi Wang , Jiacheng Liu , Fan Jiang , Haizhen Yue , Yi Du , Hao Wu

To improve the quality of cancer treatment with protons, a translation of X-ray Computed Tomography (CT) images into a map of the proton stopping powers needs to be more accurate. Proton stopping powers determined from CT images have…

In radiation therapy, mathematical methods have been used for optimizing treatment planning for delivery of sufficient dose to the cancerous cells while keeping the dose to critical surrounding structures minimal. This optimization problem…

医学物理 · 物理学 2015-06-16 Hamed Yarmand , David Craft

SPECT (Single-photon Emission Computerized Tomography) and PET (Positron Emission Tomography) are essential medical imaging tools, for which the sampling angle number, scan time should be chosen carefully to compromise between image quality…

医学物理 · 物理学 2015-06-16 Xiaolin Zhou , Minkai Yun , Xuexiang Cao , Shuangquan Liu , Lu Wang , Xianchao Huang , Long Wei

The need of real-time of monitoring and alerting systems for Space Weather hazards has grown significantly in the last two decades. One of the most important challenge for space mission operations and planning is the prediction of solar…

太阳与恒星天体物理 · 物理学 2024-06-19 Mirko Stumpo , Monica Laurenza , Simone Benella , Maria Federica Marcucci