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Synthetic DNA approaches 227.5 exabytes per gram of storage density with stability over millennial timescales. Realising this capacity requires error-correction codes that recover data from substantial synthesis and sequencing errors.…

信息论 · 计算机科学 2026-04-23 James L. Banal

The synthesis of DNA strands remains the most costly part of the DNA storage system. Thus, to make DNA storage system more practical, the time and materials used in the synthesis process have to be optimized. We consider the most common…

信息论 · 计算机科学 2023-05-15 Johan Chrisnata , Han Mao Kiah , Van Long Phuoc Pham

Discovering fine-grained categories from coarsely labeled data is a practical and challenging task, which can bridge the gap between the demand for fine-grained analysis and the high annotation cost. Previous works mainly focus on…

机器学习 · 计算机科学 2023-10-17 Wenbin An , Feng Tian , Wenkai Shi , Yan Chen , Qinghua Zheng , QianYing Wang , Ping Chen

Digital information can be encoded in the building-block sequence of macromolecules, such as RNA and single-stranded DNA. Methods of "writing" and "reading" macromolecular strands are currently available, but they are slow and expensive. In…

新兴技术 · 计算机科学 2017-09-14 Pramod K. Khulbe , Raphael Gruener , Masud Mansuripur

DNA is emerging as an increasingly attractive medium for data storage due to a number of important and unique advantages it offers, most notably the unprecedented durability and density. While the technology is evolving rapidly, the…

新兴技术 · 计算机科学 2022-05-03 Dehui Lin , Yasamin Tabatabaee , Yash Pote , Djordje Jevdjic

DNA storage technology offers new possibilities for addressing massive data storage due to its high storage density, long-term preservation, low maintenance cost, and compact size. To improve the reliability of stored information, base…

机器学习 · 计算机科学 2024-09-24 Bowen Liu , Jiankun Li

Radar signals have been dramatically increasing in complexity, limiting the source separation ability of traditional approaches. In this paper we propose a Deep Learning-based clustering method, which encodes concurrent signals into images,…

计算机视觉与模式识别 · 计算机科学 2023-08-22 Stefano Gasperini , Magdalini Paschali , Carsten Hopke , David Wittmann , Nassir Navab

The DNA storage channel is considered, in which a codeword is comprised of $M$ unordered DNA molecules. At reading time, $N$ molecules are sampled with replacement, and then each molecule is sequenced. A coded-index concatenated-coding…

信息论 · 计算机科学 2022-05-23 Nir Weinberger

Nanopore sequencing can read substantially longer sequences of nucleic acid molecules, called reads, than other sequencing methods, which has led to advances in genomic analysis such as the gapless human genome assembly. By analyzing the…

基因组学 · 定量生物学 2026-05-21 Simon Ambrozak , Ulysse McConnell , Bhargav Srinivasan , Burak Ozkan , Ernest Zhang , Can Firtina

The ability to quickly and accurately identify microbial species in a sample, known as metagenomic profiling, is critical across various fields, from healthcare to environmental science. This paper introduces a novel method to profile…

基因组学 · 定量生物学 2025-04-10 Riselda Kodra , Hadjer Benmeziane , Irem Boybat , William Andrew Simon

DNA, with remarkable properties of high density, durability, and replicability, is one of the most appealing storage media. Emerging DNA storage technologies use composite DNA letters, where information is represented by probability…

信息论 · 计算机科学 2025-03-26 Wenkai Zhang , Zhiying Wang

This paper introduces a new solution to DNA storage that integrates all three steps of retrieval, namely clustering, reconstruction, and error correction. DNA-correcting codes are presented as a unique solution to the problem of ensuring…

信息论 · 计算机科学 2024-07-02 Avital Boruchovsky , Daniella Bar-Lev , Eitan Yaakobi

A promising direction in deep learning research consists in learning representations and simultaneously discovering cluster structure in unlabeled data by optimizing a discriminative loss function. As opposed to supervised deep learning,…

Solid-state nanopore and nanopipette sensors are powerful devices for the detection, quantification and structural analysis of biopolymers such as DNA and proteins, especially in carrier-enhanced resistive-pulse sensing. However, hundreds…

介观与纳米尺度物理 · 物理学 2025-10-14 Cengiz J. Khan , Oliver J. Irving , Rand A. Al-Waqfi , Giorgio Ferrari , Tim Albrecht

We introduce DNABERT-S, a tailored genome model that develops species-aware embeddings to naturally cluster and segregate DNA sequences of different species in the embedding space. Differentiating species from genomic sequences (i.e., DNA…

基因组学 · 定量生物学 2024-10-23 Zhihan Zhou , Weimin Wu , Harrison Ho , Jiayi Wang , Lizhen Shi , Ramana V Davuluri , Zhong Wang , Han Liu

The errors occurring in DNA-based storage are correlated in nature, which is a direct consequence of the synthesis and sequencing processes. In this paper, we consider the memory-$k$ nanopore channel model recently introduced by Hamoum et…

信息论 · 计算机科学 2023-03-27 Issam Maarouf , Eirik Rosnes , Alexandre Graell i Amat

DNA sequence encoding is fundamental to gene function prediction, protein synthesis, and diverse downstream biological tasks. Despite the substantial progress achieved by large-scale DNA sequence pretraining, existing studies have…

机器学习 · 计算机科学 2026-04-21 Zhijiang Tang , Jiaxin Qi , Yan Cui , Jinli Ou , Yuhua Zheng , Jianqiang Huang

In this paper, we consider a concatenated coding based class of DNA storage codes in which the selected molecules are constrained to be taken from an ``inner'' codebook associated with the sequencing channel. This codebook is used in a…

信息论 · 计算机科学 2025-06-19 Yan Hao Ling , Jonathan Scarlett

In the wake of the swift evolution of technologies such as the Internet of Things (IoT), the global data landscape undergoes an exponential surge, propelling DNA storage into the spotlight as a prospective medium for contemporary cloud…

机器学习 · 计算机科学 2024-09-20 Wenfeng Wu , Luping Xiang , Qiang Liu , Kun Yang

In the recent years, DNA has emerged as a potentially viable storage technology. DNA synthesis, which refers to the task of writing the data into DNA, is perhaps the most costly part of existing storage systems. Accordingly, this high cost…

信息论 · 计算机科学 2022-04-15 Ohad Elishco , Wasim Huleihel