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Several technological limitations of traditional silicon based computing are leading towards the paradigm shift, from silicon to carbon, in computational world. Among the unconventional modes of computing evolved in past several decades,…

生物大分子 · 定量生物学 2020-10-02 Mandrita Mondal , Kumar S. Ray

In this paper, we study achievable rates of concatenated coding schemes over a deoxyribonucleic acid (DNA) storage channel. Our channel model incorporates the main features of DNA-based data storage. First, information is stored on many,…

信息论 · 计算机科学 2020-05-04 Andreas Lenz , Lorenz Welter , Sven Puchinger

The short lifespan of traditional data storage media, coupled with an exponential increase in storage demand, has made long-term archival a fundamental problem in the data storage industry and beyond. Consequently, researchers are looking…

图像与视频处理 · 电气工程与系统科学 2026-03-06 Xavier Pic , Nimesh Pinnamaneni , Raja Appuswamy

Due to their sequential nature, traditional DNA synthesis methods are expensive in terms of time and resources. They also fabricate multiple copies of the same strand, introducing redundancy. This redundancy can be leveraged to enhance the…

信息论 · 计算机科学 2025-10-29 Frederik Walter , Yonatan Yehezkeally

Due to the redundant nature of DNA synthesis and sequencing technologies, a basic model for a DNA storage system is a multi-draw "shuffling-sampling" channel. In this model, a random number of noisy copies of each sequence is observed at…

信息论 · 计算机科学 2021-12-06 Kel Levick , Reinhard Heckel , Ilan Shomorony

The yearly global production of data is growing exponentially, outpacing the capacity of existing storage media, such as tape and disk, and surpassing our ability to store it. DNA storage - the representation of arbitrary information as…

定量方法 · 定量生物学 2023-10-04 Thomas Heinis , Roman Sokolovskii , Jamie J. Alnasir

We address the problem of acoustic source separation in a deep learning framework we call "deep clustering." Rather than directly estimating signals or masking functions, we train a deep network to produce spectrogram embeddings that are…

神经与进化计算 · 计算机科学 2015-08-19 John R. Hershey , Zhuo Chen , Jonathan Le Roux , Shinji Watanabe

Digital information can be encoded in the building-block sequence of macro-molecules, such as RNA and single-stranded DNA. Methods of "writing" and "reading" macromolecular strands are currently available, but they are slow and expensive.…

新兴技术 · 计算机科学 2017-09-14 Masud Mansuripur , Pramod Khulbe

Composite DNA is a recent method to increase the base alphabet size in DNA-based data storage.This paper models synthesizing and sequencing of composite DNA and introduces coding techniques to correct substitutions, losses of entire…

信息论 · 计算机科学 2025-10-29 Frederik Walter , Omer Sabary , Antonia Wachter-Zeh , Eitan Yaakobi

DNA Data storage has recently attracted much attention due to its durable preservation and extremely high information density (bits per gram) properties. In this work, we propose a hybrid coding strategy comprising of generalized…

信息论 · 计算机科学 2021-12-20 Yixin Wang , Li Deng , Md. Noor-A-Rahim , Erry Gunawan , Yong L. Guan , Zhi P. Shi , Chueh L. Poh

DNA is an attractive medium for digital data storage. When data is stored on DNA, errors occur, which makes error-correcting coding techniques critical for reliable DNA data storage. To reduce the errors, a common technique is to include…

信息论 · 计算机科学 2024-06-27 Franziska Weindel , Andreas L. Gimpel , Robert N. Grass , Reinhard Heckel

We consider the problem of assembling a sequence based on a collection of its substrings observed through a noisy channel. The mathematical basis of the problem is the construction and design of sequences that may be discriminated based on…

信息论 · 计算机科学 2015-11-04 Han Mao Kiah , Gregory J. Puleo , Olgica Milenkovic

Deep clustering is a deep neural network-based speech separation algorithm that first trains the mixed component of signals with high-dimensional embeddings, and then uses a clustering algorithm to separate each mixture of sources. In this…

音频与语音处理 · 电气工程与系统科学 2019-01-16 Soyeon Choe , Soo-Whan Chung , Youna Ji , Hong-Goo Kang

DNA is an attractive candidate for data storage. Its millennial durability and nanometer scale offer exceptional data density and longevity. Its relevance to medical applications also drives advances in DNA-related biotechnology. To protect…

信息论 · 计算机科学 2025-11-25 Yu-Ting Lin , Hsin-Po Wang , Venkatesan Guruswami

Nanopore sequencing is an emerging DNA sequencing technology that has been proposed for use in DNA storage systems. We propose the noisy nanopore channel model for nanopore sequencing. This model captures duplications, inter-symbol…

信息论 · 计算机科学 2022-05-10 Brendon McBain , Emanuele Viterbo , James Saunderson

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

定量方法 · 定量生物学 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi

In this paper, we consider the outer channel for DNA-based data storage. When transmitting over the outer channel, each DNA string is treated as a unit/symbol that would be either correctly received, or erased, or corrupted by uniformly…

信息论 · 计算机科学 2025-09-23 Xuan He , Yi Ding , Kui Cai , Guanghui Song , Bin Dai , Xiaohu Tang

Clustering is widely used in unsupervised learning method that deals with unlabeled data. Deep clustering has become a popular study area that relates clustering with Deep Neural Network (DNN) architecture. Deep clustering method…

机器学习 · 计算机科学 2020-07-14 Abu Quwsar Ohi , M. F. Mridha , Farisa Benta Safir , Md. Abdul Hamid , Muhammad Mostafa Monowar

Purpose Nanopore-based molecular sensing and measurement, specifically Deoxyribonucleic acid (DNA) sequencing, is advancing at a fast pace. Some embodiments have matured from coarse particle counters to enabling full human genome assembly.…

仪器与探测器 · 物理学 2021-10-06 Mehdi Habibi , Yunus Dawji , Ebrahim Ghafar-Zadeh , Sebastian Magierowski

Nanopore based sequencing has demonstrated significant potential for the development of fast, accurate, and cost-efficient fingerprinting techniques for next generation molecular detection and sequencing. We propose a specific multi-layered…

介观与纳米尺度物理 · 物理学 2014-05-15 Towfiq Ahmed , Jason T. Haraldsen , John J. Rehr , Massimiliano Di Ventra , Ivan K. Schuller , Alexander V. Balatsky