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Axonal connections in the mouse brain show exponential scaling in the number of connections with their length, recently referred to as the exponential distance rule (EDR). This work investigates the theoretical and experimental background…

生物物理 · 物理学 2024-02-23 Máté Józsa , Zsolt I. Lázár , Mária Ercsey-Ravasz

The recent reconstruction of the Drosophila brain provides a neural network of unprecedented size and level of details. In this work, we study the geometrical properties of this system by applying network embedding techniques to the graph…

物理与社会 · 物理学 2026-02-19 Bendegúz Sulyok , Sámuel G. Balogh , Gergely Palla

How intelligence emerges from living beings has been a fundamental question in neuroscience. However, it remains largely unanswered due to the complex neuronal dynamics and intricate connections between neurons in real neural systems. To…

神经元与认知 · 定量生物学 2024-09-04 Xiaoyu Zhang , Pengcheng Yang , Jiawei Feng , Qiang Luo , Wei Lin , Xin Lu

Decoding the heterogeneity of biological neural systems is key to understanding the nervous system's complex dynamical behaviors. This study analyzes the comprehensive Drosophila brain connectome, which is the most recent data set,…

神经元与认知 · 定量生物学 2025-10-01 Xiaoyu Zhang , Pengcheng Yang , Yifei Zhang , Bowei Qin , Qiang Luo , Wei Lin , Xin Lu

Brain networks exhibit remarkable structural properties, including high local clustering, short path lengths, and heavy-tailed weight and degree distributions. While these features are thought to enable efficient information processing with…

生物物理 · 物理学 2026-01-09 Aitor Morales-Gregorio , Anno C. Kurth , Karolína Korvasová

The distribution of the geometric distances of connected neurons is a practical factor underlying neural networks in the brain. It can affect the brain\'s dynamic properties at the ground level. Karbowski derived a power-law decay…

神经元与认知 · 定量生物学 2017-02-14 Zhi-Song lv , Chen-Ping Zhu , Pei Nie , Jing Zhao , Hui-Jie Yang , Yan-Jun Wang , Chin-Kun Hu

The first step to understanding brain function is to determine the brain's network structure. We report a three-dimensional analysis of the brain network of the fruit fly Drosophila melanogaster by synchrotron-radiation tomographic…

神经元与认知 · 定量生物学 2016-09-09 Ryuta Mizutani , Rino Saiga , Akihisa Takeuchi , Kentaro Uesugi , Yoshio Suzuki

Network science has been extensively developed to characterize structural properties of complex systems, including brain networks inferred from neuroimaging data. As a result of the inference process, networks estimated from experimentally…

神经元与认知 · 定量生物学 2017-03-10 Catalina Obando , Fabrizio De Vico Fallani

The classification of different patterns of network evolution, for example in brain connectomes or social networks, is a key problem in network inference and modern data science. Building on the notion of a network's Euclidean mirror, which…

统计方法学 · 统计学 2026-01-21 Runbing Zheng , Avanti Athreya , Marta Zlatic , Michael Clayton , Carey E. Priebe

The structural human connectome (i.e.\ the network of fiber connections in the brain) can be analyzed at ever finer spatial resolution thanks to advances in neuroimaging. Here we analyze several large data sets for the human brain network…

神经元与认知 · 定量生物学 2016-06-08 Michael T. Gastner , Géza Ódor

Connectome-constrained neural networks are often evaluated against sparse random controls and then interpreted as evidence that biological graph topology improves learning efficiency. We revisit that claim in a controlled flyvis-based study…

神经元与认知 · 定量生物学 2026-04-07 Nalin Dhiman

Exponential-family random network (ERN) models specify a joint representation of both the dyads of a network and nodal characteristics. This class of models allow the nodal characteristics to be modelled as stochastic processes, expanding…

统计方法学 · 统计学 2013-03-07 Ian E. Fellows , Mark S. Handcock

Brain research has been driven by enquiry for principles of brain structure organization and its control mechanisms. The neuronal wiring map of C. elegans, the only complete connectome available till date, presents an incredible opportunity…

神经元与认知 · 定量生物学 2016-11-28 Rahul Badhwar , Ganesh Bagler

This paper introduces the Neural Differential Manifold (NDM), a novel neural network architecture that explicitly incorporates geometric structure into its fundamental design. Departing from conventional Euclidean parameter spaces, the NDM…

机器学习 · 计算机科学 2025-10-30 Di Zhang

Neural circuit reconstruction at single synapse resolution is increasingly recognized as crucially important to decipher the function of biological nervous systems. Volume electron microscopy in serial transmission or scanning mode has been…

计算机视觉与模式识别 · 计算机科学 2018-05-09 Larissa Heinrich , Jan Funke , Constantin Pape , Juan Nunez-Iglesias , Stephan Saalfeld

Cerebellar-like networks, in which input activity patterns are separated by projection to a much higher-dimensional space before classification, are a recurring neurobiological motif, present in the cerebellum, dentate gyrus, insect…

神经元与认知 · 定量生物学 2026-03-23 William Dorrell , Peter E. Latham

Dimensionality reduction (DR) plays a vital role in the visual analysis of high-dimensional data. One main aim of DR is to reveal hidden patterns that lie on intrinsic low-dimensional manifolds. However, DR often overlooks important…

机器学习 · 计算机科学 2023-02-28 Takanori Fujiwara , Yun-Hsin Kuo , Anders Ynnerman , Kwan-Liu Ma

The dynamical evolution of complex networks underpins the structure-function relationships in natural and artificial systems. Yet, restoring a network's formation from a single static snapshot remains challenging. Here, we present a…

物理与社会 · 物理学 2025-12-10 Jiu Zhang , Zhanwei Du , Hongwei Hu , Ke Wu , Tongchao Li , Chuan Shi , Xiaohui Huang , Yamir Moreno , Yanqing Hu

Many biological systems approach physical limits to their performance, motivating the idea that their behavior and underlying mechanisms could be determined by such optimality. Nevertheless, optimization as a predictive principle has only…

生物物理 · 物理学 2023-12-05 Thomas R Sokolowski , Thomas Gregor , William Bialek , Gašper Tkačik

In this article, we propose a growing network model based on an optimal policy involving both topological and geographical measures. In this model, at each time step, a new node, having randomly assigned coordinates in a $1 \times 1$…

物理与社会 · 物理学 2007-05-23 Yan-Bo Xie , Tao Zhou , Wen-Jie Bai , Guanrong Chen , Wei-Ke Xiao , Bing-Hong Wang
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