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Diffusion-weighted magnetic resonance imaging (DW-MRI) is a critical imaging method for capturing and modeling tissue microarchitecture at a millimeter scale. A common practice to model the measured DW-MRI signal is via fiber orientation…

Traumatic brain injury (TBI) disrupts thalamocortical connectivity, contributing to cognitive impairment and post-traumatic epilepsy (PTE). This study presents a novel tractography-based framework that leverages diffusion maps to capture…

定量方法 · 定量生物学 2025-10-21 Akul Sharma , Anand A. Joshi , Richard M. Leahy

Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter, we designed an optimal diffusion-relaxometry MRI protocol…

Diffusion Weighted Imaging (DWI) is an advanced imaging technique commonly used in neuroscience and neurological clinical research through a Diffusion Tensor Imaging (DTI) model. Volumetric scalar metrics including fractional anisotropy,…

图像与视频处理 · 电气工程与系统科学 2022-11-01 Zihao Tang , Xinyi Wang , Lihaowen Zhu , Mariano Cabezas , Dongnan Liu , Michael Barnett , Weidong Cai , Chengyu Wang

Axonal damage is the primary pathological correlate of long-term impairment in multiple sclerosis (MS). Previous work has demonstrated a strong, quantitative relationship between decrease in axial diffusivity and axonal damage. In the…

计算工程、金融与科学 · 计算机科学 2024-10-15 Nand Sharma

Diffusion magnetic resonance imaging is an imaging technology designed to probe anatomical architectures of biological samples in an in vivo and non-invasive manner through measuring water diffusion. The contribution of this paper is…

Diffusion magnetic resonance imaging, a non-invasive tool to infer white matter fiber connections, produces a large number of streamlines containing a wealth of information on structural connectivity. The size of these tractography outputs…

计算机视觉与模式识别 · 计算机科学 2018-04-17 Kuldeep Kumar , Kaleem Siddiqi , Christian Desrosiers

Diffusion MRI tractography is an advanced imaging technique for quantitative mapping of the brain's structural connectivity. Whole brain tractography (WBT) data contains over hundreds of thousands of individual fiber streamlines (estimated…

图像与视频处理 · 电气工程与系统科学 2022-07-12 Fan Zhang , Tengfei Xue , Weidong Cai , Yogesh Rathi , Carl-Fredrik Westin , Lauren J O'Donnell

Biophysical modeling of diffusion MRI (dMRI) offers the exciting potential of bridging the gap between the macroscopic MRI resolution and microscopic cellular features, effectively turning the MRI scanner into a noninvasive in vivo…

Diffusion tensor imaging (DTI) provides crucial insights into the microstructure of the human brain, but it can be time-consuming to acquire compared to more readily available T1-weighted (T1w) magnetic resonance imaging (MRI). To address…

计算机视觉与模式识别 · 计算机科学 2025-04-22 Shaorong Zhang , Tamoghna Chattopadhyay , Sophia I. Thomopoulos , Jose-Luis Ambite , Paul M. Thompson , Greg Ver Steeg

Diffusion Tensor Imaging (DTI) allows estimating the position, orientation and dimension of bundles of nerve pathways. This non-invasive imaging technique takes advantage of the diffusion of water molecules and determines the diffusion…

计算机视觉与模式识别 · 计算机科学 2011-03-09 Miriam H. A. Bauer , Jan Egger , Daniela Kuhnt , Sebastiano Barbieri , Jan Klein , Horst K. Hahn , Bernd Freisleben , Christopher Nimsky

Diffusion Tensor Imaging (DTI) is an effective tool for the analysis of structural brain connectivity in normal development and in a broad range of brain disorders. However efforts to derive inherent characteristics of structural brain…

计算工程、金融与科学 · 计算机科学 2018-02-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

We present a rotation-equivariant unsupervised learning framework for the sparse deconvolution of non-negative scalar fields defined on the unit sphere. Spherical signals with multiple peaks naturally arise in Diffusion MRI (dMRI), where…

图像与视频处理 · 电气工程与系统科学 2021-02-19 Axel Elaldi , Neel Dey , Heejong Kim , Guido Gerig

Diffusion magnetic resonance imaging (dMRI) and tractography provide means to study the anatomical structures within the white matter of the brain. When studying tractography data across subjects, it is usually necessary to align, i.e. to…

机器学习 · 统计学 2016-02-01 Thien Bao Nguyen , Emanuele Olivetti , Paolo Avesani

Diffusion MRI (dMRI) is essential for studying brain microstructure, but high-resolution imaging remains challenging due to the inherent trade-offs between acquisition time and signal-to-noise ratio (SNR). Conventional methods often…

图像与视频处理 · 电气工程与系统科学 2025-05-20 Yinzhe Wu , Jiahao Huang , Fanwen Wang , Mengze Gao , Congyu Liao , Guang Yang , Kawin Setsompop

Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR) is the only in vivo method to non-invasively examine the microstructure of the human heart. Current research in DT-CMR aims to improve the understanding of how the cardiac microstructure…

图像与视频处理 · 电气工程与系统科学 2026-05-19 Yinzhe Wu , Jiahao Huang , Fanwen Wang , Pedro Ferreira , Andrew Scott , Sonia Nielles-Vallespin , Guang Yang

Here we show a method of directing the edges of the connectomes, prepared from diffusion tensor imaging (DTI) datasets from the human brain. Before the present work, no high-definition directed braingraphs (or connectomes) were published,…

神经元与认知 · 定量生物学 2016-09-29 Balázs Szalkai , Csaba Kerepesi , Bálint Varga , Vince Grolmusz

Diffusion magnetic resonance imaging (MRI) has revealed important insights into white matter microstructure, but its application to gray matter remains comparatively less explored. Here, we investigate whether global patterns of gray-matter…

定量方法 · 定量生物学 2026-04-13 Lucas Z. Brito , Ryan P. Cabeen , David H. Laidlaw

Diffusion tensor imaging provides increased sensitivity to microstructural tissue changes compared to conventional anatomical imaging but also presents limited specificity. To tackle this problem, the DIAMOND model subdivides the voxel…

Our understanding of the human connectome is fundamentally limited by the resolution of diffusion MR images. Reconstructing a connectome's constituent neural pathways with tractography requires following a continuous field of fiber…

计算机视觉与模式识别 · 计算机科学 2023-12-12 Tyler Spears , P. Thomas Fletcher