相关论文: Electron FLASH platform for pre-clinical research:…

Purpose: LATTICE, a form of spatially fractionated radiation therapy that delivers high-dose peaks and low-dose valleys within the target, has been clinically utilized for treating bulky tumors. However, its application to…

We demonstrate a versatile technique for generating continuously wavelength-tunable laser waveforms, with mJ pulse energies and ultrashort pulse durations down to few-cycle in the ultraviolet C and visible spectral ranges. Using the…

A major theme in constraint-based modeling is unifying experimental data, such as biochemical information about the reactions that can occur in a system or the composition and localization of enzyme complexes, with highthroughput data…

FLASH is a widely available radiation magnetohydrodynamics code used for astrophysics, laboratory plasma science, high energy density physics, and inertial confinement fusion. Increasing interest in magnetically driven inertial confinement…

The use of very high energy electron (VHEE) beams for radiotherapy has been actively studied for over two decades due to their advantageous dose distribution, deep penetration depth and great potential of ultra-high dose-rate irradiation.…

Neoadjuvant chemotherapy (NAC) is a common therapy option before the main surgery for breast cancer. Response to NAC is monitored using follow-up dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Accurate prediction of NAC…

Timely access to laboratory values is critical for clinical decision-making, yet current approaches rely on invasive venous sampling and are intrinsically delayed. Electrocardiography (ECG), as a non-invasive and widely available signal,…

Purpose:The recently proposed IPO-IMPT framework allows simultaneous optimization of dose, dose rate, and LET for FLASH treatment planning. Finding solutions to IPO-IMPT is difficult due to computational intensiveness. Nevertheless, an…

We introduce a novel learning framework for accelerated Monte Carlo (MC) dose calculation termed Energy-Shifting. This approach leverages deep learning to synthesize highly complex polyenergetic dose distributions directly from simple…

Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) has attracted considerable attention due to its advantageous dose deposition characteristics, enabling deep penetration and the potential for ultra-high dose rate…

We propose a new concept of an electron source for ultrafast electron diffraction with sub-10~fs temporal resolution. Electrons are generated in a laser-plasma accelerator, able to deliver femtosecond electron bunches at 5 MeV energy with…

Dielectric loaded waveguides (DLWs) driven by multicycle terahertz (THz) pulses hold great promise as compact linear accelerators (LINACs) due to their ability to sustain higher breakdown fields at THz frequencies compared to conventional…

In order to dissipate long-lived radioactive waste, not only high ux proton accelerator but also electron linac have been proposed. A proton accelerator directly induces nuclear fission and mutation. On the other hand, electron beam has two…

We have recorded the coherent diffraction images of individual xenon clusters with intense extreme ultraviolet pulses to elucidate the influence of light-induced electronic changes on the diffraction pattern. Using the FLASH free-electron…

Minibeam and microbeam radiation therapy promise improved treatment outcomes through reduced normal tissue toxicity at better tumor control rates. The lack of suitable compact radiation sources limits the clinical application of minibeams…

The use of existing linacs, and in particular light source injectors, for free-electron laser (FEL) experiments is becoming more common due to the desire to test FELs at ever shorter wavelengths. The high-brightness, high-current beams…

The design and optimization of laser-Compton x-ray systems based on compact distributed charge accelerator structures can enable micron-scale imaging of disease and the concomitant production of beams of Very High Energy Electrons (VHEEs)…

At EuPRAXIA@SPARC_LAB, the unique combination of an advanced high-brightness RF injector and a plasma-based accelerator will drive a new multi-disciplinary user-facility. The facility, that is currently under study at INFN-LNF Laboratories…

In the framework of the upgrade of the SPARC_LAB facility at INFN-LNF, named EuPRAXIA@SPARC_LAB, a high gradient linac is foreseen. One of the most suitable options is to realize it in X-band. A preliminary design study of both accelerating…

Purpose: ECG and respiratory-gated preclinical cardiac CEST-MRI acquisitions are difficult due to variable saturation recovery with T1, RF interference in the ECG signal, and offset-to-offset variation in Z-magnetization and cardiac phase…