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Accurate and fast histological staining is crucial in histopathology, impacting diagnostic precision and reliability. Traditional staining methods are time-consuming and subjective, causing delays in diagnosis. Digital pathology plays a…

图像与视频处理 · 电气工程与系统科学 2023-07-06 Marian Boktor , James E. D. Tweel , Benjamin R. Ecclestone , Jennifer Ai Ye , Paul Fieguth , Parsin Haji Reza

Digitized Histological diagnosis is in increasing demand. However, color variations due to various factors are imposing obstacles to the diagnosis process. The problem of stain color variations is a well-defined problem with many proposed…

计算机视觉与模式识别 · 计算机科学 2018-04-06 M Tarek Shaban , Christoph Baur , Nassir Navab , Shadi Albarqouni

As the therapeutic target for Inflammatory Bowel Disease (IBD) shifts toward histologic remission, the accurate assessment of microscopic inflammation has become increasingly central for evaluating disease activity and response to…

Breast cancer is one of the leading causes of mortality in women. Early detection and treatment are imperative for improving survival rates, which have steadily increased in recent years as a result of more sophisticated…

计算机视觉与模式识别 · 计算机科学 2018-02-27 Sulaiman Vesal , Nishant Ravikumar , AmirAbbas Davari , Stephan Ellmann , Andreas Maier

Accurate classification of laryngeal vascular as benign or malignant is crucial for early detection of laryngeal cancer. However, organizations with limited access to laryngeal vascular images face challenges due to the lack of large and…

计算机视觉与模式识别 · 计算机科学 2025-01-17 Xinyi Fang , Xu Yang , Chak Fong Chong , Kei Long Wong , Yapeng Wang , Tiankui Zhang , Sio-Kei Im

Immunohistochemical (IHC) staining serves as a valuable technique for detecting specific antigens or proteins through antibody-mediated visualization. However, the IHC staining process is both time-consuming and costly. To address these…

计算机视觉与模式识别 · 计算机科学 2025-04-02 Zetong Chen , Yuzhuo Chen , Hai Zhong , Xu Qiao

Numerous deep learning based methods have been developed for nuclei segmentation for H&E images and have achieved close to human performance. However, direct application of such methods to another modality of images, such as…

计算机视觉与模式识别 · 计算机科学 2022-08-15 Roger Trullo , Quoc-Anh Bui , Qi Tang , Reza Olfati-Saber

Chemical staining methods are dependable but require extensive time, expensive chemicals, and raise environmental concerns. These challenges highlight the need for alternative solutions like virtual staining, which accelerates the…

图像与视频处理 · 电气工程与系统科学 2024-07-02 Mehdi Ounissi , Ilias Sarbout , Jean-Pierre Hugot , Christine Martinez-Vinson , Dominique Berrebi , Daniel Racoceanu

Histopathology images; microscopy images of stained tissue biopsies contain fundamental prognostic information that forms the foundation of pathological analysis and diagnostic medicine. However, diagnostics from histopathology images…

计算机视觉与模式识别 · 计算机科学 2019-10-30 Aïcha BenTaieb , Ghassan Hamarneh

This study evaluates the generalisation capabilities of state-of-the-art histopathology foundation models on out-of-distribution multi-stain autoimmune Immunohistochemistry datasets. We compare 13 feature extractor models, including…

计算机视觉与模式识别 · 计算机科学 2024-10-30 Amaya Gallagher-Syed , Elena Pontarini , Myles J. Lewis , Michael R. Barnes , Gregory Slabaugh

Histopathologists establish cancer grade by assessing histological structures, such as glands in prostate cancer. Yet, digital pathology pipelines often rely on grid-based tiling that ignores tissue architecture. This introduces irrelevant…

Cell detection, segmentation and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present…

Unsupervised and unpaired domain translation using generative adversarial neural networks, and more precisely CycleGAN, is state of the art for the stain translation of histopathology images. It often, however, suffers from the presence of…

计算机视觉与模式识别 · 计算机科学 2022-07-04 Nicolas Brieu , Felix J. Segerer , Ansh Kapil , Philipp Wortmann , Guenter Schmidt

Histopathological staining of human tissue is essential for disease diagnosis. Recent advances in virtual tissue staining technologies using artificial intelligence (AI) alleviate some of the costly and tedious steps involved in traditional…

图像与视频处理 · 电气工程与系统科学 2025-06-17 Luzhe Huang , Yuzhu Li , Nir Pillar , Tal Keidar Haran , William Dean Wallace , Aydogan Ozcan

While spatial transcriptomics (ST) has advanced our understanding of gene expression in tissue context, its high experimental cost limits its large-scale application. Predicting ST from pathology images is a promising, cost-effective…

计算机视觉与模式识别 · 计算机科学 2026-03-25 Zhiceng Shi , Changmiao Wang , Jun Wan , Wenwen Min

Immunohistochemistry (IHC) provides information on protein expression in tissue sections and is commonly used to support pathology diagnosis and disease triage. While AI models for H\&E-stained slides show promise, their applicability to…

With the increase in the use of deep learning for computer-aided diagnosis in medical images, the criticism of the black-box nature of the deep learning models is also on the rise. The medical community needs interpretable models for both…

图像与视频处理 · 电气工程与系统科学 2020-12-21 Mookund Sureka , Abhijeet Patil , Deepak Anand , Amit Sethi

Recently, various deep learning methods have shown significant successes in medical image analysis, especially in the detection of cancer metastases in hematoxylin and eosin (H&E) stained whole-slide images (WSIs). However, in order to…

图像与视频处理 · 电气工程与系统科学 2023-03-21 Yinsheng He , Xingyu Li

Different types of staining highlight different structures in organs, thereby assisting in diagnosis. However, due to the impossibility of repeated staining, we cannot obtain different types of stained slides of the same tissue area.…

图像与视频处理 · 电气工程与系统科学 2024-04-17 Zexin Li , Yiyang Lin , Zijie Fang , Shuyan Li , Xiu Li

Multiplex immunofluorescence and immunohistochemistry benefit patients by allowing cancer pathologists to identify several proteins expressed on the surface of cells, enabling cell classification, better understanding of the tumour…

计算机视觉与模式识别 · 计算机科学 2021-07-19 Jessica Cooper , In Hwa Um , Ognjen Arandjelović , David J Harrison