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Tissues commonly consist of cells embedded within a fibrous biopolymer network. Whereas cell-free reconstituted biopolymer networks typically soften under applied uniaxial compression, various tissues, including liver, brain, and fat, have…

Many biological materials consist of sparse networks of disordered fibres, embedded in a soft elastic matrix. The interplay between rigid and soft elements in such composite networks leads to mechanical properties that can go far beyond the…

软凝聚态物质 · 物理学 2017-04-26 Jan Maarten van Doorn , Luuk Lageschaar , Joris Sprakel , Jasper van der Gucht

Soft composite solids are made of inclusions dispersed within soft matrices. They are ubiquitous in nature and form the basis of many biological tissues. In the field of materials science, synthetic soft composites are promising candidates…

软凝聚态物质 · 物理学 2024-06-14 Yiqiu Zhao , Haitao Hu , Yulu Huang , Hanqing Liu , Caishan Yan , Chang Xu , Rui Zhang , Yifan Wang , Qin Xu

Semiflexible biopolymer networks are commonly found in biological systems, from the cytoskeleton of cells to the extracellular matrix. Such networks often naturally occur as composites, in which various components interact to generate rich…

软凝聚态物质 · 物理学 2018-01-18 D. L. Humphries , J. A. Grogan , E. A. Gaffney

Filamentous bio-materials such as fibrin or collagen networks exhibit an enormous stiffening of their elastic moduli upon large deformations. This pronounced nonlinear behavior stems from a significant separation between the stiffnesses…

软凝聚态物质 · 物理学 2019-05-21 Robbie Rens , Carlos Villarroel , Gustavo Düring , Edan Lerner

We report detailed theoretical investigations of the micro-mechanics and bulk elastic properties of composites consisting of randomly distributed stiff fibers embedded in an elastic matrix in two and three dimensions. Recent experiments…

软凝聚态物质 · 物理学 2013-05-29 Moumita Das , F. C. MacKintosh

Many biological tissues feature a heterogeneous network of fibers whose tensile and bending rigidity contribute substantially to these tissues' elastic properties. Rigidity percolation has emerged as a important paradigm for relating these…

Fibrous networks are ideal functional materials since they provide mechanical rigidity at low weight. Such structures are omnipresent in natural biomaterials from cells to tissues, as well as in man-made materials from polymeric composites…

Soft composite solids, comprising discrete inclusions embedded within a compliant matrix, are emerging candidates for engineering synthetic tissues and soft robotic materials. Current strategies for controlling their nonlinear mechanics,…

软凝聚态物质 · 物理学 2026-04-23 Yiqiu Zhao , Deng Pan , Yiming Pang , Jonathan Barés , Chang Xu , Che Liu , Haitao Hu , Yuliang Jin , Qin Xu

Disordered elastic networks provide a framework for describing a wide variety of physical systems, ranging from amorphous solids, through polymeric fibrous materials to confluent cell tissues. In many cases, such networks feature two widely…

软凝聚态物质 · 物理学 2024-09-02 Edan Lerner , Eran Bouchbinder

The elastic modulus $G$ of a polymer network depends notably on parameters such as the initial concentration of the monomers before the synthesis ($\rho_0$), the density of the cross-linker, or the topology of the network. Understanding how…

软凝聚态物质 · 物理学 2025-06-12 Jiting Tian , Jean-Louis Barrat , Walter Kob

Disordered filamentous networks with compliant crosslinks exhibit a low linear elastic shear modulus at small strains, but stiffen dramatically at high strains. Experiments have shown that the elastic modulus can increase by up to three…

Many fibrous materials are modeled as elastic networks featuring a substantial separation between the stiffness scales that characterize different microscopic deformation modes of the network's constituents. This scale separation has been…

软凝聚态物质 · 物理学 2024-05-22 Edan Lerner

In vitro collagen networks and in silico fiber network models are typically used to represent extracellular matrix in tissues. Such networks exhibit the phenomenon of strain-stiffening, or an increase in elastic modulus with increasing…

生物物理 · 物理学 2025-03-19 Amanda Parker , J. M. Schwarz

From bone and wood to concrete and carbon fibre, composites are ubiquitous natural and engineering materials. Eshelby's inclusion theory describes how macroscopic stress fields couple to isolated microscopic inclusions, allowing prediction…

Cellularized tissue and polymer networks can both transition from floppy to rigid as a function of their control parameters, and, yet, the two systems often mechanically interact, which may affect their respective rigidities. To study this…

细胞行为 · 定量生物学 2020-06-30 Amanda Parker , M. Cristina Marchetti , M. Lisa Manning , J. M. Schwarz

Investigation of inhomogeneities has wide applications in different areas of mechanics including the study of composite materials. Here, we analytically study an arbitrarily-shaped isotropic inhomogeneity embedded in a finite-sized…

软凝聚态物质 · 物理学 2018-11-20 Ehsan Ban

Disordered fibrous networks are ubiquitous in nature as major structural components of living cells and tissues. The mechanical stability of networks generally depends on the degree of connectivity: only when the average number of…

生物物理 · 物理学 2016-06-22 A. Sharma , A. J. Licup , R. Rens , M. Sheinman , K. A. Jansen , G. H. Koenderink , F. C. MacKintosh

We present theoretical and experimental studies of the elastic response of fibrous networks subjected to uniaxial strain. Uniaxial compression or extension is applied to extracellular networks of fibrin and collagen using a shear rheometer…

We study the mechanical stiffening behavior in two-dimensional (2D) cross-linked networks of semiflexible biopolymer filaments under simple shear. Filamental constituents immersed in a fluid undergo thermally excited bending motions.…

生物物理 · 物理学 2007-05-23 T. Van Dillen , P. R. Onck , E. Van der Giessen
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