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Lyophilization (aka freeze drying) is a typical process in pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications to mRNA vaccines. While extensive efforts have been…

计算工程、金融与科学 · 计算机科学 2025-12-03 Prakitr Srisuma , Gang Chen , Richard D. Braatz

The vitrification of aqueous solutions through rapid cooling is a remarkable achievement that launched the field of cryo-electron microscopy (cryo-EM) and has enabled the cryopreservation of biological specimens. For judging the feasibility…

化学物理 · 物理学 2024-07-02 Nathan J. Mowry , Constantin R. Kruger , Marcel Drabbels , Ulrich J. Lorenz

Image processing and pattern recognition offer a useful and versatile method for optically characterizing drops of a colloidal solution during the drying process and in its final state. This paper exploits image processing techniques…

软凝聚态物质 · 物理学 2020-02-11 Anusuya Pal , Amalesh Gope , Germano S. Iannacchione

The proneness of water to crystallize is a major obstacle to understanding its putative exotic behavior in the supercooled state. It also represents a strong practical limitation to cryopreservation of biological systems. Adding some…

This article presents a highly efficient optimal control algorithm and policies for lyophilization (also known as freeze drying). The optimal solutions and control policies are derived using an extended version of the simulation-based…

最优化与控制 · 数学 2025-09-16 Prakitr Srisuma , Richard D. Braatz

This paper tackles the problem of passive gaze estimation using both event and frame data. Considering the inherently different physiological structures, it is intractable to accurately estimate gaze purely based on a given state. Thus, we…

计算机视觉与模式识别 · 计算机科学 2024-07-01 Jiading Li , Zhiyu Zhu , Jinhui Hou , Junhui Hou , Jinjian Wu

Continuous soil-moisture measurements provide a direct lens on subsurface hydrological processes, notably the post-rainfall "drydown" phase. Because these records consist of distinct, segment-specific behaviours whose forms and scales vary…

应用统计 · 统计学 2025-09-17 Mengyi Gong , Christopher Nemeth , Rebecca Killick , Peter Strauss , John Quinton

Drying colloidal droplets have a wide range of applications from medical diagnostics to coatings for industries. This paper explores the effects of the substrate temperature (ranging from $25$ to $55 ^{\circ}$C) and various initial…

软凝聚态物质 · 物理学 2021-05-14 Anusuya Pal , Amalesh Gope , Germano S. Iannacchione

We demonstrate the reliability and applicability of THz imaging for destructive and non-destructive water status monitoring of winter wheat leaves. Based on the measured THz transmission amplitude, we find that the water loss in the distal…

生物物理 · 物理学 2020-08-28 Bin Li , Rong Wang , Jianjun Ma

A particle-water discrete element based approach to describe water movement in partially saturated granular media is presented and tested. Water potential is governed by both capillary bridges, dominant at low saturations, and the pressure…

软凝聚态物质 · 物理学 2013-12-05 Yixiang Gan , Federico Maggi , Giuseppe Buscarnera , Itai Einav

Fertilization is commonly used to increase harvests. The lack of knowledge of soil properties and the excessive use of fertilizers can result in overfertilization. Current sensor technology is able to measure the concentrations of some of…

系统与控制 · 电气工程与系统科学 2023-04-13 Patrick Schmidt , Arne-Jens Hempel , Stefan Streif

In order for biomass drying processes to be efficient, it is crucial to achieve the target residual water content within a close margin, since more conservative drying would result in a waste of energy. A method for a reliable estimation of…

最优化与控制 · 数学 2020-03-30 Marc Oliver Berner , Viktor Scherer , Martin Mönnigmann

Real-time and accurate monitoring of humidity and pH is of great significance in daily life and industrial production. Existing humidity and pH measurement suffer from limitations such as low sensitivity, signal crosstalk, complex system…

应用物理 · 物理学 2025-11-07 Jia Liu , Jiawen Zhang , Xiyu Liu , Qi Meng , Riming Xu , Jin Wang

Moisture content (MC) estimation is important in the manufacturing process of drying bulky filter media products as it is the prerequisite for drying optimization. In this study, a dataset collected by performing 161 drying industrial…

机器学习 · 计算机科学 2023-03-29 Christian Remi Wewer , Alexandros Iosifidis

We present a simple method for fast and cheap thermal analysis on supercooled glass-forming liquids. This "Thermalization Calorimetry" technique is based on monitoring the temperature and its rate of change during heating or cooling of a…

In this paper, we present the latest results on the measurement of the Boltzmann constant kB, by laser spectroscopy of ammonia at 10 ?m. The Doppler absorption profile of a ro-vibrational line of an NH3 gas sample at thermal and pressure…

Context: In a freeze drying (FD) process, an accurate observation and control of the process parameters at critical stages are at high importance. Particularly accurate and timely identification of the critical temperature (TC) at the end…

图像与视频处理 · 电气工程与系统科学 2024-06-17 Ahmet Orun , Anand Vadesa , Geoff Smith

We determine quantum precision limits for estimation of damping constants and temperature of lossy bosonic channels. A direct application would be the use of light for estimation of the absorption and the temperature of a transparent slab.…

量子物理 · 物理学 2020-09-16 Jiaxuan Wang , Luiz Davidovich , Girish Saran Agarwal

Chronoamperometry (CA) is a fundamental electrochemical technique used for quantifying redox-active species. However, in room-temperature ionic liquids (RTILs), the high viscosity and slow mass transport often lead to extended measurement…

机器人学 · 计算机科学 2025-06-06 Kordel K. France

Effect of confinement on the liquid-liquid transition of water are studied by simulations in the Gibbs ensemble. Upon cooling along the liquid-vapor coexistence curve, confined water undergoes transition from normal to strongly tetrahedral…

软凝聚态物质 · 物理学 2007-05-23 Ivan Brovchenko , Alla Oleinikova
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