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Artificial intelligence (AI) has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images (WSIs). However, current methods are computationally inefficient, processing thousands of redundant…

The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning…

This report represents a roadmap for integrating Artificial Intelligence (AI)-based image analysis algorithms into existing Radiology workflows such that: (1) radiologists can significantly benefit from enhanced automation in various…

图像与视频处理 · 电气工程与系统科学 2019-10-16 Engin Dikici , Matthew Bigelow , Luciano M. Prevedello , Richard D. White , Barbaros Selnur Erdal

Image segmentation is a fundamental problem in biomedical image analysis. Recent advances in deep learning have achieved promising results on many biomedical image segmentation benchmarks. However, due to large variations in biomedical…

计算机视觉与模式识别 · 计算机科学 2017-06-16 Lin Yang , Yizhe Zhang , Jianxu Chen , Siyuan Zhang , Danny Z. Chen

Graphical models are commonly used to discover associations within gene or protein networks for complex diseases such as cancer. Most existing methods estimate a single graph for a population, while in many cases, researchers are interested…

Pancreatic cancers have one of the worst prognoses compared to other cancers, as they are diagnosed when cancer has progressed towards its latter stages. The current manual histological grading for diagnosing pancreatic adenocarcinomas is…

图像与视频处理 · 电气工程与系统科学 2022-06-20 Biraja Ghoshal , Bhargab Ghoshal , Allan Tucker

Cancer is one of the leading causes of death worldwide. Fast and safe early-stage, pre- and intra-operative diagnostics can significantly contribute to successful cancer identification and treatment. Artificial intelligence has played an…

组织与器官 · 定量生物学 2022-08-10 Marina Zajnulina

We present an applied study in cancer genomics for integrating data and inferences from laboratory experiments on cancer cell lines with observational data obtained from human breast cancer studies. The biological focus is on improving…

应用统计 · 统计学 2010-10-07 Daniel Merl , Julia Ling-Yu Chen , Jen-Tsan Chi , Mike West

Graphical models are ubiquitous tools to describe the interdependence between variables measured simultaneously such as large-scale gene or protein expression data. Gaussian graphical models (GGMs) are well-established tools for…

统计方法学 · 统计学 2020-01-09 Nilabja Guha , Veera Baladandayuthapani , Bani K. Mallick

Artificial intelligence may assist healthcare systems in meeting increasing demand for pathology services while maintaining diagnostic quality and reducing turnaround time and costs. We aimed to investigate the performance of an…

Segmentation of Prostate Cancer (PCa) tissues from Gleason graded histopathology images is vital for accurate diagnosis. Although deep learning (DL) based segmentation methods achieve state-of-the-art accuracy, they rely on large datasets…

图像与视频处理 · 电气工程与系统科学 2021-10-04 Dwarikanath Mahapatra

Prostate cancer (PCa) is the second deadliest form of cancer in males, and it can be clinically graded by examining the structural representations of Gleason tissues. This paper proposes \RV{a new method} for segmenting the Gleason tissues…

计算机视觉与模式识别 · 计算机科学 2021-07-27 Taimur Hassan , Bilal Hassan , Ayman El-Baz , Naoufel Werghi

Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…

Prostate cancer is the most prevalent cancer among men in Western countries, with 1.1 million new diagnoses every year. The gold standard for the diagnosis of prostate cancer is a pathologists' evaluation of prostate tissue. To potentially…

图像与视频处理 · 电气工程与系统科学 2020-10-23 Hans Pinckaers , Wouter Bulten , Jeroen van der Laak , Geert Litjens

Multi-state models of cancer natural history are widely used for designing and evaluating cancer early detection strategies. Calibrating such models against longitudinal data from screened cohorts is challenging, especially when fitting…

统计计算 · 统计学 2025-08-14 Raphael Morsomme , Shannon Holloway , Marc Ryser , Jason Xu

Recently deep neural networks, which require a large amount of annotated samples, have been widely applied in nuclei instance segmentation of H\&E stained pathology images. However, it is inefficient and unnecessary to label all pixels for…

计算机视觉与模式识别 · 计算机科学 2022-12-21 Wei Lou , Haofeng Li , Guanbin Li , Xiaoguang Han , Xiang Wan

Developing an AI-assisted gland segmentation method from histology images is critical for automatic cancer diagnosis and prognosis; however, the high cost of pixel-level annotations hinders its applications to broader diseases. Existing…

计算机视觉与模式识别 · 计算机科学 2022-06-28 Yi Li , Yiduo Yu , Yiwen Zou , Tianqi Xiang , Xiaomeng Li

There has been a growing interest in creating intelligent diagnostic systems to assist medical professionals in analyzing and processing big data for the treatment of incurable diseases. One of the key challenges in this field is detecting…

图像与视频处理 · 电气工程与系统科学 2023-08-29 Yassine Habchi , Yassine Himeur , Hamza Kheddar , Abdelkrim Boukabou , Shadi Atalla , Ammar Chouchane , Abdelmalik Ouamane , Wathiq Mansoor

Breast cancer is one of the most prevalent cancers worldwide and pathologists are closely involved in establishing a diagnosis. Tools to assist in making a diagnosis are required to manage the increasing workload. In this context,…

A comprehensive artificial intelligence system needs to not only perceive the environment with different `senses' (e.g., seeing and hearing) but also infer the world's conditional (or even causal) relations and corresponding uncertainty.…

机器学习 · 统计学 2021-01-07 Hao Wang , Dit-Yan Yeung