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In the analysis of single-cell RNA sequencing data, researchers often characterize the variation between cells by estimating a latent variable, such as cell type or pseudotime, representing some aspect of the individual cell's state. They…

统计方法学 · 统计学 2022-10-19 Anna Neufeld , Lucy L. Gao , Joshua Popp , Alexis Battle , Daniela Witten

We propose data thinning, an approach for splitting an observation into two or more independent parts that sum to the original observation, and that follow the same distribution as the original observation, up to a (known) scaling of a…

统计方法学 · 统计学 2023-11-22 Anna Neufeld , Ameer Dharamshi , Lucy L. Gao , Daniela Witten

Suppose we observe a random vector $X$ from some distribution $P$ in a known family with unknown parameters. We ask the following question: when is it possible to split $X$ into two parts $f(X)$ and $g(X)$ such that neither part is…

统计方法学 · 统计学 2023-12-12 James Leiner , Boyan Duan , Larry Wasserman , Aaditya Ramdas

Clustering is part of unsupervised analysis methods that consist in grouping samples into homogeneous and separate subgroups of observations also called clusters. To interpret the clusters, statistical hypothesis testing is often used to…

统计方法学 · 统计学 2022-10-25 Benjamin Hivert , Denis Agniel , Rodolphe Thiébaut , Boris P Hejblum

Leiner et al. [2023] introduce an important generalization of sample splitting, which they call data fission. They consider two cases of data fission: P1 fission and P2 fission. While P1 fission is extremely useful and easy to use, Leiner…

统计方法学 · 统计学 2024-09-06 Anna Neufeld , Ameer Dharamshi , Lucy L. Gao , Daniela Witten , Jacob Bien

Testing for differences in features between clusters in various applications often leads to inflated false positives when practitioners use the same dataset to identify clusters and then test features, an issue commonly known as ``double…

统计方法学 · 统计学 2024-10-10 Lijun Wang , Yingxin Lin , Hongyu Zhao

While clustering is ubiquitously used across science and industry, uncertainty in cluster assignments is rarely quantified with rigorous guarantees. We propose a novel conformal inference framework for clustering that returns confidence…

统计方法学 · 统计学 2026-04-13 YoonHaeng Hur , Anirban Nath , Genevera Allen

In recent years, advances in high throughput sequencing technology have led to a need for specialized methods for the analysis of digital gene expression data. While gene expression data measured on a microarray take on continuous values…

应用统计 · 统计学 2012-02-29 Daniela M. Witten

Clustering is a core task in machine learning with wide-ranging applications in data mining and pattern recognition. However, its unsupervised nature makes it inherently challenging. Many existing clustering algorithms suffer from critical…

机器学习 · 计算机科学 2025-07-29 Ahmed Shokry , Ayman Khalafallah

Statistical matching is a technique for integrating two or more data sets when information available for matching records for individual participants across data sets is incomplete. Statistical matching can be viewed as a missing data…

统计方法学 · 统计学 2015-10-14 Jae-kwang Kim , Emily Berg , Taesung Park

Clustering analysis of functional data, which comprises observations that evolve continuously over time or space, has gained increasing attention across various scientific disciplines. Practical applications often involve functional data…

统计方法学 · 统计学 2024-06-19 Tingyu Zhu , Lan Xue , Carmen Tekwe , Keith Diaz , Mark Benden , Roger Zoh

The clustering of bounded data presents unique challenges in statistical analysis due to the constraints imposed on the data values. This paper introduces a novel method for model-based clustering specifically designed for bounded data.…

统计方法学 · 统计学 2025-05-16 Luca Scrucca

The analysis of single-cell RNA sequencing (scRNA-seq) data often involves fitting a latent variable model to learn a low-dimensional representation for the cells. Validating such a model poses a major challenge. If we could sequence the…

统计方法学 · 统计学 2023-07-25 Anna Neufeld , Joshua Popp , Lucy L. Gao , Alexis Battle , Daniela Witten

High-dimensional clustering analysis is a challenging problem in statistics and machine learning, with broad applications such as the analysis of microarray data and RNA-seq data. In this paper, we propose a new clustering procedure called…

统计方法学 · 统计学 2022-10-31 Tianqi Liu , Yu Lu , Biqing Zhu , Hongyu Zhao

The goal of data clustering is to partition data points into groups to minimize a given objective function. While most existing clustering algorithms treat each data point as vector, in many applications each datum is not a vector but a…

机器学习 · 统计学 2017-03-16 Dinh Phung , Ba-Ngu Bo

Constrained clustering has gained significant attention in the field of machine learning as it can leverage prior information on a growing amount of only partially labeled data. Following recent advances in deep generative models, we…

机器学习 · 计算机科学 2022-02-02 Laura Manduchi , Kieran Chin-Cheong , Holger Michel , Sven Wellmann , Julia E. Vogt

Clustering is a widely used technique in data mining applications for discovering patterns in underlying data. Most traditional clustering algorithms are limited to handling datasets that contain either numeric or categorical attributes.…

人工智能 · 计算机科学 2007-05-23 Zengyou He , Xiaofei Xu , Shengchun Deng

Data fusion techniques integrate information from heterogeneous data sources to improve learning, generalization, and decision making across data sciences. In causal inference, these methods leverage rich observational data to improve…

统计方法学 · 统计学 2025-06-02 Quinn Lanners , Cynthia Rudin , Alexander Volfovsky , Harsh Parikh

Spectral clustering requires the time-consuming decomposition of the Laplacian matrix of the similarity graph, thus limiting its applicability to large datasets. To improve the efficiency of spectral clustering, a top-down approach was…

机器学习 · 计算机科学 2024-12-19 Zhichang Xu , Zhiguo Long , Hua Meng

We introduce a technique called graph fission which takes in a graph which potentially contains only one observation per node (whose distribution lies in a known class) and produces two (or more) independent graphs with the same node/edge…

统计方法学 · 统计学 2024-01-30 James Leiner , Aaditya Ramdas
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