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Understanding the spatiotemporal dynamics of disease progression in relation to transcriptomic profiles provides key insights into complex conditions such as Alzheimer disease. To enable such investigations, STARmap PLUS technology offers…

应用统计 · 统计学 2026-04-28 Zitian Wu , Susmita Datta , Arkaprava Roy

Solving 3D medical inverse problems such as image restoration and reconstruction is crucial in modern medical field. However, the curse of dimensionality in 3D medical data leads mainstream volume-wise methods to suffer from high resource…

图像与视频处理 · 电气工程与系统科学 2024-05-27 Jia He , Bonan Li , Ge Yang , Ziwen Liu

Latent diffusion models offer an attractive alternative to discrete diffusion for non-autoregressive text generation by operating on continuous text representations and denoising entire sequences in parallel. The major challenge in latent…

Learning the dynamics of spatiotemporal events is a fundamental problem. Neural point processes enhance the expressivity of point process models with deep neural networks. However, most existing methods only consider temporal dynamics…

机器学习 · 计算机科学 2024-12-10 Zihao Zhou , Xingyi Yang , Ryan Rossi , Handong Zhao , Rose Yu

Deep learning and generative models are advancing rapidly, with synthetic data increasingly being integrated into training pipelines for downstream analysis tasks. However, in medical imaging, their adoption remains constrained by the…

Implicit visual knowledge in a large latent diffusion model (LLDM) pre-trained on natural images is rich and hypothetically universal to natural and medical images. To test this hypothesis from a practical perspective, we propose a novel…

图像与视频处理 · 电气工程与系统科学 2024-07-08 Ziqi Gao , S. Kevin Zhou

Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…

定量方法 · 定量生物学 2021-05-31 Nanyan Zhu , Chen Liu , Xinyang Feng , Dipika Sikka , Sabrina Gjerswold-Selleck , Scott A. Small , Jia Guo

Introduction: The blood-brain barrier (BBB) protects the central nervous system but prevents most neurotherapeutics from reaching effective concentrations in the brain. BBB-penetrating peptides (BBBPs) offer a promising strategy for brain…

定量方法 · 定量生物学 2025-12-15 Kaijie Wang , Le Yin , Aodi Tian , Zhiqiang Wei , Zai Yang , Min Han , Qichun Wei , Sheng Wang

Brain network analysis is essential for diagnosing and intervention for Alzheimer's disease (AD). However, previous research relied primarily on specific time-consuming and subjective toolkits. Only few tools can obtain the structural brain…

人工智能 · 计算机科学 2023-03-14 Xuhang Chen , Baiying Lei , Chi-Man Pun , Shuqiang Wang

Timely identification and accurate risk stratification of cardiovascular disease (CVD) remain essential for reducing global mortality. While existing prediction models primarily leverage structured data, unstructured clinical notes contain…

计算与语言 · 计算机科学 2025-07-16 Haowei Yang , Ziyu Shen , Junli Shao , Luyao Men , Xinyue Han , Jing Dong

Diffusion Language Models (DLMs) promise parallel generation and bidirectional context, yet they underperform autoregressive (AR) models in both likelihood modeling and generated text quality. We identify that this performance gap arises…

计算与语言 · 计算机科学 2025-05-27 Litu Rout , Constantine Caramanis , Sanjay Shakkottai

Effectively addressing the challenge of industrial Anomaly Detection (AD) necessitates an ample supply of defective samples, a constraint often hindered by their scarcity in industrial contexts. This paper introduces a novel algorithm…

计算机视觉与模式识别 · 计算机科学 2024-03-27 Hanxi Li , Zhengxun Zhang , Hao Chen , Lin Wu , Bo Li , Deyin Liu , Mingwen Wang

LLMs for clinical decision support often fail under small but clinically meaningful input shifts such as masking a symptom or negating a finding, despite high performance on static benchmarks. These reasoning failures frequently go…

机器学习 · 计算机科学 2025-07-30 Raj Krishnan Vijayaraj

While latent diffusion models (LDMs), such as Stable Diffusion, are designed for high-resolution (HR) image generation, they often struggle with significant structural distortions when generating images at resolutions higher than their…

计算机视觉与模式识别 · 计算机科学 2025-12-09 Boyuan Cao , Jiaxin Ye , Yujie Wei , Hongming Shan

Diffusion MRI (dMRI) is an advanced imaging technique characterizing tissue microstructure and white matter structural connectivity of the human brain. The demand for high-quality dMRI data is growing, driven by the need for better…

图像与视频处理 · 电气工程与系统科学 2024-08-26 Xi Zhu , Wei Zhang , Yijie Li , Lauren J. O'Donnell , Fan Zhang

Magnetic Resonance (MR) imaging plays an essential role in contemporary clinical diagnostics. It is increasingly integrated into advanced therapeutic workflows, such as hybrid Positron Emission Tomography/Magnetic Resonance (PET/MR) imaging…

图像与视频处理 · 电气工程与系统科学 2025-07-17 Jiaxu Zheng , Meiman He , Xuhui Tang , Xiong Wang , Tuoyu Cao , Tianyi Zeng , Lichi Zhang , Chenyu You

Diffusion-based language models (dLLMs) have emerged as a promising alternative to autoregressive language models, offering the potential for parallel token generation and bidirectional context modeling. However, harnessing this flexibility…

计算与语言 · 计算机科学 2026-05-28 Jiyeon Kim , Sungik Choi , Yongrae Jo , Moontae Lee , Minjoon Seo

Existing methods for arterial blood pressure (BP) estimation directly map the input physiological signals to output BP values without explicitly modeling the underlying temporal dependencies in BP dynamics. As a result, these models suffer…

机器学习 · 计算机科学 2018-01-16 Peng Su , Xiao-Rong Ding , Yuan-Ting Zhang , Jing Liu , Fen Miao , Ni Zhao

Despite the increasing use of deep learning in medical image segmentation, the limited availability of annotated training data remains a major challenge due to the time-consuming data acquisition and privacy regulations. In the context of…

图像与视频处理 · 电气工程与系统科学 2024-06-11 Aghiles Kebaili , Jérôme Lapuyade-Lahorgue , Pierre Vera , Su Ruan

Time series generation is a crucial research topic in the area of decision-making systems, which can be particularly important in domains like autonomous driving, healthcare, and, notably, robotics. Recent approaches focus on learning in…

机器学习 · 计算机科学 2024-09-16 Jian Qian , Bingyu Xie , Biao Wan , Minhao Li , Miao Sun , Patrick Yin Chiang