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I describe a framework for adaptive scientific exploration based on iterating an Observation--Inference--Design cycle that allows adjustment of hypotheses and observing protocols in response to the results of observation on-the-fly, as data…

天体物理学 · 物理学 2009-11-10 Thomas J. Loredo

We design a new myopic strategy for a wide class of sequential design of experiment (DOE) problems, where the goal is to collect data in order to to fulfil a certain problem specific goal. Our approach, Myopic Posterior Sampling (MPS), is…

This paper focuses on the Bayesian Network Propensity Score (BNPS), a novel approach for estimating treatment effects in observational studies characterized by unknown (and likely unbalanced) designs and complex dependency structures among…

In the drug discovery process, where experiments can be costly and time-consuming, computational models that predict drug-target interactions are valuable tools to accelerate the development of new therapeutic agents. Estimating the…

机器学习 · 计算机科学 2024-07-22 Hannah Rosa Friesacher , Ola Engkvist , Lewis Mervin , Yves Moreau , Adam Arany

The Bayesian expected power (BEP) has become increasingly popular in sample size determination and assessment of the probability of success (POS) for a future trial. The BEP takes into consideration the uncertainty around the parameters…

统计方法学 · 统计学 2020-07-01 Fang Liu

We propose a flexible Bayesian approach for estimating the joint density of a multivariate outcome of interest in the presence of categorical covariates. Leveraging a Gaussian copula framework, our method effectively captures the dependence…

统计方法学 · 统计学 2026-04-10 Giovanni Toto , Peter Müller , Abhra Sarkar

Major advances have been made regarding the utilization of artificial intelligence in health care. In particular, deep learning approaches have been successfully applied for automated and assisted disease diagnosis and prognosis based on…

统计方法学 · 统计学 2020-03-24 Max Westphal , Antonia Zapf , Werner Brannath

Credible microscopic traffic simulation requires car-following models that capture both the average response and the substantial variability observed across drivers and situations. However, most data-driven calibrations remain…

应用统计 · 统计学 2026-02-06 Menglin Kong , Chengyuan Zhang , Lijun Sun

Approximate Bayesian computation (ABC) is a class of algorithmic methods in Bayesian inference using statistical summaries and computer simulations. ABC has become popular in evolutionary genetics and in other branches of biology. However…

统计计算 · 统计学 2011-05-03 Olivier Francois , Guillaume Laval

We propose a novel diverse feature selection method based on determinantal point processes (DPPs). Our model enables one to flexibly define diversity based on the covariance of features (similar to orthogonal matching pursuit) or…

Parameter tuning in real-world experiments is constrained by the limited evaluation budget available on hardware. The path-following controller studied in this paper reflects a typical situation in nonlinear geometric controller, where…

机器人学 · 计算机科学 2026-05-28 Zhewen Zheng , Wenjing Cao , Hongkang Yu , Mo Chen , Takashi Suzuki

In this paper, we aim at solving a class of multiple testing problems under the Bayesian sequential decision framework. Our motivating application comes from binary labeling tasks in crowdsourcing, where the requestor needs to…

统计方法学 · 统计学 2017-08-29 Xiaoou Li , Yunxiao Chen , Xi Chen , Jingchen Liu , Zhiliang Ying

We develop an algorithm to solve the Bottleneck Assignment Problem (BAP) that is amenable to having computation distributed over a network of agents. This consists of exploring how each component of the algorithm can be distributed, with a…

最优化与控制 · 数学 2020-11-20 Mitchell Khoo , Tony A. Wood , Chris Manzie , Iman Shames

Testing for pairwise independence for the case where the number of variables may be of the same size or even larger than the sample size has received increasing attention in the recent years. We contribute to this branch of the literature…

统计理论 · 数学 2024-09-18 Axel Bücher , Cambyse Pakzad

A Bayesian network is a widely used probabilistic graphical model with applications in knowledge discovery and prediction. Learning a Bayesian network (BN) from data can be cast as an optimization problem using the well-known…

人工智能 · 计算机科学 2020-09-01 Zhenyu A. Liao , Charupriya Sharma , James Cussens , Peter van Beek

This paper proposes a novel solution to spam detection inspired by a model of the adaptive immune system known as the crossregulation model. We report on the testing of a preliminary algorithm on six e-mail corpora. We also compare our…

人工智能 · 计算机科学 2008-12-05 Alaa Abi-Haidar , Luis M. Rocha

Understanding the basins of attraction (BoA) is often a paramount consideration for nonlinear systems. Most existing approaches to determining a high-resolution BoA require prior knowledge of the system's dynamical model (e.g., differential…

机器学习 · 计算机科学 2022-05-12 Xue-She Wang , Samuel A. Moore , James D. Turner , Brian P. Mann

Motivation: Modern biobanks, with unprecedented sample sizes and phenotypic diversity, have become foundational resources for genomic studies, enabling powerful cross-phenotype and population-scale analyses. As studies grow in complexity,…

应用统计 · 统计学 2026-04-30 Yiran Li , John Whittaker , Sylvia Richardson , Helene Ruffieux

This paper provides a simple, yet reliable, alternative to the (Bayesian) estimation of large multivariate VARs with time variation in the conditional mean equations and/or in the covariance structure. With our new methodology, the original…

计量经济学 · 经济学 2020-01-01 Mike Tsionas , Marwan Izzeldin , Lorenzo Trapani

Precision matrix, which is the inverse of covariance matrix, plays an important role in statistics, as it captures the partial correlation between variables. Testing the equality of two precision matrices in high dimensional setting is a…

统计方法学 · 统计学 2018-10-23 Mingjuan Zhang , Yong He , Cheng Zhou , Xinsheng Zhang