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Particle picking is a time-consuming step in single-particle analysis and often requires significant interventions from users, which has become a bottleneck for future automated electron cryo-microscopy (cryo-EM). Here we report a deep…

定量方法 · 定量生物学 2016-05-09 Feng Wang , Huichao Gong , Gaochao liu , Meijing Li , Chuangye Yan , Tian Xia , Xueming Li , Jianyang Zeng

Discrete image registration can be a strategy to reconstruct signals from samples corrupted by blur and noise. We examine superresolution and discrete image registration for one-dimensional spatially-limited piecewise constant functions…

计算机视觉与模式识别 · 计算机科学 2025-02-18 Serap A. Savari

Cryogenic electron microscopy is widely used in structural biology, but its resolution is often limited by the dynamics of the macromolecule. Here, we developed a refinement protocol based on Gaussian mixture models that integrates particle…

定量方法 · 定量生物学 2023-08-31 Muyuan Chen , Michael F. Schmid , Wah Chiu

We consider the problem of coded distributed computing where a large linear computational job, such as a matrix multiplication, is divided into $k$ smaller tasks, encoded using an $(n,k)$ linear code, and performed over $n$ distributed…

信息论 · 计算机科学 2021-10-06 Mahdi Soleymani , Mohammad Vahid Jamali , Hessam Mahdavifar

Iterative phase retrieval algorithms typically employ projections onto constraint subspaces to recover the unknown phases in the Fourier transform of an image, or, in the case of x-ray crystallography, the electron density of a molecule.…

数值分析 · 数学 2025-10-20 Veit Elser

The image deblurring problem consists of reconstructing images from blur and noise contaminated available data. In this AMS Notices article, we provide an overview of some well known numerical linear algebra techniques that are use for…

数值分析 · 数学 2022-01-25 David Austin , Malena I. Español , Mirjeta Pasha

Image compression is a method to remove spatial redundancy between adjacent pixels and reconstruct a high-quality image. In the past few years, deep learning has gained huge attention from the research community and produced promising image…

图像与视频处理 · 电气工程与系统科学 2021-09-07 Khawar Islam , L. Minh Dang , Sujin Lee , Hyeonjoon Moon

In this paper we study constrained subspace approximation problem. Given a set of $n$ points $\{a_1,\ldots,a_n\}$ in $\mathbb{R}^d$, the goal of the {\em subspace approximation} problem is to find a $k$ dimensional subspace that best…

数据结构与算法 · 计算机科学 2025-04-30 Aditya Bhaskara , Sepideh Mahabadi , Madhusudhan Reddy Pittu , Ali Vakilian , David P. Woodruff

In this paper we propose a novel algorithm to combine two or more cellular complexes, providing a minimal fragmentation of the cells of the resulting complex. We introduce here the idea of arrangement generated by a collection of cellular…

计算几何 · 计算机科学 2017-08-29 Alberto Paoluzzi , Vadim Shapiro , Antonio DiCarlo

Macromolecules change their shape (conformation) in the process of carrying out their functions. The imaging by cryo-electron microscopy of rapidly-frozen, individual copies of macromolecules (single particles) is a powerful and general…

生物大分子 · 定量生物学 2022-11-22 Bogdan Toader , Fred J. Sigworth , Roy R. Lederman

We develop in this paper a novel intrinsic classification algorithm -- multi-frequency class averaging (MFCA) -- for classifying noisy projection images obtained from three-dimensional cryo-electron microscopy (cryo-EM) by the similarity…

图像与视频处理 · 电气工程与系统科学 2021-07-07 Yifeng Fan , Tingran Gao , Zhizhen Zhao

Orbit recovery problems are a class of problems that often arise in practice and various forms. In these problems, we aim to estimate an unknown function after being distorted by a group action and observed via a known operator. Typically,…

统计方法学 · 统计学 2024-01-31 Yuehaw Khoo , Sounak Paul , Nir Sharon

Constrained codes are used to prevent errors from occurring in various data storage and data transmission systems. They can help in increasing the storage density of magnetic storage devices, in managing the lifetime of electronic storage…

信息论 · 计算机科学 2022-09-07 Ahmed Hareedy , Beyza Dabak , Robert Calderbank

Data clustering has received a lot of attention and numerous methods, algorithms and software packages are available. Among these techniques, parametric finite-mixture models play a central role due to their interesting mathematical…

计算机视觉与模式识别 · 计算机科学 2017-01-31 Israel D. Gebru , Xavier Alameda-Pineda , Florence Forbes , Radu Horaud

Recently, convolutional auto-encoders (CAE) were introduced for image coding. They achieved performance improvements over the state-of-the-art JPEG2000 method. However, these performances were obtained using massive CAEs featuring a large…

图像与视频处理 · 电气工程与系统科学 2022-09-13 Cyprien Gille , Frédéric Guyard , Marc Antonini , Michel Barlaud

Enhancing cryogenic electron microscopy (cryo-EM) 3D density maps at intermediate resolution (4-8 {\AA}) is crucial in protein structure determination. Recent advances in deep learning have led to the development of automated approaches for…

计算机视觉与模式识别 · 计算机科学 2025-05-16 Chenwei Zhang , Khanh Dao Duc

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

计算机视觉与模式识别 · 计算机科学 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot

We present an ordinary differential equations approach to the analysis of algorithms for constructing $l_1$ minimizing solutions to underdetermined linear systems of full rank. It involves a relaxed minimization problem whose minimum is…

数值分析 · 数学 2015-06-04 Miguel Moscoso , Alexei Novikov , George Papanicolaou , Lenya Ryzhik

Clustering under pairwise constraints is an important knowledge discovery tool that enables the learning of appropriate kernels or distance metrics to improve clustering performance. These pairwise constraints, which come in the form of…

机器学习 · 计算机科学 2022-03-24 Benedikt Boecking , Vincent Jeanselme , Artur Dubrawski

Cryo-electron tomography (cryo-ET) has emerged as a powerful tool for studying the structural heterogeneity of proteins and their complexes, offering insights into macromolecular dynamics directly within cells. Driven by recent…

生物大分子 · 定量生物学 2025-07-01 Jackson Carrion , Joseph H. Davis
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