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We introduce a general framework for monitoring, modelling, and predicting the recruitment to multi-centre clinical trials. The work is motivated by overly optimistic and narrow prediction intervals produced by existing time-homogeneous…

统计方法学 · 统计学 2020-09-03 Szymon Urbas , Chris Sherlock , Paul Metcalfe

In this paper, we introduce the increasing belief criterion in association rule mining. The criterion uses a recursive application of Bayes' theorem to compute a rule's belief. Extracted rules are required to have their belief increase with…

人工智能 · 计算机科学 2020-01-15 Luis Ignacio Lopera González , Adrian Derungs , Oliver Amft

The collective risk model (CRM) for frequency and severity is an important tool for retail insurance ratemaking, macro-level catastrophic risk forecasting, as well as operational risk in banking regulation. This model, which is initially…

应用统计 · 统计学 2021-10-20 Jae Youn Ahn , Himchan Jeong , Yang Lu

Bayesian inference paradigms are regarded as powerful tools for solution of inverse problems. However, when applied to inverse problems in physical sciences, Bayesian formulations suffer from a number of inconsistencies that are often…

统计方法学 · 统计学 2024-11-21 Klaus Mosegaard

Multivariate meta-analysis (MMA) is a powerful tool for jointly estimating multiple outcomes' treatment effects. However, the validity of results from MMA is potentially compromised by outcome reporting bias (ORB), or the tendency for…

应用统计 · 统计学 2021-10-19 Ray Bai , Xiaokang Liu , Lifeng Lin , Yulun Liu , Stephen E. Kimmel , Haitao Chu , Yong Chen

Many medical decision-making tasks can be framed as partially observed Markov decision processes (POMDPs). However, prevailing two-stage approaches that first learn a POMDP and then solve it often fail because the model that best fits the…

机器学习 · 统计学 2020-04-01 Joseph Futoma , Michael C. Hughes , Finale Doshi-Velez

We present a general method for fitting finite mixture models (FMM). Learning in a mixture model consists of finding the most likely cluster assignment for each data-point, as well as finding the parameters of the clusters themselves. In…

机器学习 · 统计学 2019-12-20 Mathias Edman , Neil Dhir

Clustering is a crucial task in various domains of knowledge, including medicine, epidemiology, genomics, environmental science, economics, and visual sciences, among others. Methodologies for inferring the number of clusters have often…

统计方法学 · 统计学 2025-05-26 Clara Grazian

Accurate modeling of bacterial biofilm growth is essential for understanding their complex dynamics in biomedical, environmental, and industrial settings. These dynamics are shaped by a variety of environmental influences, including the…

计算工程、金融与科学 · 计算机科学 2025-12-18 Lukas Fritsch , Hendrik Geisler , Jan Grashorn , Felix Klempt , Meisam Soleimani , Matteo Broggi , Philipp Junker , Michael Beer

Historical data about disease outcomes can be integrated into the analysis of clinical trials in many ways. We build on existing literature that uses prognostic scores from a predictive model to increase the efficiency of treatment effect…

统计方法学 · 统计学 2020-12-25 David Walsh , Alejandro Schuler , Diana Hall , Jon Walsh , Charles Fisher

Paired cluster-randomized experiments (pCRTs) are common across many disciplines because there is often natural clustering of individuals, and paired randomization can help balance baseline covariates to improve experimental precision.…

统计方法学 · 统计学 2024-07-03 Charlotte Z. Mann , Adam C. Sales , Johann A. Gagnon-Bartsch

Insurance products frequently cover significant claims arising from a variety of sources. To model losses from these products accurately, actuarial models must account for high-severity claims. A widely used strategy is to apply a mixture…

统计方法学 · 统计学 2025-04-30 Sébastien Jessup , Mélina Mailhot , Mathieu Pigeon

Concept Bottleneck Model (CBM) is a methods for explaining neural networks. In CBM, concepts which correspond to reasons of outputs are inserted in the last intermediate layer as observed values. It is expected that we can interpret the…

机器学习 · 统计学 2024-03-15 Naoki Hayashi , Yoshihide Sawada

Evidence accumulation models (EAMs) are an important class of cognitive models used to analyze both response time and response choice data recorded from decision-making tasks. Developments in estimation procedures have helped EAMs become…

统计方法学 · 统计学 2023-06-01 Viet Hung Dao , David Gunawan , Robert Kohn , Minh-Ngoc Tran , Guy E. Hawkins , Scott D. Brown

Bayesian Optimisation has gained much popularity lately, as a global optimisation technique for functions that are expensive to evaluate or unknown a priori. While classical BO focuses on where to gather an observation next, it does not…

机器人学 · 计算机科学 2017-03-14 Philippe Morere , Roman Marchant , Fabio Ramos

The ensemble average of physical properties of molecules is closely related to the distribution of molecular conformations, and sampling such distributions is a fundamental challenge in physics and chemistry. Traditional methods like…

机器学习 · 计算机科学 2025-08-06 Liya Guo , Zun Wang , Chang Liu , Junzhe Li , Pipi Hu , Yi Zhu

Modern medical research demands specialized causal inference methods evaluating complex continuous-time dynamic treatment regimens using observational data. For instance, obtaining the causal effects of intravenous administration, a…

统计方法学 · 统计学 2026-04-02 Haiyan Zhu , Yingchun Zhou

Matching is a widely used causal inference design that aims to approximate a randomized experiment using observational data by forming matched sets of treated and control units based on similarities in their covariates. Ideally, treated…

统计方法学 · 统计学 2026-04-06 Jianan Zhu , Jeffrey Zhang , Zijian Guo , Siyu Heng

Randomized clinical trials are considered the gold standard for estimating causal effects. Nevertheless, in studies that are aimed at examining adverse effects of interventions, such trials are often impractical because of ethical and…

统计方法学 · 统计学 2020-01-20 Anthony D. Scotina , Andrew R. Zullo , Robert J. Smith , Roee Gutman

Robust decision making involves making decisions in the presence of uncertainty and is often used in critical domains such as healthcare, supply chains, and finance. Causality plays a crucial role in decision-making as it predicts the…

统计方法学 · 统计学 2025-07-23 Saideep Nannapaneni , Joseph Sakaya , Kyle Caron , Pedro HM Albuquerque , Zaid Tashman