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Mendelian randomization is an instrumental variable method that utilizes genetic information to investigate the causal effect of a modifiable exposure on an outcome. In most cases, the exposure changes over time. Understanding the…

统计方法学 · 统计学 2024-03-11 Haodong Tian , Ashish Patel , Stephen Burgess

Variational inference is a general approach for approximating complex density functions, such as those arising in latent variable models, popular in machine learning. It has been applied to approximate the maximum likelihood estimator and…

统计方法学 · 统计学 2018-04-19 Yen-Chi Chen , Y. Samuel Wang , Elena A. Erosheva

Unpacking and comprehending how black-box machine learning algorithms make decisions has been a persistent challenge for researchers and end-users. Explaining time-series predictive models is useful for clinical applications with high…

机器学习 · 计算机科学 2023-05-09 Amin Nayebi , Sindhu Tipirneni , Chandan K Reddy , Brandon Foreman , Vignesh Subbian

This study investigates the impact of masking strategies on time series imputation models in healthcare settings. While current approaches predominantly rely on random masking for model evaluation, this practice fails to capture the…

机器学习 · 计算机科学 2025-02-05 Linglong Qian , Yiyuan Yang , Wenjie Du , Jun Wang , Richard Dobsoni , Zina Ibrahim

We present a sample path dependent measure of causal influence between two time series. The proposed measure is a random variable whose expected sum is the directed information. A realization of the proposed measure may be used to identify…

信息论 · 计算机科学 2018-10-15 Gabriel Schamberg , Todd P. Coleman

Parametric statistical methods play a central role in analyzing risk through its underlying frequency and severity components. Given the wide availability of numerical algorithms and high-speed computers, researchers and practitioners often…

应用统计 · 统计学 2025-06-17 Michael R. Powers , Jiaxin Xu

The SHAP (short for Shapley additive explanation) framework has become an essential tool for attributing importance to variables in predictive tasks. In model-agnostic settings, SHAP uses the concept of Shapley values from cooperative game…

机器学习 · 统计学 2026-02-12 Justin Whitehouse , Ayush Sawarni , Vasilis Syrgkanis

Exposure measurement error is a ubiquitous but often overlooked challenge in causal inference with observational data. Existing methods accounting for exposure measurement error largely rely on restrictive parametric assumptions, while…

统计方法学 · 统计学 2025-06-27 Keith Barnatchez , Rachel Nethery , Bryan E. Shepherd , Giovanni Parmigiani , Kevin P. Josey

Variational inference is a popular method for estimating model parameters and conditional distributions in hierarchical and mixed models, which arise frequently in many settings in the health, social, and biological sciences. Variational…

统计方法学 · 统计学 2019-01-10 Ted Westling , Tyler H. McCormick

Variable selection naturally arises as a useful subject when faced with data with massive predictor space. In addition to the massive dimensionality, the data may be characterized by intra-subject correlation, and cure fraction, which are…

统计方法学 · 统计学 2025-12-24 Richard Tawiah , Shu Kay Ng , Geoffrey J. McLachlan

How can we explain the predictions of a machine learning model? When the data is structured as a multivariate time series, this question induces additional difficulties such as the necessity for the explanation to embody the time dependency…

机器学习 · 计算机科学 2021-06-11 Jonathan Crabbé , Mihaela van der Schaar

Clinical prediction models are estimated using a sample of limited size from the target population, leading to uncertainty in predictions, even when the model is correctly specified. Generally, not all patient profiles are observed…

统计方法学 · 统计学 2024-02-09 Doranne Thomassen , Saskia le Cessie , Hans van Houwelingen , Ewout Steyerberg

Information from frequency bands in biomedical time series provides useful summaries of the observed signal. Many existing methods consider summaries of the time series obtained over a few well-known, pre-defined frequency bands of…

统计方法学 · 统计学 2023-01-11 Raanju R. Sundararajan , Scott A. Bruce

Dynamic factor models are often estimated by point-estimation methods, disregarding parameter uncertainty. We propose a method accounting for parameter uncertainty by means of posterior approximation, using variational inference. Our…

统计方法学 · 统计学 2022-10-14 Erik Spånberg

The use of observational time series data to assess the impact of multi-time point interventions is becoming increasingly common as more health and activity data are collected and digitized via wearables, social media, and electronic health…

统计方法学 · 统计学 2020-12-01 Roy Adams , Suchi Saria , Michael Rosenblum

We propose a causal hidden Markov model to achieve robust prediction of irreversible disease at an early stage, which is safety-critical and vital for medical treatment in early stages. Specifically, we introduce the hidden variables which…

计算机视觉与模式识别 · 计算机科学 2021-03-31 Jing Li , Botong Wu , Xinwei Sun , Yizhou Wang

In some causal inference scenarios, the treatment variable is measured inaccurately, for instance in epidemiology or econometrics. Failure to correct for the effect of this measurement error can lead to biased causal effect estimates.…

机器学习 · 计算机科学 2024-09-13 Antti Pöllänen , Pekka Marttinen

Researchers in explainable artificial intelligence have developed numerous methods for helping users understand the predictions of complex supervised learning models. By contrast, explaining the $\textit{uncertainty}$ of model outputs has…

机器学习 · 统计学 2023-11-01 David S. Watson , Joshua O'Hara , Niek Tax , Richard Mudd , Ido Guy

Estimation of a treatment effect by a regression discontinuity design faces a severe challenge when the running variable contains measurement errors since the errors smoothen the discontinuity on which the identification depends. The…

统计方法学 · 统计学 2019-09-24 Kota Mori

One of the most popular methods of the machine learning prediction explanation is the SHapley Additive exPlanations method (SHAP). An imprecise SHAP as a modification of the original SHAP is proposed for cases when the class probability…

机器学习 · 计算机科学 2021-06-18 Lev V. Utkin , Andrei V. Konstantinov , Kirill A. Vishniakov
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