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We consider performing simulation experiments in the presence of covariates. Here, covariates refer to some input information other than system designs to the simulation model that can also affect the system performance. To make decisions,…

统计方法学 · 统计学 2022-11-28 Cheng Li , Siyang Gao , Jianzhong Du

In 2023, the U.S. Food and Drug Administration issued guidance for adjustment of covariates in randomized clinical trials, emphasizing its role in enhancing precision and power through prognostic baseline variables. Despite its potential,…

统计方法学 · 统计学 2026-05-28 Kelly Van Lancker , Iván Díaz , Stijn Vansteelandt

Quantifying the heterogeneity of treatment effect is important for understanding how a commercial product or medical treatment affects different population subgroups. While much of treatment effect heterogeneity analysis focuses on the…

统计方法学 · 统计学 2026-03-03 Haodong Li , Alan E Hubbard , Oliver J Hines , Andrea M Storås , Kajsa Kvist , Mark van der Laan

Many machine learning approaches for decision making, such as reinforcement learning, rely on simulators or predictive models to forecast the time-evolution of quantities of interest, e.g., the state of an agent or the reward of a policy.…

机器学习 · 计算机科学 2024-01-17 Petar Bevanda , Max Beier , Armin Lederer , Stefan Sosnowski , Eyke Hüllermeier , Sandra Hirche

Balancing influential covariates is crucial for valid treatment comparisons in clinical studies. While covariate-adaptive randomization is commonly used to achieve balance, its performance can be inadequate when the number of baseline…

统计方法学 · 统计学 2024-12-30 Ziqing Guo , Yang Liu , Lucy Xia

Importance sampling is often used in machine learning when training and testing data come from different distributions. In this paper we propose a new variant of importance sampling that can reduce the variance of importance sampling-based…

机器学习 · 计算机科学 2016-11-11 Philip S. Thomas , Emma Brunskill

When investigators seek to estimate causal effects, they often assume that selection into treatment is based only on observed covariates. Under this identification strategy, analysts must adjust for observed confounders. While basic…

应用统计 · 统计学 2019-01-09 Luke Keele , Dylan Small

Improving efficiency of importance sampler is at the center of research in Monte Carlo methods. While adaptive approach is usually difficult within the Markov Chain Monte Carlo framework, the counterpart in importance sampling can be…

统计方法学 · 统计学 2007-12-11 Heng Lian

Prediction of time-to-event data often suffers from rare event rates, small sample sizes, high dimensionality and low signal-to-noise ratios. Incorporating published prediction models from large-scale studies is expected to improve the…

统计方法学 · 统计学 2022-08-01 Di Wang , Wen Ye , Randall Sung , Hui Jiang , Jeremy M. G. Taylor , Lisa Ly , Kevin He

In recent years, the black-box nature of deep learning models has limited their application in high-stakes domains such as medical diagnosis and finance, where interpretability is essential. To address this, we propose a novel approach…

计算与语言 · 计算机科学 2026-05-26 Yike Sun , Mingkun Xu , Mu You , Zhongzhi He , Henghua Shen , Zehan Tan , Derek F. Wong , Tao Fang

We consider the problem of using expert data with unobserved confounders for imitation and reinforcement learning. We begin by defining the problem of learning from confounded expert data in a contextual MDP setup. We analyze the…

机器学习 · 计算机科学 2021-10-14 Guy Tennenholtz , Assaf Hallak , Gal Dalal , Shie Mannor , Gal Chechik , Uri Shalit

When estimating target parameters in nonparametric models with nuisance parameters, substituting the unknown nuisances with nonparametric estimators can introduce ``plug-in bias.'' Traditional methods addressing this suboptimal…

统计方法学 · 统计学 2024-06-04 Brian Cho , Yaroslav Mukhin , Kyra Gan , Ivana Malenica

We study the covariate shift problem in the context of nonparametric regression over a reproducing kernel Hilbert space (RKHS). We focus on two natural families of covariate shift problems defined using the likelihood ratios between the…

统计理论 · 数学 2023-06-07 Cong Ma , Reese Pathak , Martin J. Wainwright

Unbiased assessment of the predictivity of models learnt by supervised machine-learning methods requires knowledge of the learned function over a reserved test set (not used by the learning algorithm). The quality of the assessment depends,…

统计理论 · 数学 2022-07-11 Elias Fekhari , Bertrand Iooss , Joseph Muré , Luc Pronzato , Maria-João Rendas

Transfer learning, or domain adaptation, is concerned with machine learning problems in which training and testing data come from possibly different distributions (denoted as $\mu$ and $\mu'$, respectively). In this work, we give an…

机器学习 · 计算机科学 2020-05-20 Xuetong Wu , Jonathan H. Manton , Uwe Aickelin , Jingge Zhu

We present methods for estimating loss-based measures of the performance of a prediction model in a target population that differs from the source population in which the model was developed, in settings where outcome and covariate data are…

统计方法学 · 统计学 2022-10-06 Samantha Morrison , Constantine Gatsonis , Issa J. Dahabreh , Bing Li , Jon A. Steingrimsson

Over the past decades, researchers and ML practitioners have come up with better and better ways to build, understand and improve the quality of ML models, but mostly under the key assumption that the training data is distributed…

机器学习 · 计算机科学 2019-10-14 Yeounoh Chung , Peter J. Haas , Eli Upfal , Tim Kraska

Previous studies have shown that hazard ratios between treatment groups estimated with the Cox model are uninterpretable because the unspecified baseline hazard of the model fails to identify temporal change in the risk set composition due…

机器学习 · 统计学 2025-09-04 Takashi Hayakawa , Satoshi Asai

We study estimation of a class prior for unlabeled target samples which possibly differs from that of source population. Moreover, it is assumed that the source data is partially observable: only samples from the positive class and from the…

机器学习 · 统计学 2026-05-22 Jan Mielniczuk , Wojciech Rejchel , Paweł Teisseyre

Predicting risks of chronic diseases has become increasingly important in clinical practice. When a prediction model is developed in a given source cohort, there is often a great interest to apply the model to other cohorts. However, due to…

统计方法学 · 统计学 2020-03-05 Zheng Jiayin , Zheng Yingye , Hsu Li