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This paper explores the application of spiking neural networks (SNNs), known for their low-power binary spikes, to bearing fault diagnosis, bridging the gap between high-performance AI algorithms and real-world industrial scenarios. In…

神经与进化计算 · 计算机科学 2025-06-17 Lin Zuo , Yongqi Ding , Mengmeng Jing , Kunshan Yang , Biao Chen , Yunqian Yu

RNA design, the task of finding a sequence that folds into a target secondary structure, has broad biological and biomedical impact but remains computationally challenging due to the exponentially large sequence space and exponentially many…

机器学习 · 计算机科学 2026-02-16 Milan Gautam , Ning Dai , Tianshuo Zhou , Bowen Xie , David Mathews , Liang Huang

Solving the RNA inverse folding problem is a critical prerequisite to RNA design, an emerging field in bioengineering with a broad range of applications from reaction catalysis to cancer therapy. Although significant progress has been made…

定量方法 · 定量生物学 2019-03-07 Jade Shi , Rhiju Das , Vijay S. Pande

In biomedical applications of machine learning, relevant information often has a rich structure that is not easily encoded as real-valued predictors. Examples of such data include DNA or RNA sequences, gene sets or pathways, gene…

基因组学 · 定量生物学 2019-10-16 Jake Crawford , Casey S. Greene

Automatic Speech Recognition (ASR) has increased in popularity in recent years. The evolution of processor and storage technologies has enabled more advanced ASR mechanisms, fueling the development of virtual assistants such as Amazon…

音频与语音处理 · 电气工程与系统科学 2024-12-04 Sebastian Baunsgaard , Sebastian B. Wrede , Pınar Tozun

Machine learning (ML) has revolutionized medical prognostics by integrating advanced algorithms with clinical data to enhance disease prediction, risk assessment, and patient outcome forecasting. This comprehensive review critically…

机器学习 · 计算机科学 2024-08-06 Michael Fascia

Recent advances and achievements of artificial intelligence (AI) as well as deep and graph learning models have established their usefulness in biomedical applications, especially in drug-drug interactions (DDIs). DDIs refer to a change in…

In response to the COVID-19 pandemic, the integration of interpretable machine learning techniques has garnered significant attention, offering transparent and understandable insights crucial for informed clinical decision making. This…

机器学习 · 计算机科学 2024-09-10 Jinzhi Shen , Ke Ma

Scientific research faces high costs and inefficiencies with traditional methods, but the rise of deep learning and large language models (LLMs) offers innovative solutions. This survey reviews transformer-based LLM applications across…

机器学习 · 计算机科学 2025-09-16 Kaiyuan Tian , Linbo Qiao , Baihui Liu , Gongqingjian Jiang , Shanshan Li , Dongsheng Li

While the exponential growth of the space sector and new operative concepts ask for higher spacecraft autonomy, the development of AI-assisted space systems was so far hindered by the low availability of power and energy typical of space…

神经与进化计算 · 计算机科学 2025-12-15 Paolo Lunghi , Stefano Silvestrini , Dominik Dold , Gabriele Meoni , Alexander Hadjiivanov , Dario Izzo

With the rapid global spread of COVID-19, more and more data related to this virus is becoming available, including genomic sequence data. The total number of genomic sequences that are publicly available on platforms such as GISAID is…

基因组学 · 定量生物学 2021-11-16 Sarwan Ali , Murray Patterson

Model-driven analysis of biophysical phenomena is gaining increased attention and utility for medical imaging applications. In magnetic resonance imaging (MRI), the availability of well-established models for describing the relations…

医学物理 · 物理学 2023-10-31 Dinor Nagar , Nikita Vladimirov , Christian T. Farrar , Or Perlman

This study investigated the performance, explainability, and robustness of deployed artificial intelligence (AI) models in predicting mortality during the COVID-19 pandemic and beyond. The first study of its kind, we found that Bayesian…

机器学习 · 计算机科学 2023-11-30 Jacob R. Epifano , Stephen Glass , Ravi P. Ramachandran , Sharad Patel , Aaron J. Masino , Ghulam Rasool

Spiking Neural Networks (SNNs) as Machine Learning (ML) models have recently received a lot of attention as a potentially more energy-efficient alternative to conventional Artificial Neural Networks. The non-differentiability and sparsity…

机器学习 · 计算机科学 2025-12-05 Maximilian Gollwitzer , Felix Dietrich

Rising costs in recent years of developing new drugs and treatments have led to extensive research in optimization techniques in biomolecular design. Currently, the most widely used approach in biomolecular design is directed evolution,…

机器学习 · 计算机科学 2021-11-09 Alexander Whatley , Zhekun Luo , Xiangru Tang

The rise of single-cell sequencing technologies has revolutionized the exploration of drug resistance, revealing the crucial role of cellular heterogeneity in advancing precision medicine. By building computational models from existing…

基因组学 · 定量生物学 2025-02-05 Yu-An Huang , Xiyue Cao , Zhu-Hong You , Yue-Chao Li , Xuequn Shang , Zhi-An Huang

Gene expression can be used to subtype breast cancer with improved prediction of risk of recurrence and treatment responsiveness over that obtained using routine immunohistochemistry (IHC). However, in the clinic, molecular profiling is…

计算机视觉与模式识别 · 计算机科学 2023-05-09 Raktim Kumar Mondol , Ewan K. A. Millar , Peter H Graham , Lois Browne , Arcot Sowmya , Erik Meijering

Researchers worldwide are seeking to repurpose existing drugs or discover new drugs to counter the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A promising source of candidates for such studies is…

计算与语言 · 计算机科学 2021-01-13 Zhi Hong , J. Gregory Pauloski , Logan Ward , Kyle Chard , Ben Blaiszik , Ian Foster

A plethora of prediction models of SARS-CoV-2 pandemic were proposed in the past. Prediction performances not only depend on the structure and features of the model, but also on its parametrization. Official databases are often biased due…

种群与进化 · 定量生物学 2021-09-27 Yuri Kheifetz , Holger Kirsten , Markus Scholz

The drug design process currently requires considerable time and resources to develop each new compound that enters the market. This work develops an application of hybrid quantum generative models based on the integration of parametrized…