相关论文: Iron role paradox in nerve degeneration and regene…
Accumulating evidence has shown that iron is involved in the mechanism underlying many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Abnormal (higher) iron accumulation has been…
The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively…
Degeneration and adaptation are two competing sides of the same coin called resilience in the progressive processes of brain aging or diseases. Degeneration accumulates during brain aging and other cerebral activities, causing structural…
Elevated kurtosis values have been observed in subcortical grey matter structures of patients with neurodegenerative diseases. Here we tested whether these elevated values are related to iron content, which generate magnetic fields that add…
Several works reported increased differentiation of neuronal cells grown on graphene; however, the molecular mechanism driving axon elongation on this material has remained elusive. Here, we study the axonal transport of nerve growth factor…
Dehydration and brain interstitial fluid alterations associate to cognitive dysfunction. We now explore whether changes in matrix hydration are a possible common signal for modulation of water-transfer rates and neuron function.
We compare aging in a disordered ferromagnet and in a spin glass, by studying the different phases of a reentrant system. We have measured the relaxation of the low-frequency ac susceptibility, in both the ferromagnetic and spin-glass…
We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this…
Neurodegenerative diseases are characterized by the accumulation of misfolded proteins and widespread disruptions in brain function. Computational modeling has advanced our understanding of these processes, but efforts have traditionally…
The loss of melanized neurons in the substantia nigra pars compacta is a primary feature in Parkinson's disease (PD). Iron deposition occurs in conjunction with this loss. Loss of nigral neurons should remove barriers for diffusion and…
This study investigates how weight decay affects the update behavior of individual neurons in deep neural networks through a combination of applied analysis and experimentation. Weight decay can cause the expected magnitude and angular…
Diabetic neuropathy is a disorder characterized by impaired nerve function and reduction of the number of epidermal nerve fibers per epidermal surface. Additionally, as neuropathy related nerve fiber loss and regrowth progresses over time,…
Developing effective therapies against epilepsy remains a challenge. The complex and multifaceted nature of this disease still fuels controversies about its origin. In this perspective article, we argue that conflicting hypotheses can be…
To accomplish a task, the brain works like a synchronized neuronal network where all the involved neurons work together. When a lesion spreads in the brain, depending on its evolution, it can reach a significant portion of relevant area. As…
We have studied the slow dynamics of the ferromagnetic phases of the re-entrant CdCr_{2x}In_{2-2x}S_4 system for 0.85<x<=1 by means of low frequency ac susceptibility and magnetization measurements. Experimental procedures widely used in…
We investigate how emergent nematic order and nematic fluctuations affect several macroscopic properties of both the normal and superconducting states of the iron pnictides. Due to its magnetic origin, long-range nematic order enhances…
Free radicals play a key role in the ageing process. The strongly debated free radical theory of ageing even states that damage caused by free radicals is the main cause of aging on a cellular level. However, free radicals are small,…
Neurodegenerative diseases, such as Alzheimer's or Parkinson's disease, show characteristic degradation of structural brain networks. This degradation eventually leads to changes in the network dynamics and degradation of cognitive…
Training neural networks with batch normalization and weight decay has become a common practice in recent years. In this work, we show that their combined use may result in a surprising periodic behavior of optimization dynamics: the…
Pathologically altered iron levels, detected using iron-sensitive MRI techniques such as quantitative susceptibility mapping (QSM), are observed in neurological disorders such as multiple sclerosis (MS) and may play a crucial role in…