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Multiple sequence alignment (MSA) data play a crucial role in the study of protein mutations, with contact prediction being a notable application. Existing methods are often model-based or algorithmic and typically do not incorporate…

统计方法学 · 统计学 2026-01-23 Fan Yang , Zhao Ren , Wen Zhou , Kejue Jia , Robert Jernigan

Networks play a prominent role in the study of complex systems of interacting entities in biology, sociology, and economics. Despite this diversity, we demonstrate here that a statistical model decomposing networks into matching and…

物理与社会 · 物理学 2016-02-05 Rudolf P. Rohr , Russel E. Naisbit , Christian Mazza , Louix-Félix Bersier

Motivation: RNA design aims to find RNA sequences that fold into a given target secondary structure, a problem also known as RNA inverse folding. However, not all target structures are designable. Recent advances in RNA designability have…

数据结构与算法 · 计算机科学 2026-04-28 Tianshuo Zhou , David H. Mathews , Liang Huang

The increasing amounts of semantic resources offer valuable storage of human knowledge; however, the probability of wrong entries increases with the increased size. The development of approaches that identify potentially spurious parts of a…

机器学习 · 计算机科学 2021-11-24 Sebastian Mežnar , Matej Bevec , Nada Lavrač , Blaž Škrlj

This chapter provides a comprehensive and self-contained discussion of the most recent developments of information theory of networks. Maximum entropy models of networks are the least biased ensembles enforcing a set of constraints and are…

无序系统与神经网络 · 物理学 2022-06-14 Ginestra Bianconi

Multiple sets of measurements on the same objects obtained from different platforms may reflect partially complementary information of the studied system. The integrative analysis of such data sets not only provides us with the opportunity…

统计方法学 · 统计学 2020-10-15 Yipeng Song , Johan A. Westerhuis , Age K. Smilde

The web of data consists of data published on the web in such a way that they can be interpreted and connected together. It is thus critical to establish links between these data, both for the web of data and for the semantic web that it…

人工智能 · 计算机科学 2011-07-25 François Scharffe , Jérôme Euzenat

Sequence set is a widely-used type of data source in a large variety of fields. A typical example is protein structure prediction, which takes an multiple sequence alignment (MSA) as input and aims to infer structural information from it.…

生物大分子 · 定量生物学 2019-06-27 Fusong Ju , Jianwei Zhu , Guozheng Wei , Qi Zhang , Shiwei Sun , Dongbo Bu

Anomaly detection on attributed networks aims to find the nodes whose behaviors are significantly different from other majority nodes. Generally, network data contains information about relationships between entities, and the anomaly is…

社会与信息网络 · 计算机科学 2024-01-09 Enbo He , Yitong Hao , Yue Zhang , Guisheng Yin , Lina Yao

Multiple sequence alignment (MSA) has been one of the most important problems in bioinformatics for more decades and it is still heavily examined by many mathematicians and biologists. However, mostly because of the practical motivation of…

定量方法 · 定量生物学 2015-11-17 Kristóf Takács

Evolutionary modeling applications are the best way to provide full information to support in-depth understanding of evaluation of organisms. These applications mainly depend on identifying the evolutionary history of existing organisms and…

计算工程、金融与科学 · 计算机科学 2018-06-01 Sara Shehab , Sameh Abdulah , Arabi E. Keshk

Network data are commonly collected in a variety of applications, representing either directly measured or statistically inferred connections between features of interest. In an increasing number of domains, these networks are collected…

机器学习 · 统计学 2022-09-05 Michael Weylandt , George Michailidis

We present Multi-Scale Manifold Alignment(MSMA), an information-geometric framework that decomposes LLM representations into local, intermediate, and global manifolds and learns cross-scale mappings that preserve geometry and information.…

计算与语言 · 计算机科学 2025-10-14 Yukun Zhang , Qi Dong

The alignment of biological networks has the potential to teach us as much about biology and disease as has sequence alignment. Sequence alignment can be optimally solved in polynomial time. In contrast, network alignment is $NP$-hard,…

分子网络 · 定量生物学 2016-07-12 Nil Mamano , Wayne Hayes

Symbolic data analysis (SDA) is an emerging area of statistics concerned with understanding and modelling data that takes distributional form (i.e. symbols), such as random lists, intervals and histograms. It was developed under the premise…

统计计算 · 统计学 2020-04-09 Boris Beranger , Huan Lin , Scott A. Sisson

Unified representation learning for multi-source data integration faces two important challenges: blockwise missingness and blockwise signal heterogeneity. The former arises from sources observing different, yet potentially overlapping,…

统计方法学 · 统计学 2026-02-13 Ziqi Liu , Ye Tian , Weijing Tang

We propose a generalized stochastic block model to explore the mesoscopic structures in signed networks by grouping vertices that exhibit similar positive and negative connection profiles into the same cluster. In this model, the group…

社会与信息网络 · 计算机科学 2015-06-17 Jonathan Q. Jiang

Networks offer a powerful approach to modeling complex systems by representing the underlying set of pairwise interactions. Link prediction is the task that predicts links of a network that are not directly visible, with profound…

物理与社会 · 物理学 2024-04-22 Yijun Ran , Xiao-Ke Xu , Tao Jia

Many data sets contain rich information about objects, as well as pairwise relations between them. For instance, in networks of websites, scientific papers, and other documents, each node has content consisting of a collection of words, as…

机器学习 · 计算机科学 2014-10-30 Yaojia Zhu , Xiaoran Yan , Lise Getoor , Cristopher Moore

Sequence alignment supports numerous tasks in bioinformatics, natural language processing, pattern recognition, social sciences, and others fields. While the alignment of two sequences may be performed swiftly in many applications, the…

数据结构与算法 · 计算机科学 2021-12-06 Eloi Araujo , Luiz Rozante , Diego P. Rubert , Fabio V. Martinez
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