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Adaptive sample size re-estimation (SSR) is a well-established strategy for improving the efficiency and flexibility of clinical trials. Its central challenge is determining whether, and by how much, to increase the sample size at an…

统计方法学 · 统计学 2025-10-20 Rui Jin , Cai Wu , Qiqi Deng

Adapting models pre-trained on large-scale datasets is a proven way to reach strong performance quickly for down-stream tasks. However, the growth of state-of-the-art mod-els makes traditional full fine-tuning unsuitable and difficult,…

计算机视觉与模式识别 · 计算机科学 2026-03-24 Maxime Fontana , Michael Spratling , Miaojing Shi

Large observational datasets, including those derived from electronic health records, are a valuable resource for medical research but are often affected by missingness, measurement error, and misclassification. Two-phase sampling with…

统计方法学 · 统计学 2026-03-23 Jasper B. Yang , Bryan E. Shepherd , Thomas Lumley , Pamela A. Shaw

Background With microarray technology becoming mature and popular, the selection and use of a small number of relevant genes for accurate classification of samples is a hot topic in the circles of biostatistics and bioinformatics. However,…

统计方法学 · 统计学 2014-03-05 Suyan Tian , Mayte Suárez-Fariñas

The dynamics of molecules are governed by rare event transitions between long-lived (metastable) states. To explore these transitions efficiently, many enhanced sampling protocols have been introduced that involve using simulations with…

化学物理 · 物理学 2022-09-30 Maaike M. Galama , Hao Wu , Andreas Krämer , Mohsen Sadeghi , Frank Noé

Modern randomization methods in clinical trials are invariably adaptive, meaning that the assignment of the next subject to a treatment group uses the accumulated information in the trial. Some of the recent adaptive randomization methods…

统计方法学 · 统计学 2024-02-12 Alan R. Vazquez , Weng Kee Wong

Adaptive algorithms belong to an important class of algorithms used in radar target detection to overcome prior uncertainty of interference covariance. The contamination of the empirical covariance matrix by the useful signal leads to…

信号处理 · 电气工程与系统科学 2021-01-01 Boris N. Oreshkin

Multi-armed bandits are widely used for sequential experimentation in clinical trials, recommendation systems, and online platforms. While regret minimization and valid inference from adaptively collected data have each been studied…

统计方法学 · 统计学 2026-04-28 Yu-Shiou Willy Lin , Dae Woong Ham , Iavor Bojinov

Classical randomized experiments, equipped with randomization-based inference, provide assumption-free inference for treatment effects. They have been the gold standard for drawing causal inference and provide excellent internal validity.…

统计方法学 · 统计学 2021-09-22 Zihao Yang , Tianyi Qu , Xinran Li

Precision medicine is an emerging field that takes into account individual heterogeneity to inform better clinical practice. In clinical trials, the evaluation of treatment effect heterogeneity is an important component, and recently, many…

统计方法学 · 统计学 2023-02-24 Yuejia Xu , Angela M. Wood , Brian D. M. Tom

We present a novel spectral learning algorithm for simultaneous localization and mapping (SLAM) from range data with known correspondences. This algorithm is an instance of a general spectral system identification framework, from which it…

机器学习 · 计算机科学 2012-07-12 Byron Boots , Geoffrey J. Gordon

Next-generation networks utilize the Open Radio Access Network (O-RAN) architecture to enable dynamic resource management, facilitated by the RAN Intelligent Controller (RIC). While deep reinforcement learning (DRL) models show promise in…

人工智能 · 计算机科学 2025-11-20 Fatemeh Lotfi , Hossein Rajoli , Fatemeh Afghah

Dynamic treatment regimes (DTRs) are sequences of decision rules to guide treatment assignments in response to a patient's evolving, time-varying disease status. Sequential multiple assignment randomized trials (SMARTs) are considered the…

统计方法学 · 统计学 2026-04-29 Xinru Wang , Meghna Bose , Bibhas Chakraborty , Robert Mahar

Estimation and inference for the Average Treatment Effect (ATE) is a cornerstone of causal inference and often serves as the foundation for developing procedures for more complicated settings. Although traditionally analyzed in a batch…

机器学习 · 统计学 2025-02-10 Ojash Neopane , Aaditya Ramdas , Aarti Singh

Adaptive Random Testing (ART) has faced criticism, particularly for its computational inefficiency, as highlighted by Arcuri and Briand. Their analysis clarified how ART requires a quadratic number of distance computations as the number of…

软件工程 · 计算机科学 2025-02-25 Matteo Biagiola , Robert Feldt , Paolo Tonella

Multi-agent reinforcement learning (MARL) is a powerful paradigm for solving cooperative and competitive decision-making problems. While many MARL benchmarks have been proposed, few combine continuous state and action spaces with…

人工智能 · 计算机科学 2025-11-18 Artem Pshenitsyn , Aleksandr Panov , Alexey Skrynnik

Speculative Decoding is a prominent technique for accelerating the autoregressive inference of large language models (LLMs) by employing a fast draft model to propose candidate token sequences and a large target model to verify them in…

计算与语言 · 计算机科学 2025-12-18 Chendong Sun , Ali Mao , Lei Xu , mingmin Chen

The adaptive rejection sampling (ARS) algorithm is a universal random generator for drawing samples efficiently from a univariate log-concave target probability density function (pdf). ARS generates independent samples from the target via…

统计计算 · 统计学 2017-10-10 L. Martino , F. Louzada

The recent surge of building software systems powered by Large Language Models (LLMs) has led to the development of various testing frameworks, primarily focused on treating prompt templates as the unit of testing. Despite the significant…

软件工程 · 计算机科学 2025-01-24 Juyeon Yoon , Robert Feldt , Shin Yoo

Rerandomization is an experimental design technique that repeatedly randomizes treatment assignments until covariates are balanced between treatment groups. Rerandomization in the design stage of an experiment can lead to many asymptotic…

统计方法学 · 统计学 2026-04-10 Antônio Carlos Herling Ribeiro Junior