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Epidemiological evidence supports an association between exposure to air pollution during pregnancy and birth and child health outcomes. Typically, such associations are estimated by regressing an outcome on daily or weekly measures of…

Epidemiological research supports an association between maternal exposure to air pollution during pregnancy and adverse children's health outcomes. Advances in exposure assessment and statistics allow for estimation of both critical…

Exposure to environmental pollutants during the gestational period can significantly impact infant health outcomes, such as birth weight and neurological development. Identifying critical windows of susceptibility, which are specific…

应用统计 · 统计学 2024-08-19 Yisen Jin , Aaron J. Molstad , Ander Wilson , Joseph Antonelli

Children's health studies support an association between maternal environmental exposures and children's birth outcomes. A common goal is to identify critical windows of susceptibility--periods during gestation with increased association…

统计方法学 · 统计学 2023-11-10 Daniel Mork , Marianthi-Anna Kioumourtzoglou , Marc Weisskopf , Brent A Coull , Ander Wilson

Exposures to environmental chemicals during gestation can alter health status later in life. Most studies of maternal exposure to chemicals during pregnancy have focused on a single chemical exposure observed at high temporal resolution.…

In studies of maternal exposure to air pollution a children's health outcome is regressed on exposures observed during pregnancy. The distributed lag nonlinear model (DLNM) is a statistical method commonly implemented to estimate an…

统计方法学 · 统计学 2021-06-16 Daniel Mork , Ander Wilson

Distributed lag models are useful in environmental epidemiology as they allow the user to investigate critical windows of exposure, defined as the time period during which exposure to a pollutant adversely affects health outcomes. Recent…

统计方法学 · 统计学 2021-08-02 Joseph Antonelli , Ander Wilson , Brent Coull

Quantifying associations between short-term exposure to ambient air pollution and health outcomes is an important public health priority. Many studies have investigated the association considering delayed effects within the past few days.…

统计方法学 · 统计学 2025-05-22 Tianyi Pan , Hwashin Hyun Shin , Glen McGee , Alex Stringer

This study quantifies the association between air pollution and mortality in Ontario, Canada. Exposure-response relationships in air pollution epidemiology are complex due to three features: time-lagged associations, non-linear…

统计方法学 · 统计学 2026-04-27 Tianyi Pan , Hwashin Hyun Shin , Alex Stringer , Glen McGee

Environmental exposures, such as air pollution and extreme temperatures, have complex effects on human health. These effects are often characterized by non-linear exposure-lag-response relationships and delayed impacts over time. Accurately…

统计方法学 · 统计学 2025-12-02 Álvaro Briz-Redón , Ana Corberán-Vallet , Adina Iftimi , Carmen Íñiguez

The relationship between short-term exposure to air pollution and mortality or morbidity has been the subject of much recent research, in which the standard method of analysis uses Poisson linear or additive models. In this paper we use a…

应用统计 · 统计学 2012-01-27 Duncan Lee , Gavin Shaddick

When examining the relationship between an exposure and an outcome, there is often a time lag between exposure and the observed effect on the outcome. A common statistical approach for estimating the relationship between the outcome and…

统计方法学 · 统计学 2025-04-28 Seongwon Im , Ander Wilson , Daniel Mork

Distributed Lag Models (DLMs) and similar regression approaches such as MIDAS have been used for many decades in econometrics and more recently to investigate how poor air quality adversely affects human health. In this paper we describe…

统计方法学 · 统计学 2025-01-30 Daniel Dempsey , Jason Wyse

Maternal exposure to environmental chemicals during pregnancy can alter birth and children's health outcomes. Research seeks to identify critical windows, time periods when the exposures can change future health outcomes, and estimate the…

统计方法学 · 统计学 2022-04-14 Daniel Mork , Ander Wilson

In environmental health research there is often interest in the effect of an exposure on a health outcome assessed on the same day and several subsequent days or lags. Distributed lag nonlinear models (DLNM) are a well-established…

统计方法学 · 统计学 2023-10-05 Daniel Mork , Ander Wilson

We present a statistical modelling framework for implementing Distributed Lag Models (DLMs), encompassing several extensions of the approach to capture the temporally distributed effect from covariates via regression. We place DLMs in the…

Fine particulate matter (PM2.5) measured at a given location is a mix of pollution generated locally and pollution traveling long distances in the atmosphere. Therefore, the identification of spatial scales associated with health effects…

统计方法学 · 统计学 2016-09-19 Joseph Antonelli , Joel Schwartz , Itai Kloog , Brent Coull

Distributed lag models (DLMs) express the cumulative and delayed dependence between pairs of time-indexed response and explanatory variables. In practical application, users of DLMs examine the estimated influence of a series of lagged…

应用统计 · 统计学 2018-01-23 Alastair Rushworth

Humans are exposed to complex mixtures of environmental pollutants rather than single chemicals, necessitating methods to quantify the health effects of such mixtures. Research on environmental mixtures provides insights into realistic…

统计方法学 · 统计学 2026-04-09 Aaron Sonabend , Jiangshan Zhang , Edgar Castro , Joel Schwartz , Brent A. Coull , Junwei Lu

One way to quantify exposure to air pollution and its constituents in epidemiologic studies is to use an individual's nearest monitor. This strategy results in potential inaccuracy in the actual personal exposure, introducing bias in…

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