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The ability to computationally generate novel yet physically foldable protein structures could lead to new biological discoveries and new treatments targeting yet incurable diseases. Despite recent advances in protein structure prediction,…

生物大分子 · 定量生物学 2022-11-28 Kevin E. Wu , Kevin K. Yang , Rianne van den Berg , James Y. Zou , Alex X. Lu , Ava P. Amini

Deep generative models have garnered significant attention in low-level vision tasks due to their generative capabilities. Among them, diffusion model-based solutions, characterized by a forward diffusion process and a reverse denoising…

计算机视觉与模式识别 · 计算机科学 2025-02-26 Chunming He , Yuqi Shen , Chengyu Fang , Fengyang Xiao , Longxiang Tang , Yulun Zhang , Wangmeng Zuo , Zhenhua Guo , Xiu Li

We present Prompt Diffusion, a framework for enabling in-context learning in diffusion-based generative models. Given a pair of task-specific example images, such as depth from/to image and scribble from/to image, and a text guidance, our…

计算机视觉与模式识别 · 计算机科学 2023-10-20 Zhendong Wang , Yifan Jiang , Yadong Lu , Yelong Shen , Pengcheng He , Weizhu Chen , Zhangyang Wang , Mingyuan Zhou

Diffusion models are gaining widespread use in cutting-edge image, video, and audio generation. Score-based diffusion models stand out among these methods, necessitating the estimation of score function of the input data distribution. In…

机器学习 · 计算机科学 2024-05-24 Fangzhao Zhang , Mert Pilanci

Diffusion models are increasingly used as powerful conditional generators, yet real deployments often involve multiple target distributions arising from different tasks, e.g., diverse prompt domains in text-to-image generation, or multiple…

机器学习 · 计算机科学 2026-05-26 Ziheng Cheng , Yixiao Huang , Hanlin Zhu , Haoran Geng , Somayeh Sojoudi , Jitendra Malik , Pieter Abbeel , Xin Guo

Deep stochastic processes have recently become a central paradigm for image enhancement, with many methods explicitly conditioning the stochastic trajectory on the degraded input. However, the relationship between these conditional…

计算机视觉与模式识别 · 计算机科学 2026-05-05 Wojciech Kozłowski , Radosław Kuczbański , Kamil Adamczewski , Karol Szczypkowski , Maciej Zięba

Diffusion probabilistic models have made their way into a number of high-profile applications since their inception. In particular, there has been a wave of research into using diffusion models in the prediction and design of biomolecular…

生物大分子 · 定量生物学 2024-06-05 Trevor Norton , Debswapna Bhattacharya

Spatial profiling technologies in biology, such as imaging mass cytometry (IMC) and spatial transcriptomics (ST), generate high-dimensional, multi-channel data with strong spatial alignment and complex inter-channel relationships.…

机器学习 · 计算机科学 2025-07-08 Haoran Zhang , Mingyuan Zhou , Wesley Tansey

In this paper, we argue that iterative computation with diffusion models offers a powerful paradigm for not only generation but also visual perception tasks. We unify tasks such as depth estimation, optical flow, and amodal segmentation…

计算机视觉与模式识别 · 计算机科学 2024-11-19 Rahul Ravishankar , Zeeshan Patel , Jathushan Rajasegaran , Jitendra Malik

Stable diffusion models represent the state-of-the-art in data synthesis across diverse domains and hold transformative potential for applications in science and engineering, e.g., by facilitating the discovery of novel solutions and…

机器学习 · 计算机科学 2025-10-23 Stefano Zampini , Jacob K. Christopher , Luca Oneto , Davide Anguita , Ferdinando Fioretto

Denoising diffusion models have proven to be a flexible and effective paradigm for generative modelling. Their recent extension to infinite dimensional Euclidean spaces has allowed for the modelling of stochastic processes. However, many…

Diffusion models have demonstrated impressive capabilities in synthesizing diverse content. However, despite their high-quality outputs, these models often perpetuate social biases, including those related to gender and race. These biases…

计算机视觉与模式识别 · 计算机科学 2025-03-27 Yingdong Shi , Changming Li , Yifan Wang , Yongxiang Zhao , Anqi Pang , Sibei Yang , Jingyi Yu , Kan Ren

Diffusion models (DMs) are a type of generative model that has a huge impact on image synthesis and beyond. They achieve state-of-the-art generation results in various generative tasks. A great diversity of conditioning inputs, such as text…

机器学习 · 计算机科学 2024-02-02 Weiguo Lu , Xuan Wu , Deng Ding , Jinqiao Duan , Jirong Zhuang , Gangnan Yuan

Inverse protein folding is challenging due to its inherent one-to-many mapping characteristic, where numerous possible amino acid sequences can fold into a single, identical protein backbone. This task involves not only identifying viable…

定量方法 · 定量生物学 2023-11-08 Kai Yi , Bingxin Zhou , Yiqing Shen , Pietro Liò , Yu Guang Wang

Denoising Diffusion Probabilistic Models (DDPMs) have recently achieved remarkable results in conditional and unconditional image generation. The pre-trained models can be adapted without further training to different downstream tasks, by…

计算机视觉与模式识别 · 计算机科学 2023-09-19 Asya Grechka , Guillaume Couairon , Matthieu Cord

Practically, training diffusion models typically requires explicit time conditioning to guide the network through the denoising sampling process. Especially in deterministic methods like DDIM, the absence of time conditioning leads to…

机器学习 · 计算机科学 2026-04-29 Liuzhuozheng Li , Zhiyuan Zhan , Shuhong Liu , Dengyang Jiang , Zanyi Wang , Guang Dai , Jingdong Wang , Mengmeng Wang

While conditional diffusion models have achieved remarkable success in various applications, they require abundant data to train from scratch, which is often infeasible in practice. To address this issue, transfer learning has emerged as an…

机器学习 · 计算机科学 2025-10-28 Ziheng Cheng , Tianyu Xie , Shiyue Zhang , Cheng Zhang

Searching new molecules in areas like drug discovery often starts from the core structures of candidate molecules to optimize the properties of interest. The way as such has called for a strategy of designing molecules retaining a…

机器学习 · 计算机科学 2020-09-03 Jaechang Lim , Sang-Yeon Hwang , Seungsu Kim , Seokhyun Moon , Woo Youn Kim

Data availability remains a critical bottleneck in many deep learning applications. Large-scale datasets are often expensive to collect, curate and annotate, which can limit the scalability and applicability of supervised learning methods.…

计算机视觉与模式识别 · 计算机科学 2026-05-28 Nithesh Chandher Karthikeyan , Jonas Unger , Gabriel Eilertsen

Diffusion model, the state-of-the-art generative machine learning architecture, has shown promising results airfoil inverse designs. In this study, we implemented and trained a series of diffusion models on three different airfoil geometry…

流体动力学 · 物理学 2026-01-26 Yingfan Geng , Jinhong Wang , Teng Cao