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Regression calibration as developed by Rosner, Spiegelman and Willet is used to correct the bias in effect estimates due to measurement error in continuous exposures. The method involves two models: a measurement error model (MEM) relating…

统计方法学 · 统计学 2026-02-24 Wenze Tang , Donna Spiegelman , Xiaomei Liao , Molin Wang

Measurement error arises through a variety of mechanisms. A rich literature exists on the bias introduced by covariate measurement error and on methods of analysis to address this bias. By comparison, less attention has been given to errors…

统计方法学 · 统计学 2018-11-27 Pamela Shaw , Jiwei He , Bryan Shepherd

Regression calibration is a popular approach for correcting biases in estimated regression parameters when exposure variables are measured with error. This approach involves building a calibration equation to estimate the value of the…

In epidemiology, obtaining accurate individual exposure measurements can be costly and challenging. Thus, these measurements are often subject to error. Regression calibration with a validation study is widely employed as a study design and…

统计方法学 · 统计学 2026-02-24 Zexiang Li , Donna Spiegelman , Molin Wang , Zuoheng Wang , Xin Zhou

Medical studies that depend on electronic health records (EHR) data are often subject to measurement error, as the data are not collected to support research questions under study. These data errors, if not accounted for in study analyses,…

统计方法学 · 统计学 2020-03-10 Eric J. Oh , Bryan E. Shepherd , Thomas Lumley , Pamela A. Shaw

In nutritional and environmental epidemiology, exposures are impractical to measure accurately, while practical measures for these exposures are often subject to substantial measurement error. Regression calibration is among the most used…

统计方法学 · 统计学 2026-01-27 Zexiang Li , Donna Spiegelman , Molin Wang , Zuoheng Wang , Xin Zhou

Bayesian approaches for handling covariate measurement error are well established, and yet arguably are still relatively little used by researchers. For some this is likely due to unfamiliarity or disagreement with the Bayesian inferential…

统计方法学 · 统计学 2017-08-01 Jonathan W. Bartlett , Ruth H. Keogh

The association between multidimensional exposure patterns and outcomes is commonly investigated by first applying cluster analysis algorithms to derive patterns and then estimating the associations. However, errors in the underlying…

统计方法学 · 统计学 2023-05-31 Timm Intemann , Iris Pigeot

In safety-critical applications data-driven models must not only be accurate but also provide reliable uncertainty estimates. This property, commonly referred to as calibration, is essential for risk-aware decision-making. In regression a…

机器学习 · 计算机科学 2026-04-23 Jelke Wibbeke , Nico Schönfisch , Sebastian Rohjans , Andreas Rauh

The Cox regression model is a popular model for analyzing the relationship between a covariate and a survival endpoint. The standard Cox model assumes a constant covariate effect across the entire covariate domain. However, in many…

应用统计 · 统计学 2019-09-02 Sarit Agami , David M. Zucker , Donna Spiegelman

For many cancer sites low-dose risks are not known and must be extrapolated from those observed in groups exposed at much higher levels of dose. Measurement error can substantially alter the dose-response shape and hence the extrapolated…

定量方法 · 定量生物学 2024-03-15 Mark P Little , Nobuyuki Hamada , Lydia B Zablotska

Exposure measurement error is a ubiquitous but often overlooked challenge in causal inference with observational data. Existing methods accounting for exposure measurement error largely rely on restrictive parametric assumptions, while…

统计方法学 · 统计学 2025-06-27 Keith Barnatchez , Rachel Nethery , Bryan E. Shepherd , Giovanni Parmigiani , Kevin P. Josey

When exposure measurement error (EME), confounder measurement error (CME), or both are present, health effect estimates regarding exposure mixtures and critical exposure time-window may not represent the true effects. For example, in air…

统计理论 · 数学 2025-05-28 Honghyok Kim

Propensity scores are commonly used to estimate treatment effects from observational data. We argue that the probabilistic output of a learned propensity score model should be calibrated -- i.e., a predictive treatment probability of 90%…

统计方法学 · 统计学 2024-06-06 Shachi Deshpande , Volodymyr Kuleshov

This article focuses on measurement error in covariates in regression analyses in which the aim is to estimate the association between one or more covariates and an outcome, adjusting for confounding. Error in covariate measurements, if…

统计方法学 · 统计学 2019-10-16 Ruth H. Keogh , Jonathan W. Bartlett

The objective of this work is to propose an asymptotic correction method for the estimators of parameters from regression models with covariates subject to classification errors. A correction was developed based on the least squares…

统计方法学 · 统计学 2025-07-11 Alexandre Garcia Dias , Mariana Rodrigues Motta , Alexandre Hild Aono

Measurement error in a covariate or the outcome of regression models is common, but is often ignored, even though measurement error can lead to substantial bias in the estimated covariate-outcome association. While several texts on…

统计方法学 · 统计学 2021-02-10 Linda Nab , Maarten van Smeden , Ruth H. Keogh , Rolf H. H. Groenwold

Numerous studies have examined the associations between long-term exposure to fine particulate matter (PM2.5) and adverse health outcomes. Recently, many of these studies have begun to employ high-resolution predicted PM2.5 concentrations,…

统计方法学 · 统计学 2022-11-29 Kevin P. Josey , Priyanka deSouza , Xiao Wu , Danielle Braun , Rachel Nethery

In observational causal inference, domain knowledge often leaves multiple covariate adjustments plausible, yet which sets satisfy ignorability is untestable. Different adjustment sets can yield conflicting estimates of the average treatment…

统计方法学 · 统计学 2026-03-23 Aditya Ghosh , Dominik Rothenhäusler

Propensity score methods are widely used for estimating treatment effects from observational studies. A popular approach is to estimate propensity scores by maximum likelihood based on logistic regression, and then apply inverse probability…

统计方法学 · 统计学 2017-10-24 Zhiqiang Tan
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