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In digital pathology, cell detection and classification are often prerequisites to quantify cell abundance and explore tissue spatial heterogeneity. However, these tasks are particularly challenging for multiplex immunohistochemistry (mIHC)…

图像与视频处理 · 电气工程与系统科学 2019-08-05 Yeman Brhane Hagos , Priya Lakshmi Narayanan , Ayse U. Akarca , Teresa Marafioti , Yinyin Yuan

Knowing a biomolecule's structure is inherently linked to and a prerequisite for any detailed understanding of its function. Significant effort has gone into developing technologies for structural characterization. These technologies do not…

数据结构与算法 · 计算机科学 2017-06-22 Michael Wegner , Oskar Taubert , Alexander Schug , Henning Meyerhenke

Survival analysis, as a challenging task, requires integrating Whole Slide Images (WSIs) and genomic data for comprehensive decision-making. There are two main challenges in this task: significant heterogeneity and complex inter- and…

图像与视频处理 · 电气工程与系统科学 2024-06-17 Conghao Xiong , Hao Chen , Hao Zheng , Dong Wei , Yefeng Zheng , Joseph J. Y. Sung , Irwin King

Composed Image Retrieval (CIR) retrieves target images using a multi-modal query that combines a reference image with text describing desired modifications. The primary challenge is effectively fusing this visual and textual information.…

计算机视觉与模式识别 · 计算机科学 2025-04-16 Chaoyang Wang , Zeyu Zhang , Long Teng , Zijun Li , Shichao Kan

Dataset distillation reduces the storage and computational consumption of training a network by generating a small surrogate dataset that encapsulates rich information of the original large-scale one. However, previous distillation methods…

计算机视觉与模式识别 · 计算机科学 2024-03-26 Jianyang Gu , Saeed Vahidian , Vyacheslav Kungurtsev , Haonan Wang , Wei Jiang , Yang You , Yiran Chen

Coupling a multi-capillary column (MCC) with an ion mobility (IM) spectrometer (IMS) opened a multitude of new application areas for gas analysis, especially in a medical context, as volatile organic compounds (VOCs) in exhaled breath can…

其他计算机科学 · 计算机科学 2014-05-22 Dominik Kopczynski , Sven Rahmann

Definition bias is a negative phenomenon that can mislead models. Definition bias in information extraction appears not only across datasets from different domains but also within datasets sharing the same domain. We identify two types of…

计算与语言 · 计算机科学 2024-03-26 Wenhao Huang , Qianyu He , Zhixu Li , Jiaqing Liang , Yanghua Xiao

Incomplete propagation data significantly hinders robust fake news detection. Recent approaches leverage large language models to simulate missing user interactions via role-playing, thereby enriching propagation with synthetic signals.…

计算与语言 · 计算机科学 2026-05-05 Mengyang Chen , Lingwei Wei , Wei Zhou , Songlin Hu

This philosophical paper proposes a modified version of the scientific method, in which large databases are used instead of experimental observations as the necessary empirical ingredient. This change in the source of the empirical data…

计算机视觉与模式识别 · 计算机科学 2010-05-31 Daniel Burfoot

Multiresolution analysis and matrix factorization are foundational tools in computer vision. In this work, we study the interface between these two distinct topics and obtain techniques to uncover hierarchical block structure in symmetric…

计算机视觉与模式识别 · 计算机科学 2017-05-17 Vamsi K. Ithapu , Risi Kondor , Sterling C. Johnson , Vikas Singh

Delineating anatomical regions is a key task in medical image analysis. Manual segmentation achieves high accuracy but is labor-intensive and prone to variability, thus prompting the development of automated approaches. Recently, a breadth…

图像与视频处理 · 电气工程与系统科学 2025-11-05 Alix de Langlais , Benjamin Billot , Théo Aguilar Vidal , Marc-Olivier Gauci , Hervé Delingette

Multi-view representation learning aims to capture comprehensive information from multiple views of a shared context. Recent works intuitively apply contrastive learning to different views in a pairwise manner, which is still scalable:…

计算机视觉与模式识别 · 计算机科学 2023-08-24 Jiangmeng Li , Hang Gao , Wenwen Qiang , Changwen Zheng

The development of molecular signatures for the prediction of time-to-event outcomes is a methodologically challenging task in bioinformatics and biostatistics. Although there are numerous approaches for the derivation of marker…

应用统计 · 统计学 2014-01-09 Andreas Mayr , Matthias Schmid

In this paper we introduce the SCoRe (Submodular Combinatorial Representation Learning) framework, a novel approach in representation learning that addresses inter-class bias and intra-class variance. SCoRe provides a new combinatorial…

机器学习 · 计算机科学 2024-06-07 Anay Majee , Suraj Kothawade , Krishnateja Killamsetty , Rishabh Iyer

The information bottleneck principle provides an information-theoretic method for representation learning, by training an encoder to retain all information which is relevant for predicting the label while minimizing the amount of other,…

机器学习 · 计算机科学 2020-02-19 Marco Federici , Anjan Dutta , Patrick Forré , Nate Kushman , Zeynep Akata

Modern life largely transmits genetic information from mother to daughter through the duplication of single physically intact molecules that encode information. However, copying an extended molecule requires complex copying machinery and…

种群与进化 · 定量生物学 2025-09-25 Martin J. Falk , Leon Zhou , Yoshiya J. Matsubara , Kabir Husain , Jack W. Szostak , Arvind Murugan

The efficacy of mathematical models heavily depends on the quality of the training data, yet collecting sufficient data is often expensive and challenging. Many modeling applications require inferring parameters only as a means to predict…

High-performance catalysts are crucial for sustainable energy conversion and human health. However, the discovery of catalysts faces challenges due to the absence of efficient approaches to navigating vast and high-dimensional structure and…

机器学习 · 计算机科学 2025-11-13 Jie Chen , Pengfei Ou , Yuxin Chang , Hengrui Zhang , Xiao-Yan Li , Edward H. Sargent , Wei Chen

Estimating an individual's potential response to interventions from observational data is of high practical relevance for many domains, such as healthcare, public policy or economics. In this setting, it is often the case that combinations…

机器学习 · 计算机科学 2021-03-23 Sonali Parbhoo , Stefan Bauer , Patrick Schwab

In order to define the process of restrosynthesis of a new organic molecule, it is often necessary to be able to draw inspiration from that of a molecule similar to the target one of which we know such a process. To compute such a…

数据结构与算法 · 计算机科学 2018-07-13 Stéfi Nouleho , Dominique Barth , Franck Quessette , Marc-Antoine Weisser , Dimitri Watel , Olivier David
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