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The identification of latent mediator variables is typically conducted using standard structural equation models (SEMs). When SEM is applied to mediation analysis with a causal interpretation, valid inference relies on the strong assumption…

统计方法学 · 统计学 2025-10-02 Sofia Morelli , Roberto Faleh , Holger Brandt

Summary statistics of genome-wide association studies (GWAS) teach causal relationship between millions of genetic markers and tens and thousands of phenotypes. However, underlying biological mechanisms are yet to be elucidated. We can…

机器学习 · 统计学 2019-01-25 Yongjin Park , Abhishek Sarkar , Khoi Nguyen , Manolis Kellis

Structural equation models (SEMs) are fundamental to causal mediation pathway discovery. However, traditional SEM approaches often rely on \emph{ad hoc} model specifications when handling complex data structures such as mixed data types or…

统计方法学 · 统计学 2025-10-22 Canyi Chen , Ritoban Kundu , Wei Hao , Peter X. -K. Song

Structural-equations models (SEMs) are perhaps the most commonly used framework for modeling causality. However, as we show, naively extending this framework to infinitely many variables, which is necessary, for example, to model dynamical…

人工智能 · 计算机科学 2021-12-20 Spencer Peters , Joseph Y. Halpern

Social network interference induces complex dependencies where a unit's outcome is influenced not only by its own exposure and mediator but also by those of connected neighbors. In such settings, a significant challenge lies in…

统计方法学 · 统计学 2026-03-03 Ritoban Kundu , Peter X. K. Song

The causal inference literature has increasingly recognized that explicitly targeting treatment effect heterogeneity can lead to improved scientific understanding and policy recommendations. Towards the same ends, studying the causal…

统计方法学 · 统计学 2023-03-06 Angela Ting , Antonio R. Linero

Causal mediation analysis usually requires strong assumptions, such as ignorability of the mediator, which may not hold in many social and scientific studies. Motivated by a multilevel randomized treatment experiment using functional…

应用统计 · 统计学 2017-07-11 Yi Zhao , Xi Luo

Mediation analysis has traditionally focused on outcome-level summary contrasts, such as mean effects, which may obscure substantial distributional changes induced by complex and nonlinear causal mechanisms. We propose Distributional Causal…

机器学习 · 统计学 2026-05-05 Jinlun Zhang , Haoneng Huang , Zishu Zhan , Chunquan Ou

Motivated by an analysis of causal mechanism from economic stress to entrepreneurial withdrawals through depressed affect, we develop a two-layer generalized varying coefficient mediation model. This model captures the bridging effects of…

统计理论 · 数学 2022-12-06 Jingyuan Liu , Yujie Liao , Runze Li

This study introduces a mediation analysis framework when the mediator is a graph. A Gaussian covariance graph model is assumed for graph representation. Causal estimands and assumptions are discussed under this representation. With a…

统计方法学 · 统计学 2023-07-11 Yixi Xu , Yi Zhao

We consider structural equation models (SEMs), in which every variable is a function of a subset of the other variables and a stochastic error. Each such SEM is naturally associated with a directed graph describing the relationships between…

组合数学 · 数学 2023-08-04 Mathias Drton , Benjamin Hollering , Jun Wu

The ability to conduct interventions plays a pivotal role in learning causal relationships among variables, thus facilitating applications across diverse scientific disciplines such as genomics, economics, and machine learning. However, in…

机器学习 · 统计学 2024-11-04 Abhinav Kumar , Kirankumar Shiragur , Caroline Uhler

Accounting for the complexity of psychological theories requires methods that can predict not only changes in the means of latent variables -- such as personality factors, creativity, or intelligence -- but also changes in their variances.…

统计方法学 · 统计学 2025-05-27 Luna Fazio , Paul-Christian Bürkner

Environmental health studies are increasingly measuring endogenous omics data ($\boldsymbol{M}$) to study intermediary biological pathways by which an exogenous exposure ($\boldsymbol{A}$) affects a health outcome ($\boldsymbol{Y}$), given…

Conditional correlation networks, within Gaussian Graphical Models (GGM), are widely used to describe the direct interactions between the components of a random vector. In the case of an unlabelled Heterogeneous population, Expectation…

统计理论 · 数学 2022-03-09 Thomas Lartigue , Stanley Durrleman , Stéphanie Allassonnière

High-dimensional mediation analysis aims to identify mediating pathways and to estimate indirect effects linking an exposure to an outcome. In this paper, we propose a Bayesian framework to address key challenges in these analyses,…

统计方法学 · 统计学 2026-02-13 Youngho Bae , Chanmin Kim , Fenglei Wang , Qi Sun , Kyu Ha Lee

We introduce the Graph Mixture Density Networks, a new family of machine learning models that can fit multimodal output distributions conditioned on graphs of arbitrary topology. By combining ideas from mixture models and graph…

机器学习 · 计算机科学 2021-06-28 Federico Errica , Davide Bacciu , Alessio Micheli

Graphical causal models are an important tool for knowledge discovery because they can represent both the causal relations between variables and the multivariate probability distributions over the data. Once learned, causal graphs can be…

人工智能 · 计算机科学 2017-04-11 Andrew J Sedgewick , Joseph D. Ramsey , Peter Spirtes , Clark Glymour , Panayiotis V. Benos

This paper provides a tutorial discussion on path analysis structure with concept of structural equation modelling (SEM). The paper delivers an introduction to path analysis technique and explain to how to deal with analyzing the data with…

统计方法学 · 统计学 2015-04-15 Hashem Salarzadeh Jenatabadi

Mediation analysis is concerned with the decomposition of the total effect of an exposure on an outcome into the indirect effect through a given mediator, and the remaining direct effect. This is ideally done using longitudinal measurements…

统计理论 · 数学 2019-12-04 Murthy N Mittinty , Stijn Vansteelandt
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