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Circular dichroism spectroscopy is an essential technique for understanding molecular structure and magnetic materials, but spatial resolution is limited by the wavelength of light, and sensitivity sufficient for single-molecule…

Resonant radiofrequency cavities enable exquisite time-energy control of electron beams when synchronized with laser driven photoemission. We present a lossless monochromator design that exploits this fine control in the…

加速器物理 · 物理学 2021-01-07 Cameron J. R. Duncan , David A. Muller , Jared M. Maxson

Programmable electron-beam scanning offers new opportunities to improve dose efficiency and suppress scan-induced artifacts in scanning transmission electron microscopy. Here, we systematically benchmark the impact of non-raster…

Monochromators are an essential component in electron microscopy and spectroscopy for enhancing the spatial and energy resolution. However, its adoption in scanning electron microscopes remains limited because of its high cost and…

仪器与探测器 · 物理学 2025-10-27 M. J. Adriaans , J. P. Hoogenboom , A. Mohammadi-Gheidari

Large-scale neural recording with high spatio-temporal resolution is essential for understanding information processing in brain, yet current neural interfaces fall far short of comprehensively capturing brain activity due to extremely high…

The extended Ptychographical Iterative Engine (ePIE) is a widely used phase retrieval algorithm for Electron Ptychography from 4-dimensional (4-D) Scanning Transmission Electron Microscopy (4-D STEM) measurements acquired with a focused or…

Coherent low-energy electrons have been demonstrated as a practical tool for imaging individual macromolecules and two-dimensional (2D) crystals. Low-energy electrons exhibit unique properties: low radiation damage to biological molecules…

仪器与探测器 · 物理学 2025-09-29 Tatiana Latychevskaia

The ability to use coherent light for material science and applications is directly linked to our ability to measure short optical pulses. While free-space optical methods are well-established, achieving this on a chip would offer the…

Monitoring of electrocardiogram (ECG) provides vital information as well as any cardiovascular anomalies. Recent advances in the technology of wearable electronics have enabled compact devices to acquire personal physiological signals in…

信号处理 · 电气工程与系统科学 2022-07-26 Sadaf Sarafan , Hoang Vuong , Daniel Jilani , Samir Malhotra , Michael P. H. Lau , Manoj Vishwanath , Tadesse Ghirmai , Hung Cao

Dynamic full-field optical coherence tomography (D-FFOCT) has recently emerged as a label-free imaging tool, capable of resolving cell types and organelles within 3D live samples, whilst monitoring their activity at tens of milliseconds…

Label-free optical microscopy through absorption or scattering spectroscopy provides fundamental insights across biology and materials science, yet its sensitivity remains fundamentally limited by photon shot noise. While recent…

An optical microscope is probably the most intuitive, simple and commonly used instrument to observe objects and discuss behaviors through images. Although the idea of imaging electrochemical processes operando by optical microscopy was…

光学 · 物理学 2022-11-16 Jean-François Lemineur , Hui Wang , Wei Wang , Frédéric Kanoufi

Optical phase measurement is critical for many applications and traditional approaches often suffer from mechanical instability, temporal latency, and computational complexity. In this paper, we describe compact phase sensor arrays based on…

The CMOS camera found in many cellphones is sensitive to ionized electrons. Gamma rays penetrate into the phone and produce ionized electrons that are then detected by the camera. Thermal noise and other noise needs to be removed on the…

仪器与探测器 · 物理学 2014-01-07 Joshua J. Cogliati , Kurt W. Derr , Jayson Wharton

Electroluminescence (EL) imaging is a powerful and established technique for assessing the quality of photovoltaic (PV) modules, which consist of many electrically connected solar cells arranged in a grid. The analysis of imperfect…

计算机视觉与模式识别 · 计算机科学 2020-09-01 Evgenii Sovetkin , Ansgar Steland

The appearance of direct electron detectors marked a new era for electron diffraction. Their high sensitivity and low noise opens the possibility to extend electron diffraction from transmission electron microscopes (TEM) to lower energies…

应用物理 · 物理学 2025-02-18 Nikita Denisov , Andrey Orekhov , Johan Verbeeck

This work presents a quantum-limited optomechanical sensing platform for real-time detection and discrimination of chiral molecules, based on a multilayer hybrid plasmonic-mechanical resonator. Leveraging quantum zero-point motion and…

光学 · 物理学 2025-07-29 Giuseppina Simone

Analytical electron microscopy and spectroscopy of biological specimens, polymers, and other beam sensitive materials has been a challenging area due to irradiation damage. There is a pressing need to develop novel imaging and spectroscopic…

Electro-optical sampling of Terahertz fields with ultrashort pulsed probes is a well-established approach for directly measuring the electric field of THz radiation. This technique usually relies on balanced detection to record the optical…

Optical absorption measurements characterize a wide variety of systems from atomic gases to \emph{in-vivo} diagnostics of living organisms. Here we study the potential of non-classical techniques to reduce statistical noise below the…