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We develop and evaluate tolerance interval methods for dynamic treatment regimes (DTRs) that can provide more detailed prognostic information to patients who will follow an estimated optimal regime. Although the problem of constructing…

统计方法学 · 统计学 2017-04-26 Daniel J. Lizotte , Arezoo Tahmasebi

Recent clinical trials have shown that the adaptive drug therapy can be more efficient than a standard MTD-based policy in treatment of cancer patients. The adaptive therapy paradigm is not based on a preset schedule; instead, the doses are…

定量方法 · 定量生物学 2020-08-06 Mark Gluzman , Jacob G. Scott , Alexander Vladimirsky

Adopting Convolutional Neural Networks (CNNs) in the daily routine of primary diagnosis requires not only near-perfect precision, but also a sufficient degree of generalization to data acquisition shifts and transparency. Existing CNN…

计算机视觉与模式识别 · 计算机科学 2023-06-22 Mara Graziani , Sebastian Otalora , Stephane Marchand-Maillet , Henning Muller , Vincent Andrearczyk

The inherent capabilities of a language model (LM) and the reasoning strategies it employs jointly determine its performance in reasoning tasks. While test-time scaling is regarded as an effective approach to tackling complex reasoning…

计算与语言 · 计算机科学 2025-05-27 Zhihong Pan , Kai Zhang , Yuze Zhao , Yupeng Han

Black-box heterogeneous treatment effect (HTE) models are increasingly being used to create personalized policies that assign individuals to their optimal treatments. However, they are difficult to understand, and can be burdensome to…

机器学习 · 计算机科学 2022-08-09 Han Wu , Sarah Tan , Weiwei Li , Mia Garrard , Adam Obeng , Drew Dimmery , Shaun Singh , Hanson Wang , Daniel Jiang , Eytan Bakshy

Estimating personalized effects of treatments is a complex, yet pervasive problem. To tackle it, recent developments in the machine learning (ML) literature on heterogeneous treatment effect estimation gave rise to many sophisticated, but…

机器学习 · 计算机科学 2022-06-17 Jonathan Crabbé , Alicia Curth , Ioana Bica , Mihaela van der Schaar

With dramatic improvements in optimization software, the solution of large-scale problems that seemed intractable decades ago are now a routine task. This puts even more real-world applications into the reach of optimizers. At the same…

最优化与控制 · 数学 2023-03-07 Marc Goerigk , Michael Hartisch

Reinforcement learning (RL) has the potential to significantly improve clinical decision making. However, treatment policies learned via RL from observational data are sensitive to subtle choices in study design. We highlight a simple…

机器学习 · 计算机科学 2020-12-23 Christina X. Ji , Michael Oberst , Sanjat Kanjilal , David Sontag

Machine-learning models have demonstrated great success in learning complex patterns that enable them to make predictions about unobserved data. In addition to using models for prediction, the ability to interpret what a model has learned…

机器学习 · 统计学 2019-11-15 W. James Murdoch , Chandan Singh , Karl Kumbier , Reza Abbasi-Asl , Bin Yu

To achieve the goal of providing the best possible care to each patient, physicians need to customize treatments for patients with the same diagnosis, especially when treating diseases that can progress further and require additional…

统计方法学 · 统计学 2022-10-25 Xiao Li , Brent R Logan , S M Ferdous Hossain , Erica E M Moodie

Technological advances have enabled the generation of unique and complementary types of data or views (e.g. genomics, proteomics, metabolomics) and opened up a new era in multiview learning research with the potential to lead to new…

机器学习 · 计算机科学 2024-02-19 Hengkang Wang , Han Lu , Ju Sun , Sandra E Safo

In the field of high-performance computing (HPC), there has been recent exploration into the use of deep reinforcement learning for cluster scheduling (DRL scheduling), which has demonstrated promising outcomes. However, a significant…

机器学习 · 计算机科学 2024-03-26 Boyang Li , Zhiling Lan , Michael E. Papka

Artificial intelligence-augmented technology represents a considerable opportunity for improving healthcare delivery. Significant progress has been made to demonstrate the value of complex models to enhance clinicians` efficiency in…

人机交互 · 计算机科学 2025-04-08 Mohammad Golam Kibria , Lauren Kucirka , Javed Mostafa

Although deep pre-trained language models have shown promising benefit in a large set of industrial scenarios, including Click-Through-Rate (CTR) prediction, how to integrate pre-trained language models that handle only textual signals into…

计算与语言 · 计算机科学 2023-08-23 Dong Wang , Kavé Salamatian , Yunqing Xia , Weiwei Deng , Qi Zhiang

A common concern when a policymaker draws causal inferences from and makes decisions based on observational data is that the measured covariates are insufficiently rich to account for all sources of confounding, i.e., the standard no…

统计方法学 · 统计学 2023-10-25 Tao Shen , Yifan Cui

Deep learning models in recommender systems are usually trained in the batch mode, namely iteratively trained on a fixed-size window of training data. Such batch mode training of deep learning models suffers from low training efficiency,…

信息检索 · 计算机科学 2020-09-07 Yichao Wang , Huifeng Guo , Ruiming Tang , Zhirong Liu , Xiuqiang He

We present an interpretable companion model for any pre-trained black-box classifiers. The idea is that for any input, a user can decide to either receive a prediction from the black-box model, with high accuracy but no explanations, or…

机器学习 · 统计学 2020-02-12 Danqing Pan , Tong Wang , Satoshi Hara

Interpretability is a pressing issue for machine learning. Common approaches to interpretable machine learning constrain interactions between features of the input, rendering the effects of those features on a model's output comprehensible…

机器学习 · 计算机科学 2023-05-11 Kieran A. Murphy , Dani S. Bassett

The application of rough set theory in incomplete information systems is a key problem in practice since missing values almost always occur in knowledge acquisition due to the error of data measuring, the limitation of data collection, or…

人工智能 · 计算机科学 2019-06-14 Min Shu , Wei Zhu

As an emerging interpretable technique, Generalized Additive Models (GAMs) adopt neural networks to individually learn non-linear functions for each feature, which are then combined through a linear model for final predictions. Although…

机器学习 · 计算机科学 2024-08-01 Viet Duong , Qiong Wu , Zhengyi Zhou , Hongjue Zhao , Chenxiang Luo , Eric Zavesky , Huaxiu Yao , Huajie Shao