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Observational causal inference is useful for decision making in medicine when randomized clinical trials (RCT) are infeasible or non generalizable. However, traditional approaches fail to deliver unconfounded causal conclusions in practice.…

A core challenge in survival analysis is to model the distribution of censored time-to-event data, where the event of interest may be a death, failure, or occurrence of a specific event. Previous studies have showed that ranking and maximum…

机器学习 · 计算机科学 2025-01-27 Liwen Zhang , Lianzhen Zhong , Fan Yang , Di Dong , Hui Hui , Jie Tian

A survival dataset describes a set of instances (e.g. patients) and provides, for each, either the time until an event (e.g. death), or the censoring time (e.g. when lost to follow-up - which is a lower bound on the time until the event).…

机器学习 · 计算机科学 2023-06-22 Ali Hossein Gharari Foomani , Michael Cooper , Russell Greiner , Rahul G. Krishnan

The use of instrumental variables for estimating the effect of an exposure on an outcome is popular in econometrics, and increasingly so in epidemiology. This increasing popularity may be attributed to the natural occurrence of instrumental…

统计方法学 · 统计学 2016-08-03 T. Martinussen , S. Vansteelandt , E. J. Tchetgen Tchetgen , D. M. Zucker

As in many fields of medical research, survival analysis has witnessed a growing interest in the application of deep learning techniques to model complex, high-dimensional, heterogeneous, incomplete, and censored medical data. Current…

机器学习 · 计算机科学 2023-12-25 Patricia A. Apellániz , Juan Parras , Santiago Zazo

Dynamic assessment of mortality risk in the intensive care unit (ICU) can be used to stratify patients, inform about treatment effectiveness or serve as part of an early-warning system. Static risk scoring systems, such as APACHE or SAPS,…

Machine learning has been widely used in healthcare applications to approximate complex models, for clinical diagnosis, prognosis, and treatment. As deep learning has the outstanding ability to extract information from time series, its true…

机器学习 · 计算机科学 2022-11-14 Ke Liao , Wei Wang , Armagan Elibol , Lingzhong Meng , Xu Zhao , Nak Young Chong

Mortality prediction in intensive care units is considered one of the critical steps for efficiently treating patients in serious condition. As a result, various prediction models have been developed to address this problem based on modern…

机器学习 · 计算机科学 2020-12-15 Huachuan Wang , Yuanfei Bi

Background: The predictive Intensive Care Unit (ICU) scoring system plays an important role in ICU management because it predicts important outcomes, especially mortality. Many scoring systems have been developed and used in the ICU. These…

人工智能 · 计算机科学 2023-07-18 Mingquan Lin , Song Wang , Ying Ding , Lihui Zhao , Fei Wang , Yifan Peng

Learning the dynamic causal structure of time series is a challenging problem. Most existing approaches rely on distributional or structural invariance to uncover underlying causal dynamics, assuming stationary or partially stationary…

机器学习 · 计算机科学 2026-02-27 Dezhi Yang , Qiaoyu Tan , Carlotta Domeniconi , Jun Wang , Lizhen Cui , Guoxian Yu

Background: Cardiovascular diseases (CVDs) are among the leading causes of death worldwide. Predictive scores providing personalised risk of developing CVD are increasingly used in clinical practice. Most scores, however, utilise a…

Accurate survival prediction is essential for personalised cancer treatment. We propose ModalSurv, a multimodal deep survival framework integrating clinical, MRI, histopathology, and RNA-sequencing data via modality-specific projections and…

机器学习 · 计算机科学 2025-12-19 Noorul Wahab , Ethar Alzaid , Jiaqi Lv , Fayyaz Minhas , Adam Shephard , Shan E Ahmed Raza

Intensive Care Unit Electronic Health Records (ICU EHRs) store multimodal data about patients including clinical notes, sparse and irregularly sampled physiological time series, lab results, and more. To date, most methods designed to learn…

机器学习 · 计算机科学 2021-03-22 Satya Narayan Shukla , Benjamin M. Marlin

The application of deep learning in survival analysis (SA) allows utilizing unstructured and high-dimensional data types uncommon in traditional survival methods. This allows to advance methods in fields such as digital health, predictive…

机器学习 · 计算机科学 2021-11-18 Tobias Weber , Michael Ingrisch , Bernd Bischl , David Rügamer

In critical care, intensivists are required to continuously monitor high dimensional vital signs and lab measurements to detect and diagnose acute patient conditions. This has always been a challenging task. In this study, we propose a…

机器学习 · 计算机科学 2019-01-15 Ziyuan Pan , Hao Du , Kee Yuan Ngiam , Fei Wang , Ping Shum , Mengling Feng

Deep neural networks for survival prediction outper-form classical approaches in discrimination, which is the ordering of patients according to their time-of-event. Conversely, classical approaches like the Cox Proportional Hazards model…

机器学习 · 计算机科学 2022-09-01 Patrick Fuhlert , Anne Ernst , Esther Dietrich , Fabian Westhaeusser , Karin Kloiber , Stefan Bonn

Survival analysis is a fundamental tool for modeling time-to-event data in healthcare, engineering, and finance, where censored observations pose significant challenges. While traditional methods like the Beran estimator offer nonparametric…

机器学习 · 计算机科学 2025-06-13 Andrei V. Konstantinov , Vlada A. Efremenko , Lev V. Utkin

Interpreting critical variables involved in complex biological processes related to survival time can help understand prediction from survival models, evaluate treatment efficacy, and develop new therapies for patients. Currently, the…

机器学习 · 计算机科学 2022-10-03 Xinxing Wu , Chong Peng , Richard Charnigo , Qiang Cheng

Survival analysis, which estimates the probability of event occurrence over time from censored data, is fundamental in numerous real-world applications, particularly in high-stakes domains such as healthcare and risk assessment. Despite…

机器学习 · 计算机科学 2025-05-26 Yu Liu , Weiyao Tao , Tong Xia , Simon Knight , Tingting Zhu

Over time, the performance of clinical prediction models may deteriorate due to changes in clinical management, data quality, disease risk and/or patient mix. Such prediction models must be updated in order to remain useful. Here, we…