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Synthetic lethality (SL) is a promising gene interaction for cancer therapy. Recent SL prediction methods integrate knowledge graphs (KGs) into graph neural networks (GNNs) and employ attention mechanisms to extract local subgraphs as…

机器学习 · 计算机科学 2025-03-20 Xuexin Chen , Ruichu Cai , Zhengting Huang , Zijian Li , Jie Zheng , Min Wu

Synthetic lethality (SL) is a promising concept for novel discovery of anti-cancer drug targets. However, wet-lab experiments for detecting SLs are faced with various challenges, such as high cost, low consistency across platforms or cell…

机器学习 · 计算机科学 2018-10-23 Yong Liu , Min Wu , Chenghao Liu , Xiao-Li Li , Jie Zheng

Synthetic Lethal (SL) relationships, though rare among the vast array of gene combinations, hold substantial promise for targeted cancer therapy. Despite advancements in AI model accuracy, there is still a significant need among domain…

人机交互 · 计算机科学 2024-07-23 Haoran Jiang , Shaohan Shi , Shuhao Zhang , Jie Zheng , Quan Li

Learning meaningful representations of free-hand sketches remains a challenging task given the signal sparsity and the high-level abstraction of sketches. Existing techniques have focused on exploiting either the static nature of sketches…

计算机视觉与模式识别 · 计算机科学 2021-03-26 Peng Xu , Chaitanya K. Joshi , Xavier Bresson

Sourced from multiple sensors and organized chronologically, Multivariate Time-Series (MTS) data involves crucial spatial-temporal dependencies. To capture these dependencies, Graph Neural Networks (GNNs) have emerged as powerful tools. As…

人工智能 · 计算机科学 2025-10-07 Yucheng Wang , Min Wu , Ruibing Jin , Xiaoli Li , Lihua Xie , Zhenghua Chen

Synthetic likelihood (SL) is a strategy for parameter inference when the likelihood function is analytically or computationally intractable. In SL, the likelihood function of the data is replaced by a multivariate Gaussian density over…

统计方法学 · 统计学 2022-02-21 Umberto Picchini , Umberto Simola , Jukka Corander

Theoretical works on supervised transfer learning (STL) -- where the learner has access to labeled samples from both source and target distributions -- have for the most part focused on statistical aspects of the problem, while efficient…

机器学习 · 统计学 2025-07-08 Yuyang Deng , Samory Kpotufe

Accurate prediction of synthetic lethality (SL) is important for guiding the development of cancer drugs and therapies. SL prediction faces significant challenges in the effective fusion of heterogeneous multi-source data. Existing…

Benefiting from the powerful expressive capability of graphs, graph-based approaches have achieved impressive performance in various biomedical applications. Most existing methods tend to define the adjacency matrix among samples manually…

机器学习 · 计算机科学 2021-07-02 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yao Zhao

Synthetic Data Generation (SDG), leveraging Large Language Models (LLMs), has recently been recognized and broadly adopted as an effective approach to improve the performance of smaller but more resource and compute efficient LLMs through…

机器学习 · 计算机科学 2026-03-25 Srideepika Jayaraman , Achille Fokoue , Dhaval Patel , Jayant Kalagnanam

We propose the Soft Graph Transformer (SGT), a soft-input-soft-output neural architecture designed for MIMO detection. While Maximum Likelihood (ML) detection achieves optimal accuracy, its exponential complexity makes it infeasible in…

机器学习 · 计算机科学 2026-04-14 Jiadong Hong , Lei Liu , Xinyu Bian , Wenjie Wang , Zhaoyang Zhang

Multi-graph learning is crucial for extracting meaningful signals from collections of heterogeneous graphs. However, effectively integrating information across graphs with differing topologies, scales, and semantics, often in the absence of…

机器学习 · 计算机科学 2026-02-02 Zahra Moslemi , Ziyi Liang , Norbert Fortin , Babak Shahbaba

Multi-label image recognition aims to predict a set of labels that present in an image. The key to deal with such problem is to mine the associations between image contents and labels, and further obtain the correct assignments between…

计算机视觉与模式识别 · 计算机科学 2023-04-25 Yanan Wu , Songhe Feng , Yang Wang

Link prediction is a fundamental problem in many graph based applications, such as protein-protein interaction prediction. Graph neural network (GNN) has recently been widely used for link prediction. However, existing GNN based link…

机器学习 · 计算机科学 2023-03-02 Kai-Lang Yao , Wu-Jun Li

Objectives. We generate via advanced Deep Learning (DL) techniques artificial leaf images in an automatized way. We aim to dispose of a source of training samples for AI applications for modern crop management. Such applications require…

计算机视觉与模式识别 · 计算机科学 2023-01-11 Alessandro Benfenati , Davide Bolzi , Paola Causin , Roberto Oberti

Domain generalization on graphs aims to develop models with robust generalization capabilities, ensuring effective performance on the testing set despite disparities between testing and training distributions. However, existing methods…

机器学习 · 计算机科学 2024-11-21 Qin Tian , Chen Zhao , Minglai Shao , Wenjun Wang , Yujie Lin , Dong Li

Background: Synthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e.g. by mutations, amplifications or deletions) results in cell death. In recent years, SL has emerged as an…

分子网络 · 定量生物学 2015-10-06 Sriganesh Srihari , Jitin Singla , Limsoon Wong , Mark A. Ragan

Transformers have recently emerged as powerful neural networks for graph learning, showcasing state-of-the-art performance on several graph property prediction tasks. However, these results have been limited to small-scale graphs, where the…

机器学习 · 计算机科学 2023-12-19 Vijay Prakash Dwivedi , Yozen Liu , Anh Tuan Luu , Xavier Bresson , Neil Shah , Tong Zhao

Graph Convolutional Networks (GCNs) suffer from severe performance degradation in deep architectures due to over-smoothing. While existing studies primarily attribute the over-smoothing to repeated applications of graph Laplacian operators,…

机器学习 · 计算机科学 2025-07-23 Furong Peng , Jinzhen Gao , Xuan Lu , Kang Liu , Yifan Huo , Sheng Wang

Sequence feature embedding is a challenging task due to the unstructuredness of sequence, i.e., arbitrary strings of arbitrary length. Existing methods are efficient in extracting short-term dependencies but typically suffer from…

机器学习 · 统计学 2021-10-06 Chitta Ranjan , Samaneh Ebrahimi , Kamran Paynabar
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