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A common concern when trying to draw causal inferences from observational data is that the measured covariates are insufficiently rich to account for all sources of confounding. In practice, many of the covariates may only be proxies of the…

统计方法学 · 统计学 2023-08-31 Oliver Dukes , Ilya Shpitser , Eric J. Tchetgen Tchetgen

Mediation analysis has become a widely used method for identifying the pathways through which an independent variable influences a dependent variable via intermediate mediators. However, limited research addresses the case where mediators…

统计方法学 · 统计学 2025-06-10 Rui Ren , Haoyi Yang , Qian Xiao , Lingzhou Xue , Yuan Huang

The causal inference literature has increasingly recognized that explicitly targeting treatment effect heterogeneity can lead to improved scientific understanding and policy recommendations. Towards the same ends, studying the causal…

统计方法学 · 统计学 2023-03-06 Angela Ting , Antonio R. Linero

Causal mediation analyses investigate the mechanisms through which causes exert their effects, and are therefore central to scientific progress. The literature on the non-parametric definition and identification of mediational effects in…

机器学习 · 统计学 2025-06-13 Richard Liu , Nicholas T. Williams , Kara E. Rudolph , Iván Díaz

Causal mediation analysis decomposes the total effect of a treatment on an outcome into the indirect effect, operating through the mediator, and the direct effect, operating through other pathways. One can estimate only the pure indirect…

应用统计 · 统计学 2025-07-16 Vindyani Herath , Ronald J. Bosch , Judith J. Lok

We study nonparametric estimation for the partially conditional average treatment effect, defined as the treatment effect function over an interested subset of confounders. We propose a hybrid kernel weighting estimator where the weights…

统计方法学 · 统计学 2021-03-08 Jiayi Wang , Raymond K. W. Wong , Shu Yang , Kwun Chuen Gary Chan

Large-scale datasets with count outcome variables are widely present in various applications, and the Poisson regression model is among the most popular models for handling count outcomes. This paper considers the high-dimensional sparse…

统计方法学 · 统计学 2024-10-29 Prabrisha Rakshit , Zijian Guo

We develop a Gaussian-process mixture model for heterogeneous treatment effect estimation that leverages the use of transformed outcomes. The approach we will present attempts to improve point estimation and uncertainty quantification…

统计方法学 · 统计学 2018-12-19 Abbas Zaidi , Sayan Mukherjee

The shape of the relationship between a continuous exposure variable and a binary disease variable is often central to epidemiologic investigations. This paper investigates a number of issues surrounding inference and the shape of the…

统计方法学 · 统计学 2019-02-01 Li Xing , Xuekui Zhang , Igor Burstyn , Paul Gustafson

Recent approaches to causal inference have focused on causal effects defined as contrasts between the distribution of counterfactual outcomes under hypothetical interventions on the nodes of a graphical model. In this article we develop…

统计方法学 · 统计学 2023-04-26 Iván Díaz

Growth curve analysis (GCA) has a wide range of applications in various fields where growth trajectories need to be modeled. Heteroscedasticity is often present in the error term, which can not be handled with sufficient flexibility by…

统计方法学 · 统计学 2025-03-11 Jieying Jiao , Wenling Song , Yishu Xue , Jun Yan

Causal mediation analysis is a powerful tool in environmental health research, allowing researchers to uncover the pathways through which exposures influence health outcomes. While traditional mediation methods have been widely applied to…

It is of substantial scientific interest to detect mediators that lie in the causal pathway from an exposure to a survival outcome. However, with high-dimensional mediators, as often encountered in modern genomic data settings, there is a…

统计方法学 · 统计学 2024-08-14 Tzu-Jung Huang , Zhonghua Liu , Ian W. McKeague

We consider the problem of identifying intermediate variables (or mediators) that regulate the effect of a treatment on a response variable. While there has been significant research on this classical topic, little work has been done when…

统计方法学 · 统计学 2021-07-29 Abhishek Chakrabortty , Preetam Nandy , Hongzhe Li

Causal mediation analysis provides techniques for defining and estimating effects that may be endowed with mechanistic interpretations. With many scientific investigations seeking to address mechanistic questions, causal direct and indirect…

Clinical and epidemiological studies encode participant information in multivariate vectors with mixed type variables on continuous, truncated, ordinal, and binary scales. Semiparametric Gaussian Copula (SGC) assumes that observed data is…

统计方法学 · 统计学 2026-03-19 Debangan Dey , Vadim Zipunnikov

It is often of interest to decompose a total effect of an exposure into the component that acts on the outcome through some mediator and the component that acts independently through other pathways. Said another way, we are interested in…

统计理论 · 数学 2016-01-21 Peng Ding , Tyler J. VanderWeele

Researchers are often interested in learning not only the effect of treatments on outcomes, but also the pathways through which these effects operate. A mediator is a variable that is affected by treatment and subsequently affects outcome.…

统计方法学 · 统计学 2021-12-22 Jeremiah Jones , Ashkan Ertefaie , Robert L. Strawderman

Causal mediation analysis is increasingly abundant in biology, psychology, and epidemiology studies, etc. In particular, with the advent of the big data era, the issue of high-dimensional mediators is becoming more prevalent. In…

统计方法学 · 统计学 2023-07-10 Minghao Chen , Yingchun Zhou

The presence of intermediate confounders, also called recanting witnesses, is a fundamental challenge to the investigation of causal mechanisms in mediation analysis, preventing the identification of natural path-specific effects. Proposed…

统计方法学 · 统计学 2024-01-10 Tat-Thang Vo , Nicholas Williams , Richard Liu , Kara E. Rudolph , Ivan Dıaz