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Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level, hindering the integrated consideration of…

Whole Slide Imaging (WSI) has become an important topic during the last decade. Even though significant progress in both medical image processing and computational resources has been achieved, there are still problems in WSI that need to be…

图像与视频处理 · 电气工程与系统科学 2019-03-19 Wafa Chenni , Habib Herbi , Morteza Babaie , H. R. Tizhoosh

In the realm of digital pathology, multi-magnification Multiple Instance Learning (multi-mag MIL) has proven effective in leveraging the hierarchical structure of Whole Slide Images (WSIs) to reduce information loss and redundant data.…

计算机视觉与模式识别 · 计算机科学 2024-10-11 Yujian Liu , Ruoxuan Wu , Xinjie Shen , Zihuang Lu , Lingyu Liang , Haiyu Zhou , Shipu Xu , Shaoai Cai , Shidang Xu

Whole slide images (WSIs) in computational pathology (CPath) pose a major computational challenge due to their gigapixel scale, often requiring the processing of tens to hundreds of thousands of high-resolution patches per slide. This…

计算机视觉与模式识别 · 计算机科学 2025-08-21 Yonghan Shin , SeungKyu Kim , Won-Ki Jeong

We consider machine-learning-based thyroid-malignancy prediction from cytopathology whole-slide images (WSI). Multiple instance learning (MIL) approaches, typically used for the analysis of WSIs, divide the image (bag) into patches…

In computational pathology, random sampling of patches during training of Multiple Instance Learning (MIL) methods is computationally efficient and serves as a regularization strategy. Despite its promising benefits, questions concerning…

计算机视觉与模式识别 · 计算机科学 2024-03-11 H. Keshvarikhojasteh , J. P. W. Pluim , M. Veta

Histopathological whole slide images (WSIs) classification has become a foundation task in medical microscopic imaging processing. Prevailing approaches involve learning WSIs as instance-bag representations, emphasizing significant…

计算机视觉与模式识别 · 计算机科学 2024-03-13 Jiawen Li , Yuxuan Chen , Hongbo Chu , Qiehe Sun , Tian Guan , Anjia Han , Yonghong He

It is clinically crucial and potentially very beneficial to be able to analyze and model directly the spatial distributions of cells in histopathology whole slide images (WSI). However, most existing WSI datasets lack cell-level…

Deep learning methods are widely applied in digital pathology to address clinical challenges such as prognosis and diagnosis. As one of the most recent applications, deep models have also been used to extract molecular features from whole…

图像与视频处理 · 电气工程与系统科学 2022-03-29 Amir Safarpoor , Jason D. Hipp , H. R. Tizhoosh

Whole slide image (WSI) classification has emerged as a powerful tool in computational pathology, but remains constrained by domain shifts, e.g., due to different organs, diseases, or institution-specific variations. To address this…

计算机视觉与模式识别 · 计算机科学 2025-05-14 Pratibha Kumari , Daniel Reisenbüchler , Afshin Bozorgpour , Nadine S. Schaadt , Friedrich Feuerhake , Dorit Merhof

While Multiple Instance Learning (MIL) has shown promising results in digital Pathology Whole Slide Image (WSI) classification, such a paradigm still faces performance and generalization problems due to challenges in high computational…

计算机视觉与模式识别 · 计算机科学 2023-03-16 Honglin Li , Chenglu Zhu , Yunlong Zhang , Yuxuan Sun , Zhongyi Shui , Wenwei Kuang , Sunyi Zheng , Lin Yang

Deploying digital pathology models across medical centers is challenging due to distribution shifts. Recent advances in domain generalization improve model transferability in terms of aggregated performance measured by the Area Under Curve…

计算机视觉与模式识别 · 计算机科学 2025-07-25 Arthur Pignet , John Klein , Genevieve Robin , Antoine Olivier

Position encoding recently has shown effective in the transformer architecture. It enables valuable supervision for dependency modeling between elements at different positions of the sequence. In this paper, we first investigate various…

计算与语言 · 计算机科学 2023-11-09 Jianlin Su , Yu Lu , Shengfeng Pan , Ahmed Murtadha , Bo Wen , Yunfeng Liu

Since the emergence of the ImageNet dataset, the pretraining and fine-tuning approach has become widely adopted in computer vision due to the ability of ImageNet-pretrained models to learn a wide variety of visual features. However, a…

计算机视觉与模式识别 · 计算机科学 2024-10-22 Pablo Meseguer , Rocío del Amor , Adrian Colomer , Valery Naranjo

Accurate and efficient registration of whole slide images (WSIs) is essential for high-resolution, nuclei-level analysis in multi-stained tissue slides. We propose a novel coarse-to-fine framework CORE for accurate nuclei-level registration…

Computer-aided pathology diagnosis based on the classification of Whole Slide Image (WSI) plays an important role in clinical practice, and it is often formulated as a weakly-supervised Multiple Instance Learning (MIL) problem. Existing…

计算机视觉与模式识别 · 计算机科学 2022-10-11 Linhao Qu , Xiaoyuan Luo , Manning Wang , Zhijian Song

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for…

计算机视觉与模式识别 · 计算机科学 2024-05-06 Diogo J. Araújo , M. Rita Verdelho , Alceu Bissoto , Jacinto C. Nascimento , Carlos Santiago , Catarina Barata

Oncologists often rely on a multitude of data, including whole-slide images (WSIs), to guide therapeutic decisions, aiming for the best patient outcome. However, predicting the prognosis of cancer patients can be a challenging task due to…

图像与视频处理 · 电气工程与系统科学 2025-04-01 M Rita Verdelho , Alexandre Bernardino , Catarina Barata

Representation learning of pathology whole-slide images (WSIs) has been has primarily relied on weak supervision with Multiple Instance Learning (MIL). However, the slide representations resulting from this approach are highly tailored to…

计算机视觉与模式识别 · 计算机科学 2024-05-21 Andrew H. Song , Richard J. Chen , Tong Ding , Drew F. K. Williamson , Guillaume Jaume , Faisal Mahmood