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The dynamics of cellular aggregates is driven by the interplay of mechanochemical processes and cellular activity. Although deterministic models may capture mechanical features, local chemical fluctuations trigger random cell responses,…

软凝聚态物质 · 物理学 2024-01-17 Ana Carpio , Elena Cebrian

Biofilms are spatially organized microorganism colonies embedded in a self-produced matrix, conferring to the microbial community resistance to environmental stresses. Motile bacteria have been observed swimming in the matrix of pathogenic…

定量方法 · 定量生物学 2022-05-24 Guillaume Ravel , Michel Bergmann , Alain Trubuil , Julien Deschamps , Romain Briandet , Simon Labarthe

In natural environments, solid surfaces present both opportunities and challenges for bacteria. On one hand, they serve as platforms for biofilm formation, crucial for bacterial colonization and resilience in harsh conditions. On the other…

生物物理 · 物理学 2025-07-01 Antai Tao , Guangzhe Liu , Rongjing Zhang , Junhua Yuan

To model the morphogenesis of rod-shaped bacterial micro-colony, several individual-based models have been proposed in the biophysical literature. When studying the shape of micro-colonies, most models present interaction forces such as…

细胞行为 · 定量生物学 2020-08-12 Marie Doumic , Sophie Hecht , Diane Peurichard

Segregation of populations is a key question in evolution theory. One important aspect is the relation between spatial organization and the population's composition. Here we study a specific example -- sectors in expanding bacterial…

凝聚态物理 · 物理学 2009-10-31 Ido Golding , Inon Cohen , Eshel Ben-Jacob

Biofilms are communities of bacteria adhered to surfaces. Recently, biofilms of rod-shaped bacteria were observed at single-cell resolution and shown to develop from a disordered, two-dimensional layer of founder cells into a…

Densely packed, motile bacteria can adopt collective states not seen in conventional, passive materials. These states remain in many ways mysterious, and their physical characterization can aid our understanding of natural bacterial…

The effect of mechanical interactions between cells in the spreading of bacterial populations was investigated in one-dimensional space. A continuum-mechanics approach, comprising cell migration, proliferation, and exclusion processes, was…

生物物理 · 物理学 2015-12-15 Waipot Ngamsaad , Suthep Suantai

Despite the importance that fluid flow plays in transporting and organizing populations, few laboratory systems exist to systematically investigate the impact of advection on their spatial evolutionary dynamics. To address this problem, we…

软凝聚态物质 · 物理学 2019-07-03 Severine Atis , Bryan T. Weinstein , Andrew W. Murray , David R. Nelson

Immotile microbes inhabit nearly every environment on Earth, from soils and sediments to food matrices -- yet how they disperse through these physically confining environments is poorly understood. Here, we show that immotile microbial…

Growing living cultures of Escherichia coli bacteria were investigated using real-time in situ rheology and rheo-imaging measurements. In the early stages of growth (lag phase), and when subjected to a constant stationary shear, the…

生物物理 · 物理学 2016-12-21 R. Portela , P. Patrício , P. L. Almeida , R. G. Sobral , J. M. Franco , C. R. Leal

Biofilms are complex, self-organized consortia of microorganisms that produce a functional, protective matrix of biomolecules. Physically, the structure of a biofilm can be described as an entangled polymer network which grows and changes…

生物物理 · 物理学 2016-11-08 Marco G. Mazza

The spatial organization of bacteria in dense biofilms is key to their collective behaviour, and understanding it will be important for medical and technological applications. Here we study the morphology of a compact biofilm that undergoes…

生物物理 · 物理学 2019-03-05 Xin Wang , Howard A. Stone , Ramin Golestanian

From biofilm and colony formation in bacteria to wound healing and embryonic development in multicellular organisms, groups of living cells must often move collectively. While considerable study has probed the biophysical mechanisms of how…

生物物理 · 物理学 2022-06-08 Benedikt Sabass , Howard A. Stone , Joshua W. Shaevitz

Bacterial motility, and in particular repulsion or attraction towards specific chemicals, has been a subject of investigation for over 100 years, resulting in detailed understanding of bacterial chemotaxis and the corresponding sensory…

生物物理 · 物理学 2022-06-08 Jerko Rosko , Vincent Martinez , Wilson Poon , Teuta Pilizota

We present a two-species population model in a well-mixed environment where the dynamics involves, in addition to birth and death, changes due to environmental factors and inter-species interactions. The novel dynamical components are…

生物物理 · 物理学 2020-09-17 J. J. Dong , J. D. Russo , K. Sampson

Molecular communication promises to enable communication between nanomachines with a view to increasing their functionalities and open up new possible applications. Due to some of the biological properties, bacteria have been proposed as a…

新兴技术 · 计算机科学 2016-11-18 Monowar Hasan , Ekram Hossain , Sasitharan Balasubramaniam , Yevgeni Koucheryavy

We investigate the emergence of global alignment in colonies of dividing rod-shaped cells under confinement. Using molecular dynamics simulations and continuous modeling, we demonstrate that geometrical anisotropies in the confining…

软凝聚态物质 · 物理学 2021-01-26 Zhihong You , Daniel J. G. Pearce , Luca Giomi

Flagellar-driven locomotion plays a critical role in bacterial attachment and colonization of surfaces, contributing to the risks of contamination and infection. Tremendous attempts to uncover the underlying principles governing bacterial…

软凝聚态物质 · 物理学 2025-02-19 Xin-Xin Xu , Yangguang Tian , Yuhe Pu , Bingchen Che , Hao Luo , Yanan Liu , Yan-Jun Liu , Guangyin Jing

Bacteria often form surface-bound communities, embedded in a self-produced extracellular matrix, called biofilms. Quantitative studies of their growth have typically focused on unconfined expansion above solid or semi-solid surfaces,…

软凝聚态物质 · 物理学 2022-05-11 George T. Fortune , Nuno M. Oliveira , Raymond E. Goldstein