相关论文: The low-LET radiation contribution to the tumor do…
Particle physics simulations are the cornerstone of nuclear engineering applications. Among them radiotherapy (RT) is crucial for society, with 50% of cancer patients receiving radiation treatments. For the most precise targeting of tumors,…
Targeted alpha-particle therapy (TAT) employs alpha-emitting radionuclides conjugated to tumor-targeting molecules to deliver localized radiation to cancer cells, showing great promise in treating metastatic cancers. Among these…
Irradiations at Ultra High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radio-therapy with reduced harm to normal tissues. This…
Fermi-LAT observations of the Galactic Center (GC) have revealed a spherically- symmetric excess of GeV gamma rays extending to at least 10 deg from the dynamical center of the Galaxy. A critical uncertainty in extracting the intensity,…
We propose a mathematical model for estimating biological damage caused by low-dose irradiation. We understand that the Linear Non Threshold (LNT) hypothesis is realized only in the case of no recovery effects. In order to treat the…
This study aims to assess the composition of scattered particles generated in proton therapy for tumours situated proximal to titanium dental implants. The investigation involves decomposing the mixed field and recording Linear Energy…
Purpose: Historically, spot scanning proton therapy (SSPT) treatment planning utilizes dose volume constraints and linear-energy-transfer (LET) volume constraints separately to balance tumor control and organs-at-risk (OARs) protection. We…
Observations by the Large Area Telescope (LAT) on the \textit{Fermi} mission of diffuse $\gamma$-rays in a mid-latitude region in the third quadrant (Galactic longitude $l$ from $200\arcdeg$ to $260\arcdeg$ and latitude $| b |$ from…
As depth increases, linear energy transfer (LET) rises toward the distal edge of the Bragg peak, boosting the radiobiological effectiveness (RBE). To manage the biological variation and limit normal-tissue damage, LET-modifying objective…
In 1992 the Far-Ultraviolet Space Telescope (FAUST) provided measurements of the ultraviolet (140-180nm) diffuse sky background at high, medium, and low Galactic latitudes. A significant fraction of the detected radiation was found to be of…
In this paper, a reaction-diffusion system modeling injection of a chemotherapeutic drug on the surface of a living tissue during a treatment for cancer patients is studied. The system describes the interaction of the chemotherapeutic drug…
While spatial dose conformity delivered to a target volume has been pushed to its practical limits with advanced treatment planning and delivery, investigations in novel temporal dose delivery are unfolding new mechanisms. Recent advances…
A work recently published experimentally demonstrates an increase in the radiobiological efficacy of clinical proton beams when a tumour is treated in the presence of a concentration of 11B. The paper, for the first time, demonstrates the…
It has been shown recently that changing the fluidic properties of a drug can improve its efficacy in ablating solid tumors. We develop a modeling framework for tumor ablation, and present the simplest possible model for drug diffusion in a…
Targeted Alpha Therapy potentially offers a more specific action in killing tumor cells and less damage to neighbouring normal cells compared to $\beta$-emitters. $^{225}$Ac along with three other $\alpha$-emitting daughter nuclei…
Metastasis is the process by which cells from a primary tumor disperse and form new tumors at distant anatomical locations. The treatment and prevention of metastatic cancer remains an extremely challenging problem. This work introduces a…
Waves scattered by a weakly inhomogeneous random medium contain a predominant single scattering contribution as well as a multiple scattering contribution which is usually neglected, especially for imaging purposes. A method based on random…
We propose LD(Low Dose) model, the extension of LDM model which was proposed in the previous paper [Y. Manabe et al.: J. Phys. Soc. Jpn. 81 (2012) 104004] to estimate biological damage caused by irradiation. LD model takes account of all…
Narrow bandwidth, high energy photon sources can be generated by Thomson scattering of laser light from energetic electrons, and detailed control of the interaction is needed to produce high quality sources. We present analytic calculations…
Radiotherapy is a commonly used treatment for cancer and is usually given in varying doses. At low radiation doses relatively few cells die as a direct response to radiation but secondary radiation effects such as DNA mutation or bystander…