相关论文: Single shot diagnosis of ion channel dysfunction f…
Voltage-dependent ion channels determine the electric properties of axonal cell membranes. They not only allow the passage of ions through the cell membrane but also contribute to an additional charging of the cell membrane resulting in the…
Travelling waves of neural firing activity are observed in brain tissue as a part of various sensory, motor and cognitive processes. They represent an object of major interest in the study of excitable networks, with analysis conducted in…
Neurons are subject to various kinds of noise. In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal processing properties of the neuron. In this…
Neuronal cells present periodic trains of localized voltage spikes involving a large amount of different ionic channels. A relevant question is whether this is a cooperative effect or it could also be an intrinsic property of individual…
We have proposed an analytical approach for exact solution of multi-channel scattering problems, in presence of Dirac Delta function couplings. Our solution is quite general and is valid for any set of potentials, if the Green's functions…
Ion channels are membrane proteins responsible for an enormous range of biological functions. Ion selectivity and permeation are based on simple laws of physics and chemistry. Ion channels are therefore ideal candidates for physical…
We suggest to discriminate single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular…
We present a convolution-based data assimilation method tailored to neuronal electrophysiology, addressing the limitations of traditional value-based synchronization approaches. While conventional methods rely on nudging terms and pointwise…
Sleep apnea, a prevalent sleep disorder, involves repeated episodes of breathing interruptions during sleep, leading to various health complications, including cognitive impairments, high blood pressure, heart disease, stroke, and even…
Although interference alignment (IA) can theoretically achieve the optimal degrees of freedom (DoFs) in the $K$-user Gaussian interference channel, its direct application comes at the prohibitive cost of precoding over exponentially-many…
We report the detection of single ion impacts through monitoring of changes in the source-drain currents of field effect transistors (FET) at room temperature. Implant apertures are formed in the interlayer dielectrics and gate electrodes…
Over the past two decades, magnetic resonance spectroscopy with two-shot difference editing has been widely employed to characterize altered levels of GABA, the primary inhibitory neurotransmitter in the brain, in various neuropsychiatric…
Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of…
Synchronization in neural networks is strongly tied to the implementation of cognitive processes, but abnormal neuronal synchronization has been linked to a number of brain disorders such as epilepsy and schizophrenia. Here we examine the…
Using a stochastic generalization of the Hodgkin–Huxley model, we consider the influence of intrinsic channel noise on the synchronization between the spiking activity of the excitable membrane and an externally applied periodic…
We present experimental demonstrations of accurate and unambiguous single-shot discrimination between three quantum channels using a single trapped $^{40}\text{Ca}^{+}$ ion. The three channels cannot be distinguished unambiguously using…
Fluidic iontronics offer a unique capability for emulating the chemical processes found in neurons. We extract multiple distinct chemically regulated synaptic features from an experimentally accessible conical microfluidic channel carrying…
In this work the stochastic generalization of single Hodgkin-Huxley neuron is further extended to unidirectionally coupled neurons. Our main focus is to elucidate the role of channel noise in the kinetics and energetics of spiking of action…
Single-channel electroencephalogram (EEG) is a cost-effective, comfortable, and non-invasive method for monitoring brain activity, widely adopted by researchers, consumers, and clinicians. The increasing number and proportion of articles on…
Ion transport in biological and synthetic nanochannels is characterized by phenomena such as ion current fluctuations and rectification. Recently, it has been demonstrated that nanofabricated synthetic pores can mimic transport properties…