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A prompt public health response to a new epidemic relies on the ability to monitor and predict its evolution in real time as data accumulate. The 2009 A/H1N1 outbreak in the UK revealed pandemic data as noisy, contaminated, potentially…

Seasonal influenza epidemics cause consistent, considerable, widespread loss annually in terms of economic burden, morbidity, and mortality. With access to accurate and reliable forecasts of a current or upcoming influenza epidemic's…

种群与进化 · 定量生物学 2016-02-17 Logan C. Brooks , David C. Farrow , Sangwon Hyun , Ryan J. Tibshirani , Roni Rosenfeld

Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and…

种群与进化 · 定量生物学 2016-04-27 Richard A. Neher , Trevor Bedford , Rodney S. Daniels , Colin A. Russell , Boris I. Shraiman

Background: Early forecasts of dengue are an important tool for disease mitigation. Neural networks are powerful predictive models that have made contributions to many areas of public health. In this study, we reviewed the application of…

机器学习 · 计算机科学 2025-12-19 Luiza Lober , Francisco A. Rodrigues , Kirstin Roster

Influenza A is responsible for 290,000 to 650,000 respiratory deaths a year, though this estimate is an improvement from years past due to improvements in sanitation, healthcare practices, and vaccination programs. In this study, we perform…

机器学习 · 计算机科学 2025-07-29 Edmund F. Agyemang , Hansapani Rodrigo , Vincent Agbenyeavu

In this paper, we present a new approach to time series forecasting. Time series data are prevalent in many scientific and engineering disciplines. Time series forecasting is a crucial task in modeling time series data, and is an important…

机器学习 · 计算机科学 2020-01-24 Neo Wu , Bradley Green , Xue Ben , Shawn O'Banion

We propose an approach based on a combination of physical, chemical, and mathematical methods to identify and characterize virulent influenza A viruses (IAVs) through the analysis of the hemagglutinin protein. These methods include the…

定量方法 · 定量生物学 2024-11-08 Meitner Cadena , Alejandro Yerovi

Influenza remains a significant burden on health systems. Effective responses rely on the timely understanding of the magnitude and the evolution of an outbreak. For monitoring purposes, data on severe cases of influenza in England are…

Rapid identification of newly emerging or circulating viruses is an important first step toward managing the public health response to potential outbreaks. A portable virus capture device coupled with label-free Raman Spectroscopy holds the…

The evolution of the hemagglutinin amino acids sequences of Influenza A virus is studied by a method based on an informational metrics, originally introduced by Rohlin for partitions in abstract probability spaces. This metrics does not…

种群与进化 · 定量生物学 2015-06-03 Raffaella Burioni , Riccardo Scalco , Mario Casartelli

This study incorporates mathematical analysis, focusing on developing theories and conducting numerical simulations of Influenza virus transmission using real-world data. The terms in the equations introduce parameters which are determined…

综合数学 · 数学 2024-12-03 Md Kamrujjaman , Kazi Mehedi Mohammad

Early prediction of the prevalence of influenza reduces its impact. Various studies have been conducted to predict the number of influenza-infected people. However, these studies are not highly accurate especially in the distant future such…

机器学习 · 计算机科学 2019-07-08 Kenjiro Kondo , Akihiko Ishikawa , Masashi Kimura

Influenza epidemics result in a public health and economic burden around the globe. Traditional surveillance techniques, which rely on doctor visits, provide data with a delay of 1-2 weeks. A means of obtaining real-time data and…

种群与进化 · 定量生物学 2019-04-11 Wendy K. Caldwell , Geoffrey Fairchild , Sara Y. Del Valle

We introduce EINNs, a framework crafted for epidemic forecasting that builds upon the theoretical grounds provided by mechanistic models as well as the data-driven expressibility afforded by AI models, and their capabilities to ingest…

机器学习 · 计算机科学 2023-01-12 Alexander Rodríguez , Jiaming Cui , Naren Ramakrishnan , Bijaya Adhikari , B. Aditya Prakash

A combination of traditional image processing methods with advanced neural networks concretes a predictive and preventive healthcare paradigm. This study offers rapid, accurate, and non-invasive diagnostic solutions that can significantly…

Understanding how genetic changes allow emerging virus strains to escape the protection afforded by vaccination is vital for the maintenance of effective vaccines. In the current work, we use structural and phylogenetic differences between…

应用统计 · 统计学 2019-05-14 Vinny Davies , William T. Harvey , Richard Reeve , Dirk Husmeier

High order structures (cavities and cliques) of the gene network of influenza A virus reveal tight associations among viruses during evolution and are key signals that indicate viral cross-species infection and cause pandemics. As…

基因组学 · 定量生物学 2022-11-08 Junjie Li , Jietong Zhao , Yanqing Su , Jiahao Shen , Yaohua Liu , Xinyue Fan , Zheng Kou

Forecasting the hospitalizations caused by the Influenza virus is vital for public health planning so that hospitals can be better prepared for an influx of patients. Many forecasting methods have been used in real-time during the Influenza…

机器学习 · 计算机科学 2022-06-22 Majd Al Aawar , Ajitesh Srivastava

We found that the real time reverse transcription-polymerase chain reaction (RT-PCR) detection of viral RNA from sputum or nasopharyngeal swab has a relatively low positive rate in the early stage to determine COVID-19 (named by the World…

Epidemics of influenza are major public health concerns. Since influenza prediction always relies on the weekly clinical or laboratory surveillance data, typically the weekly Influenza-like illness (ILI) rate series, accurate…

机器学习 · 计算机科学 2021-10-28 Siyue Yang , Yukun Bao