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In biological microscopy, light scattering represents the main limitation to image at depth. Recently, a set of wavefront shaping techniques has been developed in order to manipulate coherent light in strongly disordered materials. The…

光学 · 物理学 2021-01-07 Antoine Boniface , Jonathan Dong , Sylvain Gigan

Two-photon (2P) microscopy is a powerful technique for deep-tissue fluorescence imaging; however, tissue scattering limits its effectiveness for depth imaging using conventional approaches. Despite typical strategies having been put forward…

光学 · 物理学 2025-05-21 Lei Zhu , Bernhard Rauer , Hilton B. De Aguiar , Sylvain Gigan

When light propagates through opaque material, the spatial information it holds becomes scrambled, but not necessarily lost. Two classes of techniques have emerged to recover this information: methods relying on optical memory effects, and…

光学 · 物理学 2021-08-10 Shuhui Li , Simon A. R. Horsley , Tomas Tyc , Tomas Cizmar , David B. Phillips

Optical wavefront-shaping has emerged as a powerful tool to manipulate light in strongly scattering media. It enables diffraction-limited focusing and imaging at depths where conventional microscopy techniques fail. However, while most…

光学 · 物理学 2014-03-04 T. Chaigne , O. Katz , A. C. Boccara , M. Fink , E. Bossy , S. Gigan

There are several methods to focus light behind a scattering medium, but very few use fluorescence light as feedback or can be used without access to the distal side of the scatterer. Among all the wave-front shaping techniques, retrieving…

光学 · 物理学 2020-03-18 Evolene Premillieu , Rafael Piestun

Wavefront-shaping is a promising approach for imaging fluorescent targets deep inside scattering tissue despite strong aberrations. It enables focusing an incoming illumination into a single spot inside tissue, as well as correcting the…

光学 · 物理学 2024-01-23 Dror Aizik , Anat Levin

Ultra-thin multimode optical fiber imaging promises next-generation medical endoscopes reaching high image resolution for deep tissues. However, current technology suffers from severe optical distortion, as the fiber's calibration is…

光学 · 物理学 2023-10-04 Yijie Zheng , George S. D. Gordon

Despite the tremendous progresses in wavefront control through or inside complex scattering media, several limitations prevent reaching practical feasibility for nonlinear imaging in biological tissues. While the optimization of nonlinear…

光学 · 物理学 2016-12-06 Hilton B. de Aguiar , Sylvain Gigan , Sophie Brasselet

Optical imaging through scattering media is a fundamental challenge in many applications. Recently, substantial breakthroughs such as imaging through biological tissues and looking around corners have been obtained by the use of…

光学 · 物理学 2020-07-09 Tomer Yeminy , Ori Katz

The scattering of multispectral incoherent light is a common and unfavorable signal scrambling in natural scenes. However, the blurred light spot due to scattering still holds lots of information remaining to be explored. Former methods…

图像与视频处理 · 电气工程与系统科学 2022-07-29 Yitong Li , Zhengbo Zhu , Ze Li , Donglin Ma

Several matrix approaches were developed to control light propagation through multiple scattering media under illumination of ultrashort pulses of light. These matrices can be recorded either with spectral or temporal resolution. Thanks to…

光学 · 物理学 2018-06-08 Mickael Mounaix , Duc Minh Ta , Sylvain Gigan

Diffraction-limited imaging through complex scattering media is a long sought after goal with important applications in biomedical research. In recent years, high resolution wavefront-shaping has emerged as a powerful approach to generate a…

光学 · 物理学 2014-10-17 Ori Katz , Eran Small , Yefeng Guan , Yaron Silberberg

Optical-resolution fluorescence imaging through and within complex samples presents a significant challenge due to random light scattering, with substantial implications across multiple fields. While significant advancements in coherent…

光学 · 物理学 2023-12-27 Gil Weinberg , Elad Sunray , Ori Katz

Deep, high-resolution imaging is essential for unraveling biological complexity and advancing medical diagnostics, yet scattering fundamentally limits optical methods. Among the most promising approaches, photoacoustic imaging achieves…

Imaging with undetected photons relies upon nonlinear interferometry to extract the spatial image from an infrared probe beam and reveal it in the interference pattern of an easier-to-detect visible beam. Typically, the transmission and…

We present an optical wavefront shaping approach that allows tracking and localization of signal hidden inside or behind a scattering medium. The method combines traditional feedback based wavefront shaping together with a switch function,…

Transmission matrix (TM) allows light control through complex media such as multimode fibers (MMFs), gaining great attention in areas like biophotonics over the past decade. The measurement of a complex-valued TM is highly desired as it…

Wavefront shaping makes it possible to form a focus through opaque scattering materials. In some cases, this focus may be scanned over a small distance using the optical memory effect. However, in many cases of interest, the optical memory…

光学 · 物理学 2020-01-08 Bahareh Mastiani , Tzu-Lun Ohn , Ivo M. Vellekoop

Accessing the point-spread function (PSF) of a complex optical system is important for a variety of imaging applications. However, placing an invasive point source is often impractical, and estimating it blindly with multiple frames is slow…

光学 · 物理学 2020-09-23 Tengfei Wu , Jonathan Dong , Sylvain Gigan

Optical approaches to fluorescent, spectroscopic, and morphological imaging have made exceptional advances in the last decade. Super-resolution imaging and wide-field multiphoton imaging are now underpinning major advances across the…

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