相关论文: CLCLSA: Cross-omics Linked embedding with Contrast…

Unsupervised learning of disease subtypes from multi-omics data presents a significant opportunity for advancing personalized medicine. We introduce OmicsCL, a modular contrastive learning framework that jointly embeds heterogeneous omics…

Background and Objective: Given the high heterogeneity and clinical diversity of cancer, substantial variations exist in multi-omics data and clinical features across different cancer subtypes. Methods: We propose a model, named DEDUCE,…

Advancements in technologies related to working with omics data require novel computation methods to fully leverage information and help develop a better understanding of human diseases. This paper studies the effects of introducing graph…

Recent advances in high-throughput sequencing technologies have enabled the extraction of multiple features that depict patient samples at diverse and complementary molecular levels. The generation of such data has led to new challenges in…

Advances in high-throughput technologies have originated an ever-increasing availability of omics datasets. The integration of multiple heterogeneous data sources is currently an issue for biology and bioinformatics. Multiple kernel…

Contrastive Learning (CL) performances as a rising approach to address the challenge of sparse and noisy recommendation data. Although having achieved promising results, most existing CL methods only perform either hand-crafted data or…

Most multi-view clustering methods are limited by shallow models without sound nonlinear information perception capability, or fail to effectively exploit complementary information hidden in different views. To tackle these issues, we…

State-of-the-art pre-trained image models predominantly adopt a two-stage approach: initial unsupervised pre-training on large-scale datasets followed by task-specific fine-tuning using Cross-Entropy loss~(CE). However, it has been…

High annotation costs are a substantial bottleneck in applying modern deep learning architectures to clinically relevant medical use cases, substantiating the need for novel algorithms to learn from unlabeled data. In this work, we propose…

Subspace clustering aims to group data points that lie in a union of low-dimensional subspaces and finds wide application in computer vision, hyperspectral imaging, and recommendation systems. However, most existing methods assume fully…

We have gained access to vast amounts of multi-omics data thanks to Next Generation Sequencing. However, it is challenging to analyse this data due to its high dimensionality and much of it not being annotated. Lack of annotated data is a…

Motivation: Network-based analyses of omics data are widely used, and while many of these methods have been adapted to single-cell scenarios, they often remain memory- and space-intensive. As a result, they are better suited to batch data…

The integration of different imaging modalities, such as structural, diffusion tensor, and functional magnetic resonance imaging, with deep learning models has yielded promising outcomes in discerning phenotypic characteristics and…

Learning effective visual representations without human supervision is a long-standing problem in computer vision. Recent advances in self-supervised learning algorithms have utilized contrastive learning, with methods such as SimCLR, which…

High content imaging assays can capture rich phenotypic response data for large sets of compound treatments, aiding in the characterization and discovery of novel drugs. However, extracting representative features from high content images…

Multi-view learning can cover all features of data samples more comprehensively, so multi-view learning has attracted widespread attention. Traditional subspace clustering methods, such as sparse subspace clustering (SSC) and low-ranking…

Integration of multi-omics data provides opportunities for revealing biological mechanisms related to certain phenotypes. We propose a novel method of multi-omics integration called supervised deep generalized canonical correlation analysis…

Multi-modal semantic understanding requires integrating information from different modalities to extract users' real intention behind words. Most previous work applies a dual-encoder structure to separately encode image and text, but fails…

Multiview clustering (MVC) segregates data samples into meaningful clusters by synthesizing information across multiple views. Moreover, deep learning-based methods have demonstrated their strong feature learning capabilities in MVC…

Many applications require linking individuals, firms, or locations across datasets. Most widely used methods, especially in social science, do not employ deep learning, with record linkage commonly approached using string matching…