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$\bf{Purpose}$: To describe the 3D structural changes in both connective and neural tissues of the optic nerve head (ONH) that occur concurrently at different stages of glaucoma using traditional and AI-driven approaches. $\bf{Methods}$: We…

Machine learning is gaining significant attention as a diagnostic tool in medical imaging, particularly in the analysis of retinal fundus images. However, this approach is not yet clinically applicable, as it still depends on human…

人机交互 · 计算机科学 2025-10-03 Mattea Reid , Zuhairah Zainal , Khaing Zin Than , Danielle Chan , Jonathan Chan

Computer vision leveraging deep learning has achieved significant success in the last decade. Despite the promising performance of the existing deep models in the recent literature, the extent of models' reliability remains unknown.…

计算机视觉与模式识别 · 计算机科学 2020-04-13 Seyed Omid Sajedi , Xiao Liang

Effectively medication recommendation with complex multimorbidity conditions is a critical task in healthcare. Most existing works predicted medications based on longitudinal records, which assumed the information transmitted patterns of…

机器学习 · 计算机科学 2023-09-13 Sicen Liu , Xiaolong Wang , JIngcheng Du , Yongshuai Hou , Xianbing Zhao , Hui Xu , Hui Wang , Yang Xiang , Buzhou Tang

Spatial connectivity is an important consideration when modelling infectious disease data across a geographical region. Connectivity can arise for many reasons, including shared characteristics between regions, and human or vector movement.…

统计方法学 · 统计学 2022-06-06 Sophie A Lee , Theodoros Economou , Rachel Lowe

Accurate estimates of subnational health and demographic indicators are critical for informing health policy decisions. Many countries collect relevant data using complex household surveys, but when data are limited, direct survey weighted…

统计方法学 · 统计学 2022-09-07 Peter A. Gao , Jon Wakefield

Glaucoma is the number one cause of irreversible blindness globally. A major challenge for accurate glaucoma detection and progression forecasting is the bottleneck of limited labeled patients with the state-of-the-art (SOTA) 3D retinal…

计算机视觉与模式识别 · 计算机科学 2023-08-28 Yan Luo , Min Shi , Yu Tian , Tobias Elze , Mengyu Wang

Background/Aims: Standard Automated Perimetry (SAP) is the gold standard to monitor visual field (VF) loss in glaucoma management, but is prone to intra-subject variability. We developed and validated a deep learning (DL) regression model…

图像与视频处理 · 电气工程与系统科学 2021-06-08 Ruben Hemelings , Bart Elen , João Barbosa Breda , Erwin Bellon , Matthew B Blaschko , Patrick De Boever , Ingeborg Stalmans

Glaucoma is one of the most severe eye diseases, characterized by rapid progression and leading to irreversible blindness. It is often the case that diagnostics is carried out when one's sight has already significantly degraded due to the…

图像与视频处理 · 电气工程与系统科学 2022-08-02 Ahmed Al Mahrooqi , Dmitrii Medvedev , Rand Muhtaseb , Mohammad Yaqub

Observing retinal fundus images by an ophthalmologist is a major diagnosis approach for glaucoma. However, it is still difficult to distinguish the features of the lesion solely through manual observations, especially, in glaucoma early…

图像与视频处理 · 电气工程与系统科学 2020-01-08 Peng Liu , Ruogu Fang

A popular method for indexing numerical representations is to compute an individual estimate of a response time effect, such as the SNARC effect or the numerical distance effect. Classically, this is done by estimating individual linear…

应用统计 · 统计学 2017-10-24 Thomas J. Faulkenberry

We develop a Bayesian bivariate spatial model for multivariate regression analysis applicable to studies examining the influence of genetic variation on brain structure. Our model is motivated by an imaging genetics study of the Alzheimer's…

统计方法学 · 统计学 2020-05-26 Yin Song , Shufei Ge , Jiguo Cao , Liangliang Wang , Farouk S. Nathoo

Large longitudinal studies provide lots of valuable information, especially in medical applications. A problem which must be taken care of in order to utilize their full potential is that of correlation between intra-subject measurements…

统计方法学 · 统计学 2022-02-14 Martin Hanik , Hans-Christian Hege , Christoph von Tycowicz

Existing studies for automated melanoma diagnosis are based on single-time point images of lesions. However, melanocytic lesions de facto are progressively evolving and, moreover, benign lesions can progress into malignant melanoma.…

计算机视觉与模式识别 · 计算机科学 2020-06-22 Zhen Yu , Jennifer Nguyen , Xiaojun Chang , John Kelly , Catriona Mclean , Lei Zhang , Victoria Mar , Zongyuan Ge

For civil structures, structural damage due to severe loading events such as earthquakes, or due to long-term environmental degradation, usually occurs in localized areas of a structure. A new sparse Bayesian probabilistic framework for…

应用统计 · 统计学 2015-07-02 Yong Huang , James L. Beck

Spatial confounding is how is called the confounding between fixed and spatial random effects. It has been widely studied and it gained attention in the past years in the spatial statistics literature, as it may generate unexpected results…

The hippocampus is one of the most studied neuroanatomical structures due to its involvement in attention, learning, and memory as well as its atrophy in ageing, neurological, and psychiatric diseases. Hippocampal shape changes, however,…

计算机视觉与模式识别 · 计算机科学 2023-06-13 Kersten Diers , Hannah Baumeister , Frank Jessen , Emrah Düzel , David Berron , Martin Reuter

Illness-death models are a class of stochastic models inside the multi-state framework. In those models, individuals are allowed to move over time between different states related to illness and death. They are of special interest when…

应用统计 · 统计学 2022-10-14 Fran Llopis-Cardona , Carmen Armero , Gabriel Sanfélix-Gimeno

The crossed random effects model is widely used, finding applications in various fields such as longitudinal studies, e-commerce, and recommender systems, among others. However, these models encounter scalability challenges, as the…

统计方法学 · 统计学 2025-10-21 Disha Ghandwani , Swarnadip Ghosh , Trevor Hastie , Art B. Owen

We propose a method to learn a distribution of shape trajectories from longitudinal data, i.e. the collection of individual objects repeatedly observed at multiple time-points. The method allows to compute an average spatiotemporal…

计算机视觉与模式识别 · 计算机科学 2018-06-14 Alexandre Bône , Olivier Colliot , Stanley Durrleman