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Centrifugation is a widespread laboratory technique used to separate mixtures into fractions characterized by a specific size, weight or density. We demonstrate that centrifugation can be also used to separate swimming cells having…

软凝聚态物质 · 物理学 2014-11-07 Claudio Maggi , Alessia Lepore , Jacopo Solari , Alessandro Rizzo , Roberto Di Leonardo

Constricted blood vessels in the circulatory system can severely impact the spatiotemporal organization of red blood cells (RBCs) causing various physiological complications. In lab-on-a-chip applications, constrictions are commonly used…

Margination, a fundamental process in which leukocytes migrate from the flowing blood to the vessel wall, is well-documented in physiology. However, it is still an open question on how the differences in cell size and stiffness of white and…

软凝聚态物质 · 物理学 2024-09-05 Revaz D. Chachanidze , Othmane Aouane , Jens Harting , Christian Wagner , Marc Leonetti

An erythrocytes sedimentation rate (ESR) measures how fast a blood sample sediments along a test tube in one hour in a clinical laboratory. Since elevated level of ESR is associated with inflammatory diseases, ESR is one of the routine…

生物物理 · 物理学 2019-07-30 Mesfin Asfaw Taye

Understanding how red blood cell (RBC) suspensions navigate porous materials is critical for for both fundamental physiology, such as maternal-fetal exchange in the placenta, and transformative biomedical applications, including rapid,…

软凝聚态物质 · 物理学 2025-09-03 Sampad Laha , Ananta Kumar Nayak , Alexander Farutin , Suman Chakraborty , Chaouqi Misbah

Red blood cells (RBCs) are an essential component of blood. A method to include the particulate nature of blood is introduced here with the goal of studying circulation in large-scale realistic vessels. The method uses a combination of the…

医学物理 · 物理学 2011-07-26 Simone Melchionna

Understanding the physics of blood is challenging due to its nature as a suspension of soft particles and the fact that typical problems involve different scales. This is valid also for numerical investigations. In fact, many computational…

软凝聚态物质 · 物理学 2011-09-16 Florian Janoschek , Federico Toschi , Jens Harting

The dynamics of single red blood cells (RBCs) determine microvascular blood flow by adapting their shape to the flow conditions in the narrow vessels. In this study, we explore the dynamics and shape transitions of RBCs on the cellular…

The more we learn about the cytoplasm of cells, the more we realise that the cytoplasm is not uniform but instead is highly inhomogeneous. In any inhomogeneous solution, there are concentration gradients, and particles move either up or…

亚细胞过程 · 定量生物学 2019-04-03 Richard P. Sear

One of the main characteristics of blood coagulation is the speed of clot growth. This parameter strongly depends on the speed of propagation of the thrombin concentration in blood plasma. In the current work we consider mathematical model…

动力系统 · 数学 2016-04-27 Tatiana Galochkina , Anass Bouchnita , Polina Kurbatova , Vitaly Volpert

A mixed suspension of red blood cells (RBCs) and microparticles flows through a cylindrical channel with a constriction mimicking a stenosed blood vessel. Our three-dimensional Lattice-Boltzmann simulations show that the RBCs are depleted…

流体动力学 · 物理学 2017-02-01 Christian Bächer , Lukas Schrack , Stephan Gekle

We present a scheme to extract information about plumes, a prominent coherent structure in turbulent thermal convection, from simultaneous local velocity and temperature measurements. Using this scheme, we study the temperature dependence…

混沌动力学 · 物理学 2009-11-10 Emily S. C. Ching , H. Guo , Xiao-Dong Shang , P. Tong , Ke-Qing Xia

Platelet-enriched plasma and red blood cells (RBC) are needed in the treatment of blood-related diseases, including anaemia and blood cancer. These essential components must be separated from blood in well-designed experimental setups. If…

流体动力学 · 物理学 2026-03-16 Rishi Kumar , Indranil Saha Dalal , K. Muralidhar

Flowing blood displays a phenomenon called margination, in which leukocytes and platelets are preferentially found near blood vessel walls, while erythrocytes are depleted from these regions. Here margination is investigated using direct…

软凝聚态物质 · 物理学 2012-09-05 Amit Kumar , Michael D. Graham

Numerical simulations of turbulent stratified convection are used to study models with approximately the same convective flux, but different radiative fluxes. As the radiative flux is decreased, for constant convective flux: the entropy…

天体物理学 · 物理学 2007-05-23 A. Brandenburg , K. L. Chan , A. Nordlund , R. F. Stein

The velocity relaxation of an impulsively forced spherical particle in a fluid confined by two parallel plane walls is studied using a direct numerical simulation approach. During the relaxation process, the momentum of the particle is…

流体动力学 · 物理学 2015-06-15 Rei Tatsumi , Ryoichi Yamamoto

The multi-cellular hydrodynamic interactions play a critical role in the phenomenology of blood flow in the microcirculation. A fast algorithm has been developed to simulate large numbers of cells modeled as elastic thin membranes. For red…

流体动力学 · 物理学 2008-10-14 Amir H. G. Isfahani , Hong Zhao , Jonathan B. Freund

The purpose of this work is to use active particles to study the effect of facilitation on supercooled liquids. To this end we investigate the behavior of a model supercooled liquid doped with intermittently active and intermittently slowed…

软凝聚态物质 · 物理学 2023-08-11 Victor Teboul

The impact of cell segregation and margination in blood disorders on microcirculatory hemodynamics within bifurcated vessels are physiologically significant, yet poorly understood. This study presents a comprehensive computational…

生物物理 · 物理学 2025-01-09 Xiaopo Cheng , Christina Caruso , Wilbur A. Lam , Michael D. Graham

Rayleigh-B\'enard convection, i.e. the flow of a fluid between two parallel plates that is driven by a temperature gradient, is an idealised setup to study thermal convection. Of special interest are the statistics of the turbulent…

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