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Designing structurally stable RNA sequences with specific motifs and other desirable properties is an important challenge in bioinformatics. The potential design space increases exponentially with the length of the RNA to be engineered,…

定量方法 · 定量生物学 2025-07-23 Narges Zarnaghinaghsh , Byung-Jun Yoon

Variational autoencoders (VAE) are a powerful and widely-used class of models to learn complex data distributions in an unsupervised fashion. One important limitation of VAEs is the prior assumption that latent sample representations are…

机器学习 · 计算机科学 2018-11-27 Francesco Paolo Casale , Adrian V Dalca , Luca Saglietti , Jennifer Listgarten , Nicolo Fusi

As machine learning based systems become more integrated into daily life, they unlock new opportunities but face the challenge of adapting to dynamic data environments. Various forms of data shift-gradual, abrupt, or cyclic-threaten model…

机器学习 · 计算机科学 2025-06-04 Bonpagna Kann , Sandra Castellanos-Paez , Romain Rombourg , Philippe Lalanda

Predicting cellular responses to various perturbations is a critical focus in drug discovery and personalized therapeutics, with deep learning models playing a significant role in this endeavor. Single-cell datasets contain technical…

机器学习 · 计算机科学 2024-09-11 Seungheun Baek , Soyon Park , Yan Ting Chok , Junhyun Lee , Jueon Park , Mogan Gim , Jaewoo Kang

Graph Auto-Encoders (GAEs) are powerful tools for graph representation learning. In this paper, we develop a novel Hierarchical Cluster-based GAE (HC-GAE), that can learn effective structural characteristics for graph data analysis. To this…

机器学习 · 计算机科学 2024-05-24 Zhuo Xu , Lu Bai , Lixin Cui , Ming Li , Yue Wang , Edwin R. Hancock

Variational Autoencoders (VAEs) are a popular generative model, but one in which conditional inference can be challenging. If the decomposition into query and evidence variables is fixed, conditional VAEs provide an attractive solution. To…

机器学习 · 统计学 2018-10-05 Ga Wu , Justin Domke , Scott Sanner

Learning a robust video Variational Autoencoder (VAE) is essential for reducing video redundancy and facilitating efficient video generation. Directly applying image VAEs to individual frames in isolation can result in temporal…

计算机视觉与模式识别 · 计算机科学 2024-12-24 Yazhou Xing , Yang Fei , Yingqing He , Jingye Chen , Jiaxin Xie , Xiaowei Chi , Qifeng Chen

Density estimation, compression and data generation are crucial tasks in artificial intelligence. Variational Auto-Encoders (VAEs) constitute a single framework to achieve these goals. Here, we present a novel class of generative models,…

机器学习 · 统计学 2021-07-07 Ioannis Gatopoulos , Jakub M. Tomczak

Variational Auto-Encoders (VAEs) are capable of learning latent representations for high dimensional data. However, due to the i.i.d. assumption, VAEs only optimize the singleton variational distributions and fail to account for the…

机器学习 · 计算机科学 2020-04-20 Da Tang , Dawen Liang , Tony Jebara , Nicholas Ruozzi

Karyotyping is of importance for detecting chromosomal aberrations in human disease. However, chromosomes easily appear curved in microscopic images, which prevents cytogeneticists from analyzing chromosome types. To address this issue, we…

计算机视觉与模式识别 · 计算机科学 2023-06-27 Jingxiong Li , Sunyi Zheng , Zhongyi Shui , Shichuan Zhang , Linyi Yang , Yuxuan Sun , Yunlong Zhang , Honglin Li , Yuanxin Ye , Peter M. A. van Ooijen , Kang Li , Lin Yang

Variational autoencoders (VAE) are powerful generative models that learn the latent representations of input data as random variables. Recent studies show that VAE can flexibly learn the complex temporal dynamics of time series and achieve…

机器学习 · 计算机科学 2023-11-14 Borui Cai , Shuiqiao Yang , Longxiang Gao , Yong Xiang

We propose Tree Variational Autoencoder (TreeVAE), a new generative hierarchical clustering model that learns a flexible tree-based posterior distribution over latent variables. TreeVAE hierarchically divides samples according to their…

机器学习 · 计算机科学 2023-11-20 Laura Manduchi , Moritz Vandenhirtz , Alain Ryser , Julia Vogt

We propose a multi-layer variational autoencoder method, we call HR-VQVAE, that learns hierarchical discrete representations of the data. By utilizing a novel objective function, each layer in HR-VQVAE learns a discrete representation of…

计算机视觉与模式识别 · 计算机科学 2022-08-10 Mohammad Adiban , Kalin Stefanov , Sabato Marco Siniscalchi , Giampiero Salvi

Deep generative models provide flexible frameworks for modeling complex, structured data such as images, videos, 3D objects, and texts. However, when applied to sequences of human skeletons, standard variational autoencoders (VAEs) often…

计算机视觉与模式识别 · 计算机科学 2026-05-18 Arafat Rahman , Shashwat Kumar , Laura E. Barnes , Anuj Srivastava

The problem of fair classification can be mollified if we develop a method to remove the embedded sensitive information from the classification features. This line of separating the sensitive information is developed through the causal…

机器学习 · 计算机科学 2020-12-10 Hyemi Kim , Seungjae Shin , JoonHo Jang , Kyungwoo Song , Weonyoung Joo , Wanmo Kang , Il-Chul Moon

For planning of power systems and for the calibration of operational tools, it is essential to analyse system performance in a large range of representative scenarios. When the available historical data is limited, generative models are a…

系统与控制 · 电气工程与系统科学 2022-12-16 Chenguang Wang , Ensieh Sharifnia , Zhi Gao , Simon H. Tindemans , Peter Palensky

Variational Autoencoders (VAEs) are powerful in data representation inference, but it cannot learn relations between features with its vanilla form and common variations. The ability to capture relations within data can provide the much…

机器学习 · 计算机科学 2020-07-23 Chen Wang , Chengyuan Deng , Vladimir Ivanov

Multimodal Variational Autoencoders have emerged as a popular tool to extract effective representations from rich multimodal data. However, such models rely on fusion strategies in latent space that destroy the joint statistical structure…

机器学习 · 计算机科学 2026-03-03 Federico Caretti , Guido Sanguinetti

Causal disentanglement from soft interventions is identifiable under the assumptions of linear interventional faithfulness and availability of both observational and interventional data. Previous research has looked into this problem from…

机器学习 · 计算机科学 2025-09-03 Jifan Zhang , Michelle M. Li , Elena Zheleva

Variational autoencoders (VAEs) have recently been used for unsupervised disentanglement learning of complex density distributions. Numerous variants exist to encourage disentanglement in latent space while improving reconstruction.…

机器学习 · 统计学 2022-06-10 Kenneth Ezukwoke , Anis Hoayek , Mireille Batton-Hubert , Xavier Boucher