相关论文: Tomographic imaging of microvasculature with a pur…
Visualizing the anatomical vessel networks plays a vital role in physiological or pathological investigations. However, identifying the fine structures of the smallest capillary vessels via conventional imaging ways remains a big challenge.…
Articular cartilage is a musculoskeletal soft tissue renowned for its unique mechanical properties. Understanding both its hierarchical structure and the interplay between its constituents could shed light on the mechanical competence of…
Articular cartilage showcases distinctive mechanical behaviour, attributable to its biphasic composition and hierarchical organization. Proteoglycans, essential constituents of the extracellular matrix, contribute to tissue swelling,…
We propose an imaging system and methodology for mapping soft-tissue samples in three dimensions, with micron-scale and isotropic spatial resolution, with low-concentrations as well as in the absence of heavy metal staining. We used hard…
In the recent years, we witness a great interest in imaging, in a wide sense, using contrast agents. One of the reasons is that many imaging modalities, as the ones related to medical sciences, suffer from several shortcomings. The most…
X-ray microtomography is a versatile tool allowing the measurement of the 3D structure of optically thick samples. As a non-destructive technique, it is readily adapted to 4D imaging, where a sample can be monitored over time, and…
X-ray micro tomography is a non-destructive, three-dimensional inspection technique applied across a vast range of fields and disciplines, ranging from research to industrial, encompassing engineering, biology and medical research.…
Microfluidic devices are increasingly used in synchrotron-based experiments to deliver and probe liquid samples, offering advantages such as minimal sample consumption and reduced radiation damage. Despite their growing use, few devices…
An optical microscope enables image-based findings and diagnosis on microscopic targets, which is indispensable in many scientific, industrial and medical settings. Majority of microscope users are accustomed to standard benchtop…
Contrast microbubbles (contrast agents) were initially developed to increase the contrast of the image in ultrasound imaging. These microbubbles consist of a gas core encapsulated by a layer of protein or lipid to stabilize them against…
Microvascular imaging has advanced significantly with ultrafast data acquisition and improved clutter filtering, enhancing the sensitivity of power Doppler imaging to small vessels. However, the image quality remains limited by spatial…
Contrast-enhanced imaging is central to oncologic diagnosis, but contrast agents can be contraindicated for many of the patients who need them most. Synthesizing contrast scans from non-contrast inputs is the natural response. Two obstacles…
X-ray phase contrast imaging (XPCI) provides higher sensitivity to contrast between low absorbing objects that can be invisible to conventional attenuation-based X-ray imaging. XPCI's main application has been so far focused on medical…
Electron and x-ray microscopes allow one to image the entire, unlabeled structure of hydrated materials at a resolution well beyond what visible light microscopes can achieve. However, both approaches involve ionizing radiation, so that…
Correlative microscopy is a powerful technique that combines the advantages of multiple imaging modalities to achieve a comprehensive understanding of investigated samples. For example, fluorescence microscopy provides unique functional…
We used a microfluidic platform to address the problems of obtaining diffraction quality crystals and crystal handling during transfer to the X-ray diffractometer. We optimize crystallization conditions of a pharmaceutical protein and…
Cryopreservation via vitrification requires loading cryoprotective cocktails. Insufficient loading may lead to freezing, precluding successful recovery; overloading is toxic. Yet, existing in situ measurements of cryoprotectant permeation…
Background and objective: CTA is a gold standard of preoperative diagnosis of abdominal aorta and typically used for geometric-only characteristic extraction. We assume that a model describing the dynamic behavior of the contrast agent in…
Ultrasound localization microscopy offers new radiation-free diagnostic tools for vascular imaging deep within the tissue. Sequential localization of echoes returned from inert microbubbles with low-concentration within the bloodstream…
Fabrication of X-ray gratings has surged in the last two decades thanks to their vast employment in X-ray Phase Contrast Imaging, an imaging technique able to boost X-ray sensitivity to detect otherwise invisible details. These high aspect…