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Alzheimer's disease (AD), a degenerative brain condition, can benefit from early prediction to slow its progression. As the disease progresses, patients typically undergo brain atrophy. Current prediction methods for Alzheimers disease…

计算机视觉与模式识别 · 计算机科学 2025-11-27 Xin Honga , Jie Lin , Minghui Wang

Correlation matrices are fundamental summaries of functional brain networks, yet standard analyses often treat entries independently, ignoring the curved geometry of correlation space. Existing geometric methods frequently lack closed-form…

机器学习 · 计算机科学 2026-05-22 Mario Severino , Manuela Moretto , Robert A. McCutcheon , Mattia Veronese

Hyperbolic deep learning has become a growing research direction in computer vision due to the unique properties afforded by the alternate embedding space. The negative curvature and exponentially growing distance metric provide a natural…

计算机视觉与模式识别 · 计算机科学 2026-02-10 Ahmad Bdeir , Johannes Burchert , Lars Schmidt-Thieme , Niels Landwehr

Progressive diseases worsen over time and are characterised by monotonic change in features that track disease progression. Here we connect ideas from two formerly separate methodologies -- event-based and hidden Markov modelling -- to…

机器学习 · 计算机科学 2021-06-07 Peter A. Wijeratne , Daniel C. Alexander

Statistical shape modeling is an essential tool for the quantitative analysis of anatomical populations. Point distribution models (PDMs) represent the anatomical surface via a dense set of correspondences, an intuitive and easy-to-use…

图像与视频处理 · 电气工程与系统科学 2022-01-11 Wenzheng Tao , Riddhish Bhalodia , Shireen Elhabian

Modern approaches to pose and body shape estimation have recently achieved strong performance even under challenging real-world conditions. Even from a single image of a clothed person, a realistic looking body shape can be inferred that…

计算机视觉与模式识别 · 计算机科学 2020-10-23 Hosnieh Sattar , Katharina Krombholz , Gerard Pons-Moll , Mario Fritz

Modern machine learning increasingly leverages the insight that high-dimensional data often lie near low-dimensional, non-linear manifolds, an idea known as the manifold hypothesis. By explicitly modeling the geometric structure of data…

机器学习 · 计算机科学 2026-03-02 Willem Diepeveen , Deanna Needell

Statistical models of 3D human shape and pose learned from scan databases have developed into valuable tools to solve a variety of vision and graphics problems. Unfortunately, most publicly available models are of limited expressiveness as…

计算机视觉与模式识别 · 计算机科学 2017-03-07 Leonid Pishchulin , Stefanie Wuhrer , Thomas Helten , Christian Theobalt , Bernt Schiele

The brain-age gap is one of the most investigated risk markers for brain changes across disorders. While the field is progressing towards large-scale models, recently incorporating uncertainty estimates, no model to date provides the…

Statistical shape modeling (SSM) is a powerful computational framework for quantifying and analyzing the geometric variability of anatomical structures, facilitating advancements in medical research, diagnostics, and treatment planning.…

计算机视觉与模式识别 · 计算机科学 2024-05-24 Krithika Iyer , Jadie Adams , Shireen Y. Elhabian

Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising…

A novel framework is proposed for handling the complex task of modelling and analysis of longitudinal, multivariate, heterogeneous clinical data. This method uses temporal abstraction to convert the data into a more appropriate form for…

机器学习 · 计算机科学 2025-05-09 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

We study possible relations between the structure of the connectome, white matter connecting different regions of brain, and Alzheimer disease. Regression models in covariates including age, gender and disease status for the extent of white…

统计方法学 · 统计学 2021-04-22 Arkaprava Roy , Subhashis Ghosal , Jeffrey Prescott , Kingshuk Roy Choudhury

The analysis of manifold-valued data requires efficient tools from Riemannian geometry to cope with the computational complexity at stake. This complexity arises from the always-increasing dimension of the data, and the absence of…

计算机视觉与模式识别 · 计算机科学 2017-11-27 Maxime Louis , Alexandre Bône , Benjamin Charlier , Stanley Durrleman

Survival prediction models can potentially be used to guide treatment of glioblastoma patients. However, currently available MR imaging biomarkers holding prognostic information are often challenging to interpret, have difficulties…

图像与视频处理 · 电气工程与系统科学 2021-09-28 Sveinn Pálsson , Stefano Cerri , Hans Skovgaard Poulsen , Thomas Urup , Ian Law , Koen Van Leemput

Diffusion models are recent state-of-the-art methods for image generation and likelihood estimation. In this work, we generalize continuous-time diffusion models to arbitrary Riemannian manifolds and derive a variational framework for…

机器学习 · 计算机科学 2022-08-18 Chin-Wei Huang , Milad Aghajohari , Avishek Joey Bose , Prakash Panangaden , Aaron Courville

Predicting an individual's aging trajectory is a central challenge in preventative medicine and bioinformatics. While machine learning models can predict chronological age from biomarkers, they often fail to capture the dynamic,…

机器学习 · 计算机科学 2025-08-14 Nazira Dunbayeva , Yulong Li , Yutong Xie , Imran Razzak

Brain aging is a widely studied longitudinal process throughout which the brain undergoes considerable morphological changes and various machine learning approaches have been proposed to analyze it. Within this context, brain age prediction…

计算机视觉与模式识别 · 计算机科学 2020-11-30 Matthias Wilms , Jordan J. Bannister , Pauline Mouches , M. Ethan MacDonald , Deepthi Rajashekar , Sönke Langner , Nils D. Forkert

This paper presents a mathematical framework for analyzing machine learning models through the geometry of their induced partitions. By representing partitions as Riemannian simplicial complexes, we capture not only adjacency relationships…

机器学习 · 计算机科学 2025-08-05 Pawel Gajer , Jacques Ravel

Alzheimer's disease progression prediction is critical for patients with early Mild Cognitive Impairment (MCI) to enable timely intervention and improve their quality of life. While existing progression prediction techniques demonstrate…

计算机视觉与模式识别 · 计算机科学 2025-11-18 Zhongying Deng , Shujun Wang , Angelica I Aviles-Rivero , Zoe Kourtzi , Carola-Bibiane Schönlieb