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Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

The field of hypothesis generation promises to reduce costs in neuroscience by narrowing the range of interventional studies needed to study various phenomena. Existing machine learning methods can generate scientific hypotheses from…

机器学习 · 计算机科学 2025-07-04 Zachary C. Brown , David Carlson

Causal effect estimation under observational studies is challenging due to the lack of ground truth data and treatment assignment bias. Though various methods exist in literature for addressing this problem, most of them ignore…

人工智能 · 计算机科学 2024-12-11 Abhinav Thorat , Ravi Kolla , Niranjan Pedanekar

Recent approaches in causal inference have proposed estimating average causal effects that are local to some subpopulation, often for reasons of efficiency. These inferential targets are sometimes data-adaptive, in that they are dependent…

统计理论 · 数学 2016-02-08 Peter M. Aronow

Biomarker discovery from high-throughput transcriptomic data is crucial for advancing precision medicine. However, existing methods often neglect gene-gene regulatory relationships and lack stability across datasets, leading to conflation…

定量方法 · 定量生物学 2025-11-18 Chaowang Lan , Jingxin Wu , Yulong Yuan , Chuxun Liu , Huangyi Kang , Caihua Liu

Recent work on recommender systems has considered external knowledge graphs as valuable sources of information, not only to produce better recommendations but also to provide explanations of why the recommended items were chosen. Pure…

信息检索 · 计算机科学 2020-07-28 Yikun Xian , Zuohui Fu , Qiaoying Huang , S. Muthukrishnan , Yongfeng Zhang

Within the field of causal inference, we consider the problem of estimating heterogeneous treatment effects from data. We propose and validate a novel approach for learning feature representations to aid the estimation of the conditional…

机器学习 · 统计学 2022-06-23 Michael C. Burkhart , Gabriel Ruiz

Consider the problem of estimating the causal effect of some attribute of a text document; for example: what effect does writing a polite vs. rude email have on response time? To estimate a causal effect from observational data, we need to…

机器学习 · 统计学 2023-02-09 Lin Gui , Victor Veitch

ML is playing an increasingly crucial role in estimating causal effects of treatments on outcomes from observational data. Many ML methods (`causal estimators') have been proposed for this task. All of these methods, as with any ML…

机器学习 · 计算机科学 2025-10-06 Damian Machlanski , Spyridon Samothrakis , Paul Clarke

Causal effect estimation from observational data is a crucial but challenging task. Currently, only a limited number of data-driven causal effect estimation methods are available. These methods either provide only a bound estimation of the…

统计方法学 · 统计学 2020-11-10 Debo Cheng , Jiuyong Li , Lin Liu , Kui Yu , Thuc Duy Lee , Jixue Liu

In some causal inference scenarios, the treatment variable is measured inaccurately, for instance in epidemiology or econometrics. Failure to correct for the effect of this measurement error can lead to biased causal effect estimates.…

机器学习 · 计算机科学 2024-09-13 Antti Pöllänen , Pekka Marttinen

Causal discovery from observational data is challenging, especially with large datasets and complex relationships. Traditional methods often struggle with scalability and capturing global structural information. To overcome these…

机器学习 · 计算机科学 2025-07-29 Rezaur Rashid , Gabriel Terejanu

This paper develops new methods for causal inference in observational studies on a single large network of interconnected units, addressing two key challenges: long-range dependence among units and the presence of general interference. We…

统计方法学 · 统计学 2025-11-24 Jizhou Liu , Dake Zhang , Eric J. Tchetgen Tchetgen

Estimating causal effects from high-dimensional, structured exposures is a fundamental challenge in modern applications ranging from neuroscience and finance to environmental science. While the literature has addressed high-dimensional…

统计方法学 · 统计学 2026-04-29 Samhita Pal , Dhrubajyoti Ghosh

In recent years, there has been a growing interest in using machine learning techniques for the estimation of treatment effects. Most of the best-performing methods rely on representation learning strategies that encourage shared behavior…

机器学习 · 计算机科学 2024-04-19 Roger Pros , Jordi Vitrià

Nonlinear causal discovery from observational data imposes strict identifiability assumptions on the formulation of structural equations utilized in the data generating process. The evaluation of structure learning methods under assumption…

机器学习 · 统计学 2024-12-17 Georg Velev , Stefan Lessmann

Experiments are the gold standard for causal inference. In many applications, experimental units can often be recruited or chosen sequentially, and the adaptive execution of such experiments may offer greatly improved inference of causal…

统计方法学 · 统计学 2023-06-14 Difan Song , Simon Mak , C. F. Jeff Wu

Recent work has made important contributions in the development of causally-interpretable meta-analysis. These methods transport treatment effects estimated in a collection of randomized trials to a target population of interest. Ideally,…

统计方法学 · 统计学 2023-02-08 Justin M. Clark , Kollin W. Rott , James S. Hodges , Jared D. Huling

Causal modeling provides us with powerful counterfactual reasoning and interventional mechanism to generate predictions and reason under various what-if scenarios. However, causal discovery using observation data remains a nontrivial task…

机器学习 · 计算机科学 2023-01-06 Jawad Chowdhury , Rezaur Rashid , Gabriel Terejanu

Estimating average causal effect (ACE) is useful whenever we want to know the effect of an intervention on a given outcome. In the absence of a randomized experiment, many methods such as stratification and inverse propensity weighting have…

机器学习 · 计算机科学 2019-07-11 Rathin Desai , Amit Sharma