相关论文: MLT-LE: predicting drug-target binding affinity wi…

Vulnerability to adversarial attacks is a well-known weakness of Deep Neural networks. While most of the studies focus on single-task neural networks with computer vision datasets, very little research has considered complex multi-task…

Machine learning shows great potential in virtual screening for drug discovery. Current efforts on accelerating docking-based virtual screening do not consider using existing data of other previously developed targets. To make use of the…

Accurate prediction of protein-ligand interactions is essential for computer-aided drug discovery. However, existing methods often fail to capture solvent-dependent conformational changes and lack the ability to jointly learn multiple…

Multi-task learning (MTL) seeks to improve the generalized performance of learning specific tasks, exploiting useful information incorporated in related tasks. As a promising area, this paper studies an MTL-based control approach…

Prediction of protein-ligand (PL) binding affinity remains the key to drug discovery. Popular approaches in recent years involve graph neural networks (GNNs), which are used to learn the topology and geometry of PL complexes. However, GNNs…

Multitask deep learning has been applied to patient outcome prediction from text, taking clinical notes as input and training deep neural networks with a joint loss function of multiple tasks. However, the joint training scheme of multitask…

Accurate prediction of Drug-Target Affinity (DTA) is of vital importance in early-stage drug discovery, facilitating the identification of drugs that can effectively interact with specific targets and regulate their activities. While wet…

While the promises of Multi-Task Learning (MTL) are attractive, characterizing the conditions of its success is still an open problem in Deep Learning. Some tasks may benefit from being learned together while others may be detrimental to…

The accurate screening of candidate drug ligands against target proteins through computational approaches is of prime interest to drug development efforts. Such virtual screening depends in part on methods to predict the binding affinity…

Multi-task learning (MTL) in deep neural networks for NLP has recently received increasing interest due to some compelling benefits, including its potential to efficiently regularize models and to reduce the need for labeled data. While it…

Multi-task learning (MTL) aims at learning related tasks in a unified model to achieve mutual improvement among tasks considering their shared knowledge. It is an important topic in recommendation due to the demand for multi-task prediction…

Despite the recent progress in deep learning, most approaches still go for a silo-like solution, focusing on learning each task in isolation: training a separate neural network for each individual task. Many real-world problems, however,…

Traditionally, multitask learning (MTL) assumes that all the tasks are related. This can lead to negative transfer when tasks are indeed incoherent. Recently, a number of approaches have been proposed that alleviate this problem by…

Multimedia applications often require concurrent solutions to multiple tasks. These tasks hold clues to each-others solutions, however as these relations can be complex this remains a rarely utilized property. When task relations are…

With the rise of neural networks in various domains, multi-task learning (MTL) gained significant relevance. A key challenge in MTL is balancing individual task losses during neural network training to improve performance and efficiency…

Multi-task learning (MTL) has been widely used in recommender systems, wherein predicting each type of user feedback on items (e.g, click, purchase) are treated as individual tasks and jointly trained with a unified model. Our key…

Multi-Task Learning (MTL) aims to learn multiple tasks simultaneously while exploiting their mutual relationships. By using shared resources to simultaneously calculate multiple outputs, this learning paradigm has the potential to have…

Hand-crafted features extracted from dynamic contrast-enhanced magnetic resonance images (DCE-MRIs) have shown strong predictive abilities in characterization of breast lesions. However, heterogeneity across medical image datasets hinders…

Multi-Task Learning (MTL) is a learning paradigm in machine learning and its aim is to leverage useful information contained in multiple related tasks to help improve the generalization performance of all the tasks. In this paper, we give a…

Predicting drug-target binding affinity (DTA) is essential for identifying potential therapeutic candidates in drug discovery. However, most existing models rely heavily on static protein structures, often overlooking the dynamic nature of…