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相关论文: Mediation Analysis with Multiple Exposures and Mul…

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Causal mediation analysis examines causal pathways linking exposures to disease. The estimation of interventional effects, which are mediation estimands that overcome certain identifiability problems of natural effects, has been advanced…

统计方法学 · 统计学 2025-04-23 Tong Chen , Stijn Vansteelandt , David Burgner , Toby Mansell , Margarita Moreno-Betancur

Mediation analysis is concerned with the decomposition of the total effect of an exposure on an outcome into the indirect effect through a given mediator, and the remaining direct effect. This is ideally done using longitudinal measurements…

统计理论 · 数学 2019-12-04 Murthy N Mittinty , Stijn Vansteelandt

Mediation analysis has become a widely used method for identifying the pathways through which an independent variable influences a dependent variable via intermediate mediators. However, limited research addresses the case where mediators…

统计方法学 · 统计学 2025-06-10 Rui Ren , Haoyi Yang , Qian Xiao , Lingzhou Xue , Yuan Huang

Mediation analysis aims to separate the indirect effect through mediators from the direct effect of the exposure on the outcome. It is challenging to perform mediation analysis with neuroimaging data which involves high dimensionality,…

统计方法学 · 统计学 2025-12-30 Yuliang Xu , Timothy D Johnson , Mary Heitzeg , Jian Kang

The goal of causal mediation analysis, often described within the potential outcomes framework, is to decompose the effect of an exposure on an outcome of interest along different causal pathways. Using the assumption of sequential…

统计方法学 · 统计学 2021-11-09 Lexi Rene , Antonio R. Linero , Elizabeth Slate

Causal mediation analysis is an important statistical tool to quantify effects transmitted by intermediate variables from a cause to an outcome. There is a gap in mediation analysis methods to handle mixture mediator data that are…

统计方法学 · 统计学 2025-07-22 Meilin Jiang , Seonjoo Lee , A. James O'Malley , Pengfei Li , Zhigang Li

This paper provides robust estimators and efficient inference of causal effects involving multiple interacting mediators. Most existing works either impose a linear model assumption among the mediators or are restricted to handle…

统计方法学 · 统计学 2024-01-12 Haoyu Wei , Hengrui Cai , Chengchun Shi , Rui Song

In this study, a longitudinal regression model for covariance matrix outcomes is introduced. The proposal considers a multilevel generalized linear model for regressing covariance matrices on (time-varying) predictors. This model…

统计方法学 · 统计学 2022-02-10 Yi Zhao , Brian S. Caffo , Xi Luo

An essential goal of program evaluation and scientific research is the investigation of causal mechanisms. Over the past several decades, causal mediation analysis has been used in medical and social sciences to decompose the treatment…

统计方法学 · 统计学 2016-01-15 K. C. G. Chan , K. Imai , S. C. P. Yam , Z. Zhang

Mediation analysis seeks to infer how much of the effect of an exposure on an outcome can be attributed to specific pathways via intermediate variables or mediators. This requires identification of so-called path-specific effects. These…

统计方法学 · 统计学 2019-06-06 Johan Steen , Stijn Vansteelandt

In this review paper, some applications of the mixed effect modeling in medial image processing and longitudinal analysis is studied. For this purpose, a general structure is extracted from some of the researches in the literature. This…

医学物理 · 物理学 2018-03-13 Fatemeh Nasiri , Oscar Acosta-Tamayo

Principal Component Analysis (PCA) is a fundamental tool for data visualization, denoising, and dimensionality reduction. It is widely popular in Statistics, Machine Learning, Computer Vision, and related fields. However, PCA is well-known…

机器学习 · 统计学 2023-07-21 Debolina Paul , Saptarshi Chakraborty , Swagatam Das

We propose new parametric frameworks of regression analysis with the conditional mode of a bounded response as the focal point of interest. Covariate effects estimation and prediction based on the maximum likelihood method under two new…

统计方法学 · 统计学 2020-06-22 Haiming Zhou , Xianzheng Huang

Mediation analysis in causal inference typically concentrates on one binary exposure, using deterministic interventions to split the average treatment effect into direct and indirect effects through a single mediator. Yet, real-world…

统计方法学 · 统计学 2023-07-07 David B. McCoy , Alan E. Hubbard , Mark van der Laan , Alejandro Schuler

Mediation analysis plays a crucial role in causal inference as it can investigate the pathways through which treatment influences outcome. Most existing mediation analysis assumes that mediation effects are static and homogeneous within…

统计方法学 · 统计学 2026-03-02 Yijiao Zhang , Yubai Yuan , Yuexia Zhang , Zhongyi Zhu , Annie Qu

Causal mediation analysis is increasingly abundant in biology, psychology, and epidemiology studies, etc. In particular, with the advent of the big data era, the issue of high-dimensional mediators is becoming more prevalent. In…

统计方法学 · 统计学 2023-07-10 Minghao Chen , Yingchun Zhou

Common psychiatric and brain disorders are highly heritable and affected by a number of genetic risk factors, yet the mechanism by which these genetic factors contribute to the disorders through alterations in brain structure and function…

统计方法学 · 统计学 2025-11-26 Neng Wang , Eric V. Slud , Tianzhou Ma

Principal component analysis (PCA) is a widely used method for data processing, such as for dimension reduction and visualization. Standard PCA is known to be sensitive to outliers, and thus, various robust PCA methods have been proposed.…

机器学习 · 统计学 2020-08-11 Keishi Sando , Hideitsu Hino

It becomes increasingly popular to perform mediation analysis for complex data from sophisticated experimental studies. In this paper, we present Granger Mediation Analysis (GMA), a new framework for causal mediation analysis of multiple…

统计方法学 · 统计学 2017-09-18 Yi Zhao , Xi Luo

Causal mediation analyses investigate the mechanisms through which causes exert their effects, and are therefore central to scientific progress. The literature on the non-parametric definition and identification of mediational effects in…

机器学习 · 统计学 2025-06-13 Richard Liu , Nicholas T. Williams , Kara E. Rudolph , Iván Díaz