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In this paper, we present a decision support framework for optimizing multiple aspects of vaccine distribution across a multitier cold chain network. We propose two multi-period optimization formulations within this framework: first to…

物理与社会 · 物理学 2022-01-12 Shanmukhi Sripada , Ayush Jain , Prasanna Ramamoorthy , Varun Ramamohan

This research investigates a multi-product, multi-echelon, and multi-period vaccine supply chain network model under uncertainty and quality inspection errors. The objective function seeks optimizing the total cost of the supply chain.…

最优化与控制 · 数学 2024-05-07 Bouchenine Abderrahmen , Almaraj Ismail

During various stages of the COVID-19 pandemic, countries implemented diverse vaccine management approaches, influenced by variations in infrastructure and socio-economic conditions. This article provides a comprehensive overview of…

最优化与控制 · 数学 2024-05-27 Shibshankar Dey , Ali Kaan Kurbanzade , Esma S. Gel , Joseph Mihaljevic , Sanjay Mehrotra

Vaccinating the global population against Covid-19 is one of the biggest supply chain management challenges humanity has ever faced. Rapid supply of Covid-19 vaccines is essential for successful global immunization, but its effectiveness…

密码学与安全 · 计算机科学 2022-09-22 Soroush Goodarzi , Vahid Kayvanfar , Alireza Haji , Alireza Shirzad

Millions of young people are not immunized in low- and middle-income (LMI) countries because of low vaccine availability resulting from inefficiencies in cold supply chains. We create supply chain network design and distribution models to…

应用统计 · 统计学 2020-06-11 Zahra Azadi , Sandra D. Eksioglu , H. Neil Geismar

Vaccines play a crucial role in the prevention and control of infectious diseases. However, the vaccine supply chain faces numerous challenges that hinder its efficiency. To address these challenges and enhance public health outcomes, many…

理论经济学 · 经济学 2025-10-07 Ran Gu , Enhui Ding , Shigui Ma

With the approval of vaccines for the coronavirus disease by many countries worldwide, most developed nations have begun, and developing nations are gearing up for the vaccination process. This has created an urgent need to provide a…

计算机与社会 · 计算机科学 2021-02-09 Mahzabeen Emu , Dhivya Chandrasekaran , Vijay Mago , Salimur Choudhury

This research is about COVID-19, which is a contagious virus that reached many countries, including Lebanon. Monitoring the outbreak, researchers have been involved in introducing COVID-19 targeting vaccines. Already facing financial and…

应用统计 · 统计学 2023-12-22 Sarkis Der Wartanian , Baydaa Al Ayoubi

The COVID19 pandemic has highlighted the lack of resilience in supply chains, as global networks fail from disruptions at single nodes and connections. Through an overview of the existing vaccine and pharmaceutical supply chain publications…

物理与社会 · 物理学 2020-12-01 Maureen S. Golan , Benjamin D. Trump , Jeffrey C. Cegan , Igor Linkov

Purpose: Only few companies were able to produce vaccine again COVID-19. Thus, one producer supplied it to many countries. The distribution was not effective. Some countries overstocked the vaccine while other countries were not able to buy…

物理与社会 · 物理学 2024-08-20 Béla Vizvári , Gergely Kovács

Timely and effective decision-making is critical during epidemics to reduce preventable infections and deaths. This demands integrated models that jointly capture disease dynamics, vaccine distribution, regional disparities, and behavioral…

社会与信息网络 · 计算机科学 2025-11-26 Kimiya Jozani , Nihal A. Sageer , Hode Eldardiry , Sait Tunc , Esra Buyuktahtakin Toy

The recent global outbreak of covid-19 is affecting many countries around the world. Due to the growing number of newly infected individuals and the health-care system bottlenecks, it will be useful to predict the upcoming number of…

机器学习 · 计算机科学 2021-03-18 Jafar Abdollahi , Amir Jalili Irani , Babak Nouri-Moghaddam

The COVID-19 pandemic exposed critical vulnerabilities in vaccine supply chains, highlighting the need for robust manufacturing for rapid pandemic response to support CEPI's 100 Days Mission. We develop a discrete-event simulation model to…

综合经济学 · 经济学 2026-02-10 Robin Kelchtermans , Valentijn Stienen , Guido Dietrich , Mauro Bernuzzi , Nico Vandaele

The COVID-19 vaccine development, manufacturing, transportation, and administration proved an extreme logistics operation of global magnitude. Global vaccination levels, however, remain a key concern in preventing the emergence of new…

综合经济学 · 经济学 2025-01-10 Sharika J. Hegde , Max T. M. Ng , Marcos Rios , Hani S. Mahmassani , Ying Chen , Karen Smilowitz

With the continuous rise of the COVID-19 cases worldwide, it is imperative to ensure that all those vulnerable countries lacking vaccine resources can receive sufficient support to contain the risks. COVAX is such an initiative operated by…

计算工程、金融与科学 · 计算机科学 2022-01-20 Navpreet Kaur , Jason Hughes , Juntao Chen

How to ensure accessibility to food and nutrition while food supply chains suffer from demand and supply uncertainties caused by disruptive forces such as the COVID-19 pandemic and natural disasters is an emerging and critical issue.…

综合经济学 · 经济学 2024-06-14 Mengfei Chen , Mohamed Kharbeche , Mohamed Haouari , Weihong "Grace" Guo

Since early 2020, the world has been dealing with a raging pandemic outbreak: COVID-19. A year later, vaccines have become accessible, but in limited quantities, so that governments needed to devise a strategy to decide which part of the…

种群与进化 · 定量生物学 2022-04-13 Sander Tonkens , Paul de Klaver , Mauro Salazar

As observed during the COVID-19 pandemic, high-income countries, such as the U.S., may exhibit vaccine nationalism during a pandemic: stockpiling doses of vaccine for their own citizens and being reluctant to distribute doses of the vaccine…

种群与进化 · 定量生物学 2024-08-21 Abraham Holleran , Susan E. Martonosi , Michael Veatch

The outbreak of COVID-19 led to a record-breaking race to develop a vaccine. However, the limited vaccine capacity creates another massive challenge: how to distribute vaccines to mitigate the near-end impact of the pandemic? In the United…

The focus of this research is to evaluate the use of drones for the delivery of pediatric vaccines in remote areas of low income and low and middle income countries. Delivering vaccines in these regions is challenging because of the…

最优化与控制 · 数学 2022-08-10 Maximilian Kolter , Sandra D. Eksioglu , Sarah Nurre Pinkley , Ruben A. Proano
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