相关论文: A smile is all you need: Predicting limiting activ…

Recent advances in large language models (LLMs) have demonstrated transformative potential across diverse fields. While LLMs have been applied to molecular simplified molecular input line entry system (SMILES) in computer-aided synthesis…

Automatic Speech Recognition (ASR) models demonstrate outstanding performance on high-resource languages but face significant challenges when applied to low-resource languages due to limited training data and insufficient cross-lingual…

SMILES is a linear representation of chemical structures which encodes the connection table, and the stereochemistry of a molecule as a line of text with a grammar structure denoting atoms, bonds, rings and chains, and this information can…

In the intersection of molecular science and deep learning, tasks like virtual screening have driven the need for a high-throughput molecular representation generator on large chemical databases. However, as SMILES strings are the most…

Speech Language Models (SLMs) have recently emerged as a unified paradigm for addressing a wide range of speech-related tasks, including text-to-speech (TTS), speech enhancement (SE), and automatic speech recognition (ASR). However, the…

Functional groups and moieties are chemical descriptors of biomolecules that can be used to interpret their properties and functions, leading to the understanding of chemical or biological mechanisms. These chemical building blocks, or…

SMILES, a crucial textual representation of molecular structures, has garnered significant attention as a foundation for pre-trained language models (LMs). However, most existing pre-trained SMILES LMs focus solely on the single-token level…

Task-adaptive pre-training (TAPT) and Self-training (ST) have emerged as the major semi-supervised approaches to improve natural language understanding (NLU) tasks with massive amount of unlabeled data. However, it's unclear whether they…

Speech representations learned from Self-supervised learning (SSL) models can benefit various speech processing tasks. However, utilizing SSL representations usually requires fine-tuning the pre-trained models or designing task-specific…

Predicting the inhibitory potency of small molecules against Tyrosyl-DNA Phosphodiesterase 1 (TDP1)-a key target in overcoming cancer chemoresistance-remains a critical challenge in early drug discovery. We present a deep learning framework…

While LLM-based TTS models exhibit zero-shot emotion and speaker cloning, their cloning fidelity and pronunciation clarity degrade on unseen domains. Fine-tuning is essential for adaptation, yet uniform approaches overlook specific…

Speech-to-singing voice conversion (STS) task always suffers from data scarcity, because it requires paired speech and singing data. Compounding this issue are the challenges of content-pitch alignment and the suboptimal quality of…

This thesis focuses on improving the pre-training of natural language models using unsupervised raw data to make them more efficient and aligned with downstream applications. In the first part, we introduce three alternative pre-training…

In this work, we introduce a novel approach for predicting thermodynamic properties of binary mixtures, which we call the similarity-based method (SBM). The method is based on quantifying the pairwise similarity of components, which we…

Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have…

Chemical databases store information in text representations, and the SMILES format is a universal standard used in many cheminformatics software. Encoded in each SMILES string is structural information that can be used to predict complex…

We study the ability of transformer-based language models (LMs) to understand social media language. Social media (SM) language is distinct from standard written language, yet existing benchmarks fall short of capturing LM performance in…

Molecular property prediction has gained significant attention due to its transformative potential in multiple scientific disciplines. Conventionally, a molecule graph can be represented either as a graph-structured data or a SMILES text.…

The lack of parallel data for many language pairs is an important challenge to statistical machine translation (SMT). One common solution is to pivot through a third language for which there exist parallel corpora with the source and target…

Protein structure tokenizers (PSTs) are workhorses in protein language modeling, function prediction, and evolutionary analysis. However, existing PSTs only capture local geometry of static structures, and miss the correlated motions and…