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Deep learning has been extensively researched in the analysis of pathology whole-slide images (WSIs). However, most existing methods are limited to providing prediction interpretability by locating the model's salient areas in a post-hoc…

机器学习 · 计算机科学 2026-02-04 Zekang Yang , Hong Liu , Xiangdong Wang

Multi-instance learning (MIL) deals with objects represented as bags of instances and can predict instance labels from bag-level supervision. However, significant performance gaps exist between instance-level MIL algorithms and supervised…

机器学习 · 计算机科学 2022-10-06 Weijia Zhang , Xuanhui Zhang , Han-Wen Deng , Min-Ling Zhang

We introduce PathBench-MIL, an open-source AutoML and benchmarking framework for multiple instance learning (MIL) in histopathology. The system automates end-to-end MIL pipeline construction, including preprocessing, feature extraction, and…

计算机视觉与模式识别 · 计算机科学 2025-12-22 Siemen Brussee , Pieter A. Valkema , Jurre A. J. Weijer , Thom Doeleman , Anne M. R. Schrader , Jesper Kers

In computational pathology, weak supervision has become the standard for deep learning due to the gigapixel scale of WSIs and the scarcity of pixel-level annotations, with Multiple Instance Learning (MIL) established as the principal…

计算机视觉与模式识别 · 计算机科学 2025-12-17 Andreas Lolos , Theofilos Christodoulou , Aris L. Moustakas , Stergios Christodoulidis , Maria Vakalopoulou

Digital pathology based on whole slide images (WSIs) plays a key role in cancer diagnosis and clinical practice. Due to the high resolution of the WSI and the unavailability of patch-level annotations, WSI classification is usually…

计算机视觉与模式识别 · 计算机科学 2023-05-02 Litao Yang , Deval Mehta , Sidong Liu , Dwarikanath Mahapatra , Antonio Di Ieva , Zongyuan Ge

Foundation models (FMs) have transformed computational pathology by providing powerful, general-purpose feature extractors. However, adapting and benchmarking individual FMs for specific diagnostic tasks is often time-consuming and…

计算机视觉与模式识别 · 计算机科学 2025-10-07 Peiran Quan , Zifan Gu , Zhuo Zhao , Qin Zhou , Donghan M. Yang , Ruichen Rong , Yang Xie , Guanghua Xiao

Multiple Instance Learning (MIL) has enabled weakly supervised analysis of whole-slide images (WSIs) in computational pathology. However, traditional MIL approaches often lose crucial contextual information, while transformer-based…

计算机视觉与模式识别 · 计算机科学 2025-12-30 Xitong Ling , Minxi Ouyang , Xiaoxiao Li , Jiawen Li , Ying Chen , Yuxuan Sun , Xinrui Chen , Tian Guan , Xiaoping Liu , Yonghong He

This paper introduces MAD-MIL, a Multi-head Attention-based Deep Multiple Instance Learning model, designed for weakly supervised Whole Slide Images (WSIs) classification in digital pathology. Inspired by the multi-head attention mechanism…

计算机视觉与模式识别 · 计算机科学 2024-04-09 Hassan Keshvarikhojasteh , Josien Pluim , Mitko Veta

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

定量方法 · 定量生物学 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Attention-based multiple instance learning (AMIL) algorithms have proven to be successful in utilizing gigapixel whole-slide images (WSIs) for a variety of different computational pathology tasks such as outcome prediction and cancer…

Breast cancer has the highest mortality among cancers in women. Computer-aided pathology to analyze microscopic histopathology images for diagnosis with an increasing number of breast cancer patients can bring the cost and delays of…

计算机视觉与模式识别 · 计算机科学 2020-03-03 Abhijeet Patil , Dipesh Tamboli , Swati Meena , Deepak Anand , Amit Sethi

Conventional Time Series Classification (TSC) methods are often black boxes that obscure inherent interpretation of their decision-making processes. In this work, we leverage Multiple Instance Learning (MIL) to overcome this issue, and…

机器学习 · 计算机科学 2024-03-19 Joseph Early , Gavin KC Cheung , Kurt Cutajar , Hanting Xie , Jas Kandola , Niall Twomey

The detection of induced pluripotent stem cell (iPSC) colonies often needs the precise extraction of the colony features. However, existing computerized systems relied on segmentation of contours by preprocessing for classifying the colony…

图像与视频处理 · 电气工程与系统科学 2022-03-10 Novanto Yudistira , Muthu Subash Kavitha , Jeny Rajan , Takio Kurita

Multiple instance learning (MIL) has shown significant promise in histopathology whole slide image (WSI) analysis for cancer diagnosis and prognosis. However, the inherent spatial heterogeneity of WSIs presents critical challenges, as…

计算机视觉与模式识别 · 计算机科学 2026-01-13 Junjian Li , Jin Liu , Hulin Kuang , Hailin Yue , Mengshen He , Jianxin Wang

Reliable identification of molecular biomarkers is essential for accurate patient stratification. While state-of-the-art machine learning approaches for sample classification continue to push boundaries in terms of performance, most of…

分子网络 · 定量生物学 2019-11-07 Matteo Manica , Joris Cadow , Roland Mathis , María Rodríguez Martínez

Multiple-instance Learning (MIL) is commonly used to undertake computational pathology (CPath) tasks, and the use of multi-scale patches allows diverse features across scales to be learned. Previous studies using multi-scale features in…

计算机视觉与模式识别 · 计算机科学 2026-02-03 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A Fallowfield , Hakan Bilen , Timothy J Kendall

Multiple instance learning (MIL) significantly reduced annotation costs via bag-level weak labels for large-scale images, such as histopathological whole slide images (WSIs). However, its adaptability to continual tasks with minimal…

计算机视觉与模式识别 · 计算机科学 2025-07-09 Byung Hyun Lee , Wongi Jeong , Woojae Han , Kyoungbun Lee , Se Young Chun

Multiple instance learning (MIL) is a form of weakly supervised learning where training instances are arranged in sets, called bags, and a label is provided for the entire bag. This formulation is gaining interest because it naturally fits…

计算机视觉与模式识别 · 计算机科学 2022-05-10 Marc-André Carbonneau , Veronika Cheplygina , Eric Granger , Ghyslain Gagnon

Classical multiple instance learning (MIL) methods are often based on the identical and independent distributed assumption between instances, hence neglecting the potentially rich contextual information beyond individual entities. On the…

计算机视觉与模式识别 · 计算机科学 2022-06-20 Daniel Reisenbüchler , Sophia J. Wagner , Melanie Boxberg , Tingying Peng

Multiple Instance Learning (MIL) represents the predominant framework in Whole Slide Image (WSI) classification, covering aspects such as sub-typing, diagnosis, and beyond. Current MIL models predominantly rely on instance-level features…

计算机视觉与模式识别 · 计算机科学 2024-07-26 Heng Fang , Sheng Huang , Wenhao Tang , Luwen Huangfu , Bo Liu